Cross_talk_ID	m6A_Regulator_ID	m6A_Target_ID	Epigenetic_Regulation_Type_all	Epigenetic_Regulator_ID	Regulated_Target_ID	Downstream Gene ID	m6A_Methylation_Regulation	Cross_talk_Relationship_1	Cross_talk_Relationship_2	Cross_talk_Relationship_3	Cross_talk_Relationship_4	Crosstalk_Mechanism	Cross_talk_Summary	Disease_ID	PMID	Drug_ID
M6ACROT00001	REG00007	M6ATAR00213	RNA modification / m5C	EPIREG00001	EPITAR00001	.	Up regulation	m5C	Direct	Enhancement	m6A	RNA modification directly impacts m6A modification through targeting the shared RNA	"NSUN2-mediated m5C and METTL3/METTL14-mediated m6A methylation synergistically enhance Cyclin-dependent kinase inhibitor 1 (CDKN1A) expression at the translational level, leading to elevated expression of p21 in oxidative stress-induced cellular senescence."	.	28247949	.
M6ACROT00002	REG00006	M6ATAR00213	RNA modification / m5C	EPIREG00001	EPITAR00001	.	Up regulation	m5C	Direct	Enhancement	m6A	RNA modification directly impacts m6A modification through targeting the shared RNA	"NSUN2-mediated m5C and METTL3/METTL14-mediated m6A methylation synergistically enhance Cyclin-dependent kinase inhibitor 1 (CDKN1A) expression at the translational level, leading to elevated expression of p21 in oxidative stress-induced cellular senescence."	.	28247949	.
M6ACROT00003	REG00007	M6ATAR00763	RNA modification / A-to-I	EPIREG00002	EPITAR00002	.	.	m6A	Direct	Inhibition	A-to-I	m6A modification directly impacts RNA modification through targeting the shared RNA	"Both the presence and extent of A-to-I sites in m6A-negative RNA transcripts suggest a negative correlation between m6A and A-to-I. Suppression of m6A-catalyzing enzymes results in global A-to-I RNA editing changes. Further depletion of m6A modification increases the association of m6A-depleted transcripts with adenosine deaminase acting on RNA (ADAR) enzymes, resulting in upregulated A-to-I editing on the same m6A-depleted transcripts. Inhibition of METTL3 enhances ADAR1-mediated A-to-I editing of Tyrosine-protein kinase EIF2AK2 (eIF2AK2/p68) by reducing its m6A modification."	.	29304330	M6ADRUG0218
M6ACROT00004	REG00007	M6ATAR01518	RNA modification / A-to-I	EPIREG00002	EPITAR00003	.	.	m6A	Direct	Inhibition	A-to-I	m6A modification directly impacts RNA modification through targeting the shared RNA	"Both the presence and extent of A-to-I sites in m6A-negative RNA transcripts suggest a negative correlation between m6A and A-to-I. Suppression of m6A-catalyzing enzymes results in global A-to-I RNA editing changes. Further depletion of m6A modification increases the association of m6A-depleted transcripts with adenosine deaminase acting on RNA (ADAR) enzymes, resulting in upregulated A-to-I editing on the same m6A-depleted transcripts. Inhibition of METTL3 enhances ADAR1-mediated A-to-I editing of LIM domain-containing protein ajuba (AJUBA) by reducing its m6A modification."	.	29304330	.
M6ACROT00005	REG00007	M6ATAR01519	RNA modification / A-to-I	EPIREG00002	EPITAR00004	.	.	m6A	Direct	Inhibition	A-to-I	m6A modification directly impacts RNA modification through targeting the shared RNA	"Both the presence and extent of A-to-I sites in m6A-negative RNA transcripts suggest a negative correlation between m6A and A-to-I. Suppression of m6A-catalyzing enzymes results in global A-to-I RNA editing changes. Further depletion of m6A modification increases the association of m6A-depleted transcripts with adenosine deaminase acting on RNA (ADAR) enzymes, resulting in upregulated A-to-I editing on the same m6A-depleted transcripts. Inhibition of METTL3 enhances ADAR1-mediated A-to-I editing of Small nuclear ribonucleoprotein Sm D3 (SNRPD3) by reducing its m6A modification."	.	29304330	.
M6ACROT00006	REG00007	M6ATAR01520	RNA modification / A-to-I	EPIREG00002	EPITAR00005	.	.	m6A	Direct	Inhibition	A-to-I	m6A modification directly impacts RNA modification through targeting the shared RNA	"Both the presence and extent of A-to-I sites in m6A-negative RNA transcripts suggest a negative correlation between m6A and A-to-I. Suppression of m6A-catalyzing enzymes results in global A-to-I RNA editing changes. Further depletion of m6A modification increases the association of m6A-depleted transcripts with adenosine deaminase acting on RNA (ADAR) enzymes, resulting in upregulated A-to-I editing on the same m6A-depleted transcripts. Inhibition of METTL3 enhances ADAR1-mediated A-to-I editing of DNA replication complex GINS protein SLD5 (GINS4) by reducing its m6A modification."	.	29304330	.
M6ACROT00007	REG00007	M6ATAR01521	RNA modification / A-to-I	EPIREG00002	EPITAR00006	.	.	m6A	Direct	Inhibition	A-to-I	m6A modification directly impacts RNA modification through targeting the shared RNA	"Both the presence and extent of A-to-I sites in m6A-negative RNA transcripts suggest a negative correlation between m6A and A-to-I. Suppression of m6A-catalyzing enzymes results in global A-to-I RNA editing changes. Further depletion of m6A modification increases the association of m6A-depleted transcripts with adenosine deaminase acting on RNA (ADAR) enzymes, resulting in upregulated A-to-I editing on the same m6A-depleted transcripts. Inhibition of METTL3 enhances ADAR1-mediated A-to-I editing of Mitochondrial import inner membrane translocase subunit TIM50 (TIMM50) by reducing its m6A modification."	.	29304330	.
M6ACROT00008	REG00007	M6ATAR01522	RNA modification / A-to-I	EPIREG00002	EPITAR00007	.	.	m6A	Direct	Inhibition	A-to-I	m6A modification directly impacts RNA modification through targeting the shared RNA	"Both the presence and extent of A-to-I sites in m6A-negative RNA transcripts suggest a negative correlation between m6A and A-to-I. Suppression of m6A-catalyzing enzymes results in global A-to-I RNA editing changes. Further depletion of m6A modification increases the association of m6A-depleted transcripts with adenosine deaminase acting on RNA (ADAR) enzymes, resulting in upregulated A-to-I editing on the same m6A-depleted transcripts. Inhibition of METTL3 enhances ADAR1-mediated A-to-I editing of Protein-S-isoprenylcysteine O-methyltransferase (ICMT) by reducing its m6A modification."	.	29304330	.
M6ACROT00009	REG00007	M6ATAR01523	RNA modification / A-to-I	EPIREG00002	EPITAR00008	.	.	m6A	Direct	Inhibition	A-to-I	m6A modification directly impacts RNA modification through targeting the shared RNA	"Both the presence and extent of A-to-I sites in m6A-negative RNA transcripts suggest a negative correlation between m6A and A-to-I. Suppression of m6A-catalyzing enzymes results in global A-to-I RNA editing changes. Further depletion of m6A modification increases the association of m6A-depleted transcripts with adenosine deaminase acting on RNA (ADAR) enzymes, resulting in upregulated A-to-I editing on the same m6A-depleted transcripts. Inhibition of METTL3 enhances ADAR1-mediated A-to-I editing of Interleukin-17 receptor D (IL17RD) by reducing its m6A modification."	.	29304330	.
M6ACROT00010	REG00007	M6ATAR01524	RNA modification / A-to-I	EPIREG00002	EPITAR00009	.	.	m6A	Direct	Inhibition	A-to-I	m6A modification directly impacts RNA modification through targeting the shared RNA	"Both the presence and extent of A-to-I sites in m6A-negative RNA transcripts suggest a negative correlation between m6A and A-to-I. Suppression of m6A-catalyzing enzymes results in global A-to-I RNA editing changes. Further depletion of m6A modification increases the association of m6A-depleted transcripts with adenosine deaminase acting on RNA (ADAR) enzymes, resulting in upregulated A-to-I editing on the same m6A-depleted transcripts. Inhibition of METTL3 enhances ADAR1-mediated A-to-I editing of Gap junction gamma-1 protein (GJC1) by reducing its m6A modification."	.	29304330	M6ADRUG0219
M6ACROT00011	REG00007	M6ATAR01525	RNA modification / m7G	EPIREG00003	EPITAR00010	.	Up regulation	m6A	Direct	Enhancement	m7G	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	m6A methyltransferase METTL3-mediated Methyltransferase-like protein 1 (METTL1) promotes cell proliferation of head and neck squamous cell carcinoma (HNSC) through m7G modification of the cell-cycle regulator Cyclin-dependent kinase 4 (CDK4).	M6ADIS0035	37694982	M6ADRUG0224
M6ACROT00012	REG00007	M6ATAR00493	RNA modification / m5C	EPIREG00004	EPITAR00011	.	Down regulation	m5C	Indirect	Inhibition	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"The 5-methylcytosine (m5C) methyltransferase NSUN2 interacts with NF-kappaB interacting lncRNA (NKILA), increasing its m5C level and promoting its interaction with YBX1. Moreover, NKILA physically interacted with and suppressed hsa-miR-582-3p, which was regulated by METTL3-mediated N6-methyladenosine (m6A) modification."	M6ADIS0006	35274813	.
M6ACROT00013	REG00007	M6ATAR00493	RNA modification / m5C	EPIREG00001	EPITAR00011	.	Down regulation	m5C	Indirect	Inhibition	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"The 5-methylcytosine (m5C) methyltransferase NSUN2 interacts with NF-kappaB interacting lncRNA (NKILA), increasing its m5C level and promoting its interaction with YBX1. Moreover, NKILA physically interacted with and suppressed hsa-miR-582-3p, which was regulated by METTL3-mediated N6-methyladenosine (m6A) modification."	M6ADIS0006	35274813	.
M6ACROT00014	REG00021	M6ATAR01414	RNA modification / m5C	EPIREG00005	EPITAR00012	.	Up regulation	m5C	Direct	Enhancement	m6A	RNA modification directly impacts m6A modification through recruiting m6A regulator and targeting the shared RNA	RBM15B- and IGFBP2-mediated N6-methyladenosine (m6A) modification and NSUN5-mediated 5-methylcytosine (m5C) modification of Phospholipid hydroperoxide glutathione peroxidase GPX4 (GPX4) facilitated anticancer immunity via activation of cyclic GMP-AMP synthase (cGAS)-stimulator of interferon (STING) signaling by maintaining redox homeostasis in COAD.	M6ADIS0058	38065948	.
M6ACROT00015	REG00034	M6ATAR01414	RNA modification / m5C	EPIREG00005	EPITAR00012	.	Up regulation	m5C	Direct	Enhancement	m6A	RNA modification directly impacts m6A modification through recruiting m6A regulator and targeting the shared RNA	RBM15B- and IGFBP2-mediated N6-methyladenosine (m6A) modification and NSUN5-mediated 5-methylcytosine (m5C) modification of Phospholipid hydroperoxide glutathione peroxidase GPX4 (GPX4) facilitated anticancer immunity via activation of cyclic GMP-AMP synthase (cGAS)-stimulator of interferon (STING) signaling by maintaining redox homeostasis in COAD.	M6ADIS0058	38065948	.
M6ACROT00016	REG00001	M6ATAR00353	RNA modification / m5C	EPIREG00001	EPITAR00013	.	Down regulation	m6A	Direct	Inhibition	m5C	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"FTO overexpression inhibited RA by inhibiting the expression of RNA cytosine C(5)-methyltransferase NSUN2 (NSUN2), up-regulating the level of Secreted frizzled related protein 1 (SFRP1) protein, and blocking the Wnt/beta-catenin signaling pathway."	M6ADIS0112	38243394	.
M6ACROT00017	REG00008	M6ATAR00705	RNA modification / m1A	EPIREG00006	EPITAR00014	.	Up regulation	m1A	Direct	Enhancement	m6A	RNA modification directly impacts m6A modification through recruiting m6A regulator and targeting the shared RNA	A subset of endogenous RNAs (Ubiquitin domain-containing protein TINC (TINCR); cMATR3; cFAM20B and cSLC45A4) that harbor m6A and associate with YTHDF2 in an HRSP12-dependent manner is also subjected to m1A-facilitated rapid degradation. The m1A modification is mediated by the TRMT6/TRMT61A complex.	.	36070699	.
M6ACROT00018	REG00008	M6ATAR00705	RNA modification / m1A	EPIREG00007	EPITAR00014	.	Up regulation	m1A	Direct	Enhancement	m6A	RNA modification directly impacts m6A modification through recruiting m6A regulator and targeting the shared RNA	A subset of endogenous RNAs (Ubiquitin domain-containing protein TINC (TINCR); cMATR3; cFAM20B and cSLC45A4) that harbor m6A and associate with YTHDF2 in an HRSP12-dependent manner is also subjected to m1A-facilitated rapid degradation. The m1A modification is mediated by the TRMT6/TRMT61A complex.	.	36070699	.
M6ACROT00019	REG00008	M6ATAR00814	RNA modification / m1A	EPIREG00006	EPITAR00015	.	Up regulation	m1A	Direct	Enhancement	m6A	RNA modification directly impacts m6A modification through recruiting m6A regulator and targeting the shared RNA	A subset of endogenous RNAs (Protein SON; cMATR3; cFAM20B and cSLC45A4) that harbor m6A and associate with YTHDF2 in an HRSP12-dependent manner is also subjected to m1A-facilitated rapid degradation. The m1A modification is mediated by the TRMT6/TRMT61A complex.	.	36070699	.
M6ACROT00020	REG00008	M6ATAR00814	RNA modification / m1A	EPIREG00007	EPITAR00015	.	Up regulation	m1A	Direct	Enhancement	m6A	RNA modification directly impacts m6A modification through recruiting m6A regulator and targeting the shared RNA	A subset of endogenous RNAs (Protein SON; cMATR3; cFAM20B and cSLC45A4) that harbor m6A and associate with YTHDF2 in an HRSP12-dependent manner is also subjected to m1A-facilitated rapid degradation. The m1A modification is mediated by the TRMT6/TRMT61A complex.	.	36070699	.
M6ACROT00021	REG00008	M6ATAR00803	RNA modification / m1A	EPIREG00006	EPITAR00016	.	Up regulation	m1A	Direct	Enhancement	m6A	RNA modification directly impacts m6A modification through recruiting m6A regulator and targeting the shared RNA	A subset of endogenous RNAs (Circ_MATR3; cFAM20B and cSLC45A4) that harbor m6A and associate with YTHDF2 in an HRSP12-dependent manner is also subjected to m1A-facilitated rapid degradation. The m1A modification is mediated by the TRMT6/TRMT61A complex.	.	36070699	.
M6ACROT00022	REG00008	M6ATAR00803	RNA modification / m1A	EPIREG00007	EPITAR00016	.	Up regulation	m1A	Direct	Enhancement	m6A	RNA modification directly impacts m6A modification through recruiting m6A regulator and targeting the shared RNA	A subset of endogenous RNAs (Circ_MATR3; cFAM20B and cSLC45A4) that harbor m6A and associate with YTHDF2 in an HRSP12-dependent manner is also subjected to m1A-facilitated rapid degradation. The m1A modification is mediated by the TRMT6/TRMT61A complex.	.	36070699	.
M6ACROT00023	REG00008	M6ATAR00804	RNA modification / m1A	EPIREG00006	EPITAR00017	.	Up regulation	m1A	Direct	Enhancement	m6A	RNA modification directly impacts m6A modification through recruiting m6A regulator and targeting the shared RNA	A subset of endogenous RNAs (cMATR3; Circ_FAM20B and cSLC45A4) that harbor m6A and associate with YTHDF2 in an HRSP12-dependent manner is also subjected to m1A-facilitated rapid degradation. The m1A modification is mediated by the TRMT6/TRMT61A complex.	.	36070699	.
M6ACROT00024	REG00008	M6ATAR00804	RNA modification / m1A	EPIREG00007	EPITAR00017	.	Up regulation	m1A	Direct	Enhancement	m6A	RNA modification directly impacts m6A modification through recruiting m6A regulator and targeting the shared RNA	A subset of endogenous RNAs (cMATR3; Circ_FAM20B and cSLC45A4) that harbor m6A and associate with YTHDF2 in an HRSP12-dependent manner is also subjected to m1A-facilitated rapid degradation. The m1A modification is mediated by the TRMT6/TRMT61A complex.	.	36070699	.
M6ACROT00025	REG00008	M6ATAR00805	RNA modification / m1A	EPIREG00006	EPITAR00018	.	Up regulation	m1A	Direct	Enhancement	m6A	RNA modification directly impacts m6A modification through recruiting m6A regulator and targeting the shared RNA	A subset of endogenous RNAs (cMATR3; cFAM20B and Circ_SLC45A4) that harbor m6A and associate with YTHDF2 in an HRSP12-dependent manner is also subjected to m1A-facilitated rapid degradation. The m1A modification is mediated by the TRMT6/TRMT61A complex.	.	36070699	.
M6ACROT00026	REG00008	M6ATAR00805	RNA modification / m1A	EPIREG00007	EPITAR00018	.	Up regulation	m1A	Direct	Enhancement	m6A	RNA modification directly impacts m6A modification through recruiting m6A regulator and targeting the shared RNA	A subset of endogenous RNAs (cMATR3; cFAM20B and Circ_SLC45A4) that harbor m6A and associate with YTHDF2 in an HRSP12-dependent manner is also subjected to m1A-facilitated rapid degradation. The m1A modification is mediated by the TRMT6/TRMT61A complex.	.	36070699	.
M6ACROT00027	REG00001	M6ATAR00341	RNA modification / m1G	EPIREG00008	EPITAR00019	.	Down regulation	m1G	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"TRMT10A ablation not only leads to decreased m1G in tRNA (TRNA-Gln (anticodon TTG) 1-1 (TRQ-TTG1-1); tRNAArg (CCG) and tRNAThr (CGT)) but also significantly increases m6A levels in mRNA. Cross-linking and immunoprecipitation, followed by high-throughput sequencing results show that TRMT10A shares a significant overlap of associated mRNAs with FTO, and these mRNAs (Myc proto-oncogene protein (MYC); FOXD1 and AUPKAIP1) have accelerated decay rates potentially through the regulation by a specific m6A reader, YTHDF2."	.	32213595	M6ADRUG0220
M6ACROT00028	REG00008	M6ATAR00341	RNA modification / m1G	EPIREG00008	EPITAR00019	.	Down regulation	m1G	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"TRMT10A ablation not only leads to decreased m1G in tRNA (TRNA-Gln (anticodon TTG) 1-1 (TRQ-TTG1-1); tRNAArg (CCG) and tRNAThr (CGT)) but also significantly increases m6A levels in mRNA. Cross-linking and immunoprecipitation, followed by high-throughput sequencing results show that TRMT10A shares a significant overlap of associated mRNAs with FTO, and these mRNAs (Myc proto-oncogene protein (MYC); FOXD1 and AUPKAIP1) have accelerated decay rates potentially through the regulation by a specific m6A reader, YTHDF2."	.	32213595	M6ADRUG0220
M6ACROT00029	REG00001	M6ATAR00341	RNA modification / m1G	EPIREG00008	EPITAR00020	.	Down regulation	m1G	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"TRMT10A ablation not only leads to decreased m1G in tRNA (tRNAGln (TTG); TRNA-Arg (anticodon CCG) 1-1 (TRR-CCG1-1) and tRNAThr (CGT)) but also significantly increases m6A levels in mRNA. Cross-linking and immunoprecipitation, followed by high-throughput sequencing results show that TRMT10A shares a significant overlap of associated mRNAs with FTO, and these mRNAs (Myc proto-oncogene protein (MYC); FOXD1 and AUPKAIP1) have accelerated decay rates potentially through the regulation by a specific m6A reader, YTHDF2."	.	32213595	M6ADRUG0220
M6ACROT00030	REG00008	M6ATAR00341	RNA modification / m1G	EPIREG00008	EPITAR00020	.	Down regulation	m1G	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"TRMT10A ablation not only leads to decreased m1G in tRNA (tRNAGln (TTG); TRNA-Arg (anticodon CCG) 1-1 (TRR-CCG1-1) and tRNAThr (CGT)) but also significantly increases m6A levels in mRNA. Cross-linking and immunoprecipitation, followed by high-throughput sequencing results show that TRMT10A shares a significant overlap of associated mRNAs with FTO, and these mRNAs (Myc proto-oncogene protein (MYC); FOXD1 and AUPKAIP1) have accelerated decay rates potentially through the regulation by a specific m6A reader, YTHDF2."	.	32213595	M6ADRUG0220
M6ACROT00031	REG00001	M6ATAR00341	RNA modification / m1G	EPIREG00008	EPITAR00021	.	Down regulation	m1G	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"TRMT10A ablation not only leads to decreased m1G in tRNA (tRNAGln (TTG); tRNAArg (CCG) and TRNA-Thr (anticodon CGT) 1-1 (TRT-CGT1-1)) but also significantly increases m6A levels in mRNA. Cross-linking and immunoprecipitation, followed by high-throughput sequencing results show that TRMT10A shares a significant overlap of associated mRNAs with FTO, and these mRNAs (Myc proto-oncogene protein (MYC); FOXD1 and AUPKAIP1) have accelerated decay rates potentially through the regulation by a specific m6A reader, YTHDF2."	.	32213595	M6ADRUG0220
M6ACROT00032	REG00008	M6ATAR00341	RNA modification / m1G	EPIREG00008	EPITAR00021	.	Down regulation	m1G	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"TRMT10A ablation not only leads to decreased m1G in tRNA (tRNAGln (TTG); tRNAArg (CCG) and TRNA-Thr (anticodon CGT) 1-1 (TRT-CGT1-1)) but also significantly increases m6A levels in mRNA. Cross-linking and immunoprecipitation, followed by high-throughput sequencing results show that TRMT10A shares a significant overlap of associated mRNAs with FTO, and these mRNAs (Myc proto-oncogene protein (MYC); FOXD1 and AUPKAIP1) have accelerated decay rates potentially through the regulation by a specific m6A reader, YTHDF2."	.	32213595	M6ADRUG0220
M6ACROT00033	REG00001	M6ATAR00257	RNA modification / m1G	EPIREG00008	EPITAR00019	.	Down regulation	m1G	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"TRMT10A ablation not only leads to decreased m1G in tRNA (TRNA-Gln (anticodon TTG) 1-1 (TRQ-TTG1-1); tRNAArg (CCG) and tRNAThr (CGT)) but also significantly increases m6A levels in mRNA. Cross-linking and immunoprecipitation, followed by high-throughput sequencing results show that TRMT10A shares a significant overlap of associated mRNAs with FTO, and these mRNAs (MYC; Forkhead box protein D1 (FOXD1) and AUPKAIP1) have accelerated decay rates potentially through the regulation by a specific m6A reader, YTHDF2."	.	32213595	.
M6ACROT00034	REG00008	M6ATAR00257	RNA modification / m1G	EPIREG00008	EPITAR00019	.	Down regulation	m1G	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"TRMT10A ablation not only leads to decreased m1G in tRNA (TRNA-Gln (anticodon TTG) 1-1 (TRQ-TTG1-1); tRNAArg (CCG) and tRNAThr (CGT)) but also significantly increases m6A levels in mRNA. Cross-linking and immunoprecipitation, followed by high-throughput sequencing results show that TRMT10A shares a significant overlap of associated mRNAs with FTO, and these mRNAs (MYC; Forkhead box protein D1 (FOXD1) and AUPKAIP1) have accelerated decay rates potentially through the regulation by a specific m6A reader, YTHDF2."	.	32213595	.
M6ACROT00035	REG00001	M6ATAR00257	RNA modification / m1G	EPIREG00008	EPITAR00020	.	Down regulation	m1G	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"TRMT10A ablation not only leads to decreased m1G in tRNA (tRNAGln (TTG); TRNA-Arg (anticodon CCG) 1-1 (TRR-CCG1-1) and tRNAThr (CGT)) but also significantly increases m6A levels in mRNA. Cross-linking and immunoprecipitation, followed by high-throughput sequencing results show that TRMT10A shares a significant overlap of associated mRNAs with FTO, and these mRNAs (MYC; Forkhead box protein D1 (FOXD1) and AUPKAIP1) have accelerated decay rates potentially through the regulation by a specific m6A reader, YTHDF2."	.	32213595	.
M6ACROT00036	REG00008	M6ATAR00257	RNA modification / m1G	EPIREG00008	EPITAR00020	.	Down regulation	m1G	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"TRMT10A ablation not only leads to decreased m1G in tRNA (tRNAGln (TTG); TRNA-Arg (anticodon CCG) 1-1 (TRR-CCG1-1) and tRNAThr (CGT)) but also significantly increases m6A levels in mRNA. Cross-linking and immunoprecipitation, followed by high-throughput sequencing results show that TRMT10A shares a significant overlap of associated mRNAs with FTO, and these mRNAs (MYC; Forkhead box protein D1 (FOXD1) and AUPKAIP1) have accelerated decay rates potentially through the regulation by a specific m6A reader, YTHDF2."	.	32213595	.
M6ACROT00037	REG00001	M6ATAR00257	RNA modification / m1G	EPIREG00008	EPITAR00021	.	Down regulation	m1G	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"TRMT10A ablation not only leads to decreased m1G in tRNA (tRNAGln (TTG); tRNAArg (CCG) and TRNA-Thr (anticodon CGT) 1-1 (TRT-CGT1-1)) but also significantly increases m6A levels in mRNA. Cross-linking and immunoprecipitation, followed by high-throughput sequencing results show that TRMT10A shares a significant overlap of associated mRNAs with FTO, and these mRNAs (MYC; Forkhead box protein D1 (FOXD1) and AUPKAIP1) have accelerated decay rates potentially through the regulation by a specific m6A reader, YTHDF2."	.	32213595	.
M6ACROT00038	REG00008	M6ATAR00257	RNA modification / m1G	EPIREG00008	EPITAR00021	.	Down regulation	m1G	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"TRMT10A ablation not only leads to decreased m1G in tRNA (tRNAGln (TTG); tRNAArg (CCG) and TRNA-Thr (anticodon CGT) 1-1 (TRT-CGT1-1)) but also significantly increases m6A levels in mRNA. Cross-linking and immunoprecipitation, followed by high-throughput sequencing results show that TRMT10A shares a significant overlap of associated mRNAs with FTO, and these mRNAs (MYC; Forkhead box protein D1 (FOXD1) and AUPKAIP1) have accelerated decay rates potentially through the regulation by a specific m6A reader, YTHDF2."	.	32213595	.
M6ACROT00039	REG00001	M6ATAR01527	RNA modification / m1G	EPIREG00008	EPITAR00019	.	Down regulation	m1G	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"TRMT10A ablation not only leads to decreased m1G in tRNA (TRNA-Gln (anticodon TTG) 1-1 (TRQ-TTG1-1); tRNAArg (CCG) and tRNAThr (CGT)) but also significantly increases m6A levels in mRNA. Cross-linking and immunoprecipitation, followed by high-throughput sequencing results show that TRMT10A shares a significant overlap of associated mRNAs with FTO, and these mRNAs (MYC; FOXD1 and Small ribosomal subunit protein mS38 (AURKAIP1)) have accelerated decay rates potentially through the regulation by a specific m6A reader, YTHDF2."	.	32213595	.
M6ACROT00040	REG00008	M6ATAR01527	RNA modification / m1G	EPIREG00008	EPITAR00019	.	Down regulation	m1G	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"TRMT10A ablation not only leads to decreased m1G in tRNA (TRNA-Gln (anticodon TTG) 1-1 (TRQ-TTG1-1); tRNAArg (CCG) and tRNAThr (CGT)) but also significantly increases m6A levels in mRNA. Cross-linking and immunoprecipitation, followed by high-throughput sequencing results show that TRMT10A shares a significant overlap of associated mRNAs with FTO, and these mRNAs (MYC; FOXD1 and Small ribosomal subunit protein mS38 (AURKAIP1)) have accelerated decay rates potentially through the regulation by a specific m6A reader, YTHDF2."	.	32213595	.
M6ACROT00041	REG00001	M6ATAR01527	RNA modification / m1G	EPIREG00008	EPITAR00020	.	Down regulation	m1G	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"TRMT10A ablation not only leads to decreased m1G in tRNA (tRNAGln (TTG); TRNA-Arg (anticodon CCG) 1-1 (TRR-CCG1-1) and tRNAThr (CGT)) but also significantly increases m6A levels in mRNA. Cross-linking and immunoprecipitation, followed by high-throughput sequencing results show that TRMT10A shares a significant overlap of associated mRNAs with FTO, and these mRNAs (MYC; FOXD1 and Small ribosomal subunit protein mS38 (AURKAIP1)) have accelerated decay rates potentially through the regulation by a specific m6A reader, YTHDF2."	.	32213595	.
M6ACROT00042	REG00008	M6ATAR01527	RNA modification / m1G	EPIREG00008	EPITAR00020	.	Down regulation	m1G	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"TRMT10A ablation not only leads to decreased m1G in tRNA (tRNAGln (TTG); TRNA-Arg (anticodon CCG) 1-1 (TRR-CCG1-1) and tRNAThr (CGT)) but also significantly increases m6A levels in mRNA. Cross-linking and immunoprecipitation, followed by high-throughput sequencing results show that TRMT10A shares a significant overlap of associated mRNAs with FTO, and these mRNAs (MYC; FOXD1 and Small ribosomal subunit protein mS38 (AURKAIP1)) have accelerated decay rates potentially through the regulation by a specific m6A reader, YTHDF2."	.	32213595	.
M6ACROT00043	REG00001	M6ATAR01527	RNA modification / m1G	EPIREG00008	EPITAR00021	.	Down regulation	m1G	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"TRMT10A ablation not only leads to decreased m1G in tRNA (tRNAGln (TTG); tRNAArg (CCG) and TRNA-Thr (anticodon CGT) 1-1 (TRT-CGT1-1)) but also significantly increases m6A levels in mRNA. Cross-linking and immunoprecipitation, followed by high-throughput sequencing results show that TRMT10A shares a significant overlap of associated mRNAs with FTO, and these mRNAs (MYC; FOXD1 and Small ribosomal subunit protein mS38 (AURKAIP1)) have accelerated decay rates potentially through the regulation by a specific m6A reader, YTHDF2."	.	32213595	.
M6ACROT00044	REG00008	M6ATAR01527	RNA modification / m1G	EPIREG00008	EPITAR00021	.	Down regulation	m1G	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"TRMT10A ablation not only leads to decreased m1G in tRNA (tRNAGln (TTG); tRNAArg (CCG) and TRNA-Thr (anticodon CGT) 1-1 (TRT-CGT1-1)) but also significantly increases m6A levels in mRNA. Cross-linking and immunoprecipitation, followed by high-throughput sequencing results show that TRMT10A shares a significant overlap of associated mRNAs with FTO, and these mRNAs (MYC; FOXD1 and Small ribosomal subunit protein mS38 (AURKAIP1)) have accelerated decay rates potentially through the regulation by a specific m6A reader, YTHDF2."	.	32213595	.
M6ACROT00045	REG00001	M6ATAR00341	RNA modification / m1G	EPIREG00008	EPITAR00022	.	Down regulation	m1G	Direct	Enhancement	m6A	RNA modification directly impacts m6A modification through recruiting m6A regulator and targeting the shared RNA	TRMT10A may enhance FTO's demethylation activity and selectivity on m6A sites in poly(A)-RNA (Myc proto-oncogene protein (MYC); FOXD1; AUPKAIP1; ATP7A and ERCC5).	.	32213595	M6ADRUG0220
M6ACROT00046	REG00001	M6ATAR00257	RNA modification / m1G	EPIREG00008	EPITAR00023	.	Down regulation	m1G	Direct	Enhancement	m6A	RNA modification directly impacts m6A modification through recruiting m6A regulator and targeting the shared RNA	TRMT10A may enhance FTO's demethylation activity and selectivity on m6A sites in poly(A)-RNA (MYC; Forkhead box protein D1 (FOXD1); AUPKAIP1; ATP7A and ERCC5).	.	32213595	.
M6ACROT00047	REG00001	M6ATAR01527	RNA modification / m1G	EPIREG00008	EPITAR00024	.	Down regulation	m1G	Direct	Enhancement	m6A	RNA modification directly impacts m6A modification through recruiting m6A regulator and targeting the shared RNA	TRMT10A may enhance FTO's demethylation activity and selectivity on m6A sites in poly(A)-RNA (MYC; FOXD1; Small ribosomal subunit protein mS38 (AURKAIP1); ATP7A and ERCC5).	.	32213595	.
M6ACROT00048	REG00001	M6ATAR01528	RNA modification / m1G	EPIREG00008	EPITAR00025	.	Down regulation	m1G	Direct	Enhancement	m6A	RNA modification directly impacts m6A modification through recruiting m6A regulator and targeting the shared RNA	TRMT10A may enhance FTO's demethylation activity and selectivity on m6A sites in poly(A)-RNA (MYC; FOXD1; AUPKAIP1; Copper-transporting ATPase 1 (ATP7A) and ERCC5).	.	32213595	.
M6ACROT00049	REG00001	M6ATAR01529	RNA modification / m1G	EPIREG00008	EPITAR00026	.	Down regulation	m1G	Direct	Enhancement	m6A	RNA modification directly impacts m6A modification through recruiting m6A regulator and targeting the shared RNA	TRMT10A may enhance FTO's demethylation activity and selectivity on m6A sites in poly(A)-RNA (MYC; FOXD1; AUPKAIP1; ATP7A and DNA excision repair protein ERCC-5 (ERCC5)).	.	32213595	.
M6ACROT00050	REG00007	M6ATAR01418	RNA modification / m1A	EPIREG00009	EPITAR00027	.	Up regulation	m1A	Direct	Enhancement	m6A	RNA modification directly impacts m6A modification through modulating the expression level of m6A regulator	"ALKBH3 recognizes the m1A methylation sites and prevents YTHDF2-dependent mRNA decay of METTL3 transcript. Subsequently, METTL3 stabilizes Collagen alpha-1 (COL1A1) and FN1 mRNAs in a YTHDF1-dependent manner, two major components of extracellular matrix, and therefore eliciting the pathological transformation of HTS. This observation bridges the understanding of the link between m1A and m6A methylation, the two fundamental RNA modifications, underscoring the participation of ""RNA methylation crosstalk"" in pathological events."	M6ADIS0132	40019372	.
M6ACROT00051	REG00007	M6ATAR01530	RNA modification / m1A	EPIREG00009	EPITAR00027	.	Up regulation	m1A	Direct	Enhancement	m6A	RNA modification directly impacts m6A modification through modulating the expression level of m6A regulator	"ALKBH3 recognizes the m1A methylation sites and prevents YTHDF2-dependent mRNA decay of METTL3 transcript. Subsequently, METTL3 stabilizes COL1A1 and Fibronectin (FN1) mRNAs in a YTHDF1-dependent manner, two major components of extracellular matrix, and therefore eliciting the pathological transformation of HTS. This observation bridges the understanding of the link between m1A and m6A methylation, the two fundamental RNA modifications, underscoring the participation of ""RNA methylation crosstalk"" in pathological events."	M6ADIS0132	40019372	M6ADRUG0221
M6ACROT00052	REG00007	M6ATAR01418	RNA modification / m1A	EPIREG00010	EPITAR00027	.	Up regulation	m1A	Direct	Inhibition	m6A	RNA modification directly impacts m6A modification through modulating the expression level of m6A regulator	"ALKBH3 recognizes the m1A methylation sites and prevents YTHDF2-dependent mRNA decay of METTL3 transcript. Subsequently, METTL3 stabilizes Collagen alpha-1 (COL1A1) and FN1 mRNAs in a YTHDF1-dependent manner, two major components of extracellular matrix, and therefore eliciting the pathological transformation of HTS. This observation bridges the understanding of the link between m1A and m6A methylation, the two fundamental RNA modifications, underscoring the participation of ""RNA methylation crosstalk"" in pathological events."	M6ADIS0132	40019372	.
M6ACROT00053	REG00007	M6ATAR01530	RNA modification / m1A	EPIREG00010	EPITAR00027	.	Up regulation	m1A	Direct	Inhibition	m6A	RNA modification directly impacts m6A modification through modulating the expression level of m6A regulator	"ALKBH3 recognizes the m1A methylation sites and prevents YTHDF2-dependent mRNA decay of METTL3 transcript. Subsequently, METTL3 stabilizes COL1A1 and Fibronectin (FN1) mRNAs in a YTHDF1-dependent manner, two major components of extracellular matrix, and therefore eliciting the pathological transformation of HTS. This observation bridges the understanding of the link between m1A and m6A methylation, the two fundamental RNA modifications, underscoring the participation of ""RNA methylation crosstalk"" in pathological events."	M6ADIS0132	40019372	M6ADRUG0221
M6ACROT00054	REG00024	M6ATAR01418	RNA modification / m1A	EPIREG00009	EPITAR00027	.	Up regulation	m1A	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ALKBH3 recognizes the m1A methylation sites and prevents YTHDF2-dependent mRNA decay of Methyltransferase-like protein 3 (METTL3) transcript. Subsequently, METTL3 stabilizes Collagen alpha-1 (COL1A1) and FN1 mRNAs in a YTHDF1-dependent manner, two major components of extracellular matrix, and therefore eliciting the pathological transformation of HTS. This observation bridges the understanding of the link between m1A and m6A methylation, the two fundamental RNA modifications, underscoring the participation of ""RNA methylation crosstalk"" in pathological events."	M6ADIS0132	40019372	.
M6ACROT00055	REG00024	M6ATAR01530	RNA modification / m1A	EPIREG00009	EPITAR00027	.	Up regulation	m1A	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ALKBH3 recognizes the m1A methylation sites and prevents YTHDF2-dependent mRNA decay of Methyltransferase-like protein 3 (METTL3) transcript. Subsequently, METTL3 stabilizes COL1A1 and Fibronectin (FN1) mRNAs in a YTHDF1-dependent manner, two major components of extracellular matrix, and therefore eliciting the pathological transformation of HTS. This observation bridges the understanding of the link between m1A and m6A methylation, the two fundamental RNA modifications, underscoring the participation of ""RNA methylation crosstalk"" in pathological events."	M6ADIS0132	40019372	M6ADRUG0221
M6ACROT00056	REG00024	M6ATAR01418	RNA modification / m1A	EPIREG00010	EPITAR00027	.	Up regulation	m1A	Indirect	Inhibition	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ALKBH3 recognizes the m1A methylation sites and prevents YTHDF2-dependent mRNA decay of Methyltransferase-like protein 3 (METTL3) transcript. Subsequently, METTL3 stabilizes Collagen alpha-1 (COL1A1) and FN1 mRNAs in a YTHDF1-dependent manner, two major components of extracellular matrix, and therefore eliciting the pathological transformation of HTS. This observation bridges the understanding of the link between m1A and m6A methylation, the two fundamental RNA modifications, underscoring the participation of ""RNA methylation crosstalk"" in pathological events."	M6ADIS0132	40019372	.
M6ACROT00057	REG00024	M6ATAR01530	RNA modification / m1A	EPIREG00010	EPITAR00027	.	Up regulation	m1A	Indirect	Inhibition	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ALKBH3 recognizes the m1A methylation sites and prevents YTHDF2-dependent mRNA decay of Methyltransferase-like protein 3 (METTL3) transcript. Subsequently, METTL3 stabilizes COL1A1 and Fibronectin (FN1) mRNAs in a YTHDF1-dependent manner, two major components of extracellular matrix, and therefore eliciting the pathological transformation of HTS. This observation bridges the understanding of the link between m1A and m6A methylation, the two fundamental RNA modifications, underscoring the participation of ""RNA methylation crosstalk"" in pathological events."	M6ADIS0132	40019372	M6ADRUG0221
M6ACROT00058	REG00013	M6ATAR01531	RNA modification / 2'-O-methylation	EPIREG00011	EPITAR00028	.	Up regulation	2'-O-methylation	Direct	Enhancement	m6A	RNA modification directly impacts m6A modification through modulating the expression level of m6A regulator	"SNORD9 induces Nuclear transcription factor Y subunit alpha (NFYA) m6A methylation by binding to m6A methylase METTL3; modifying IGF2BP2 mRNA by FBL-dependet 2'-O-methylation and improve NFYA mRNA stability, thus promote the tumorigenesis of ovarian cancer. Targeting ASO to SNORD9 may have efficacy in the treatment of ovarian cancer."	M6ADIS0066	40044032	.
M6ACROT00059	REG00012	M6ATAR01532	RNA modification / 2'-O-methylation	EPIREG00012	EPITAR00029	.	Up regulation	m6A	Indirect	Enhancement	2'-O-methylation	m6A modification directly impacts RNA modification through downstream signaling pathways	"IGF2BP1 upregulated MIR4435-2 host gene (MIR4435-2HG) expression in HCC through N6-methyladenosine (m6A) modification. Moreover, MIR4435-2HG protected NOP58 from degradation, which raised rRNA 2'-O-Me levels and promoted internal ribosome entry site (IRES)-dependent translation of oncogenes."	M6ADIS0006	37891494	.
M6ACROT00060	REG00024	M6ATAR00536	RNA modification / A-to-I	EPIREG00002	EPITAR00030	.	Up regulation	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"The A-to-I RNA editing activity of Interferon-inducible protein 4 (ADAR1) plays important roles in the YTHDF1-dependent IFN responses. Therefore, m6A and YTHDF1 affect innate immune responses through modulating the ADAR1-mediated A-to-I RNA editing of mRNA (Tankyrase (TNKS); EIF2AK2 and PSMB2)."	.	34324489	M6ADRUG0225
M6ACROT00061	REG00024	M6ATAR00536	RNA modification / A-to-I	EPIREG00002	EPITAR00002	.	Up regulation	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"The A-to-I RNA editing activity of Interferon-inducible protein 4 (ADAR1) plays important roles in the YTHDF1-dependent IFN responses. Therefore, m6A and YTHDF1 affect innate immune responses through modulating the ADAR1-mediated A-to-I RNA editing of mRNA (TNKS; Tyrosine-protein kinase EIF2AK2 (eIF2AK2/p68) and PSMB2)."	.	34324489	M6ADRUG0218
M6ACROT00062	REG00024	M6ATAR00536	RNA modification / A-to-I	EPIREG00002	EPITAR00031	.	Up regulation	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"The A-to-I RNA editing activity of Interferon-inducible protein 4 (ADAR1) plays important roles in the YTHDF1-dependent IFN responses. Therefore, m6A and YTHDF1 affect innate immune responses through modulating the ADAR1-mediated A-to-I RNA editing of mRNA (TNKS; EIF2AK2 and Proteasome 20S subunit beta 2 (PSMB2))."	.	34324489	.
M6ACROT00063	REG00007	M6ATAR00536	RNA modification / A-to-I	EPIREG00002	EPITAR00032	.	Up regulation	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3, upregulated in glioblastoma, methylates Interferon-inducible protein 4 (ADAR1) mRNA and increases its protein level leading to a pro-tumorigenic mechanism connecting METTL3, YTHDF1, and ADAR1. We show that ADAR1 plays a cancer-promoting role independently of its deaminase activity by binding Cyclin-dependent kinase 2 (CDK2) mRNA, underlining the importance of ADARs as essential RNA-binding proteins for cell homeostasis as well as cancer progression. "	M6ADIS0001	33509238	M6ADRUG0226
M6ACROT00064	REG00024	M6ATAR00536	RNA modification / A-to-I	EPIREG00002	EPITAR00032	.	Up regulation	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3, upregulated in glioblastoma, methylates Interferon-inducible protein 4 (ADAR1) mRNA and increases its protein level leading to a pro-tumorigenic mechanism connecting METTL3, YTHDF1, and ADAR1. We show that ADAR1 plays a cancer-promoting role independently of its deaminase activity by binding Cyclin-dependent kinase 2 (CDK2) mRNA, underlining the importance of ADARs as essential RNA-binding proteins for cell homeostasis as well as cancer progression. "	M6ADIS0001	33509238	M6ADRUG0226
M6ACROT00065	REG00007	M6ATAR00795	RNA modification / A-to-I	EPIREG00002	EPITAR00027	.	.	A-to-I	Direct	Enhancement	m6A	RNA modification directly impacts m6A modification through modulating the expression level of m6A regulator	"overexpression and knockdown of ADAR1 respectively increased and decreased the expression levels of METTL3 and Rho GTPase activating protein 5 (ARHGAP5) protein in breast cancer. Study demonstrate that ADAR1 promotes the proliferation, migration and invasion of breast cancer cells through the METTL3/ARHGAP5/YTHDF1 axis and establish that METTL3 is one of the main targets of ADAR1 controlling biological functions."	M6ADIS0065	36077054	.
M6ACROT00066	REG00024	M6ATAR00795	RNA modification / A-to-I	EPIREG00002	EPITAR00027	.	.	A-to-I	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"overexpression and knockdown of ADAR1 respectively increased and decreased the expression levels of Methyltransferase-like protein 3 (METTL3) and Rho GTPase activating protein 5 (ARHGAP5) protein in breast cancer. Study demonstrate that ADAR1 promotes the proliferation, migration and invasion of breast cancer cells through the METTL3/ARHGAP5/YTHDF1 axis and establish that METTL3 is one of the main targets of ADAR1 controlling biological functions."	M6ADIS0065	36077054	.
M6ACROT00067	REG00007	M6ATAR01386	RNA modification / m5C	EPIREG00013	EPITAR00033	.	.	m5C	Direct	Enhancement	m6A	RNA modification directly impacts m6A modification through recruiting m6A regulator and targeting the shared RNA	"BMSCs overexpressing METTL3 and NSUN4 can promote the repair of cartilage defects in vivo. m5C and m6A co-regulate the translation of Transcription factor SOX-9 (SOX9) in a YTHDF2-dependent manner during the chondrogenic differentiation of BMSCs, which provides a therapeutic target for clinical implications."	.	35614315	.
M6ACROT00068	REG00008	M6ATAR01386	RNA modification / m5C	EPIREG00013	EPITAR00033	.	.	m6A	Direct	Enhancement	m5C	m6A modification directly impacts RNA modification through recruiting m6A regulator and targeting the shared RNA	"BMSCs overexpressing Mettl3 and NSUN4 can promote the repair of cartilage defects in vivo. m5C and m6A co-regulate the translation of Transcription factor SOX-9 (SOX9) in a YTHDF2-dependent manner during the chondrogenic differentiation of BMSCs, which provides a therapeutic target for clinical implications. "	.	35614315	.
M6ACROT00069	REG00007	M6ATAR00356	RNA modification / m5C	EPIREG00014	EPITAR00027	.	.	m5C	Direct	Enhancement	m6A	RNA modification directly impacts m6A modification through modulating the expression level of m6A regulator	"NSUN6 upregulates the expression of oncogenic METTL3 and catalyzes its m5C modification in COAD cells. Overexpression of METTL3 significantly relieved the cell cycle inhibition of COAD caused by NSUN6 deficiency. Either silencing METTL3 expression by using small interfering RNA (siRNA) or inhibiting RNA methylation with neplanocin A suppressed m6A formation in Cellular tumor antigen p53 (TP53/p53) pre-mRNA, and substantially increased the level of phosphorylated p53 protein (Ser15) and its function in cells heterozygously carrying the R273H mutation, thereby re-sensitizing these cells to anticancer drugs. "	M6ADIS0058	38800929; 30578760	M6ADRUG0222
M6ACROT00070	REG00007	M6ATAR00401	RNA modification / m5C	EPIREG00014	EPITAR00027	.	.	m5C	Direct	Enhancement	m6A	RNA modification directly impacts m6A modification through modulating the expression level of m6A regulator	NSUN6 upregulates the expression of oncogenic METTL3 and catalyzes its m5C modification in COAD cells. Overexpression of METTL3 significantly relieved the cell cycle inhibition of COAD caused by NSUN6 deficiency.An increased level of METTL3 may maintain the tumorigenicity of colon cancer cells by suppressing Suppressor of cytokine signaling 2 (SOCS2).	M6ADIS0058	38800929; 32705220	.
M6ACROT00071	REG00007	M6ATAR01337	RNA modification / m5C	EPIREG00014	EPITAR00027	.	.	m5C	Direct	Enhancement	m6A	RNA modification directly impacts m6A modification through modulating the expression level of m6A regulator	"NSUN6 upregulates the expression of oncogenic METTL3 and catalyzes its m5C modification in COAD cells. Overexpression of METTL3 significantly relieved the cell cycle inhibition of COAD caused by NSUN6 deficiency.METTL3 contributes to the malignant progression of COAD cells partly by regulating the stability of Cell division cycle-associated protein 7 (CDCA7) mRNA, providing a promising therapeutic target for COAD treatment"	M6ADIS0058	38800929; 38959625	.
M6ACROT00072	REG00014	M6ATAR01533	RNA modification / m5C	EPIREG00001	EPITAR00034	.	Up regulation	m5C	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"RNA cytosine-C(5)-methyltransferase (NSUN2) was upregulated in GC and high NSUN2 expression was associated with poor prognosis. TNFRSF10A divergent transcript (TNFRSF10A-DT) was identified as an NSUN2-methylated and upregulated lncRNA in GC. Functionally, NR_033928 upregulated the expression of glutaminase (Glutaminase kidney isoform, mitochondrial (GLS)) by interacting with IGF2BP3/HUR complex to promote GLS mRNA stability."	M6ADIS0057	37582794	.
M6ACROT00073	REG00002	M6ATAR00271	RNA modification / m5C	EPIREG00004	EPITAR00035	.	Up regulation	m5C	Direct	Enhancement	m6A	RNA modification directly impacts m6A modification through recruiting m6A regulator and targeting the shared RNA	"YBX1 maintains the stability of its target mRNA by recruiting ELAVL1. Moreover, NSUN2 and YBX1 are demonstrated to drive UCB pathogenesis by targeting the m5C methylation site in the Hepatoma-derived growth factor (HDGF) 3' untranslated region."	M6ADIS0070	31358969	.
M6ACROT00074	REG00002	M6ATAR00271	RNA modification / m5C	EPIREG00001	EPITAR00035	.	Up regulation	m5C	Direct	Enhancement	m6A	RNA modification directly impacts m6A modification through recruiting m6A regulator and targeting the shared RNA	"YBX1 maintains the stability of its target mRNA by recruiting ELAVL1. Moreover, NSUN2 and YBX1 are demonstrated to drive UCB pathogenesis by targeting the m5C methylation site in the Hepatoma-derived growth factor (HDGF) 3' untranslated region."	M6ADIS0070	31358969	.
M6ACROT00075	REG00012	M6ATAR01385	RNA modification / ac4C	EPIREG00015	EPITAR00036	.	Up regulation	m6A	Direct	Enhancement	ac4C	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"IGF2BP1 enhances the translation of RNA cytidine acetyltransferase (NAT10) mRNA in an m6A-dependent manner in OC cells. NAT10 drives tumorigenesis by mediating N4-acetylcytidine (ac4C) modification of Acyl-CoA thioesterase 7 (ACOT7) mRNA, thereby augmenting its stability and translation. fludarabine as a small molecule inhibitor targeting NAT10, inhibits the ac4C modification and expression of ACOT7 mRNA."	M6ADIS0066	39390256	M6ADRUG0149
M6ACROT00076	REG00007	M6ATAR00536	RNA modification / A-to-I	EPIREG00002	EPITAR00037	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Interferon-inducible protein 4 (ADAR1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADAR mediated A-to-I RNA editing of the UPF1 RNA helicase and ATPase (UPF1) transcript."	.	30781903; 33509238; 18362360	.
M6ACROT00077	REG00007	M6ATAR00536	RNA modification / A-to-I	EPIREG00002	EPITAR00038	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Interferon-inducible protein 4 (ADAR1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADAR mediated A-to-I RNA editing of the Death associated protein 3 (DAP3) transcript."	.	30781903; 33509238; 18362360	.
M6ACROT00078	REG00007	M6ATAR00536	RNA modification / A-to-I	EPIREG00002	EPITAR00039	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Interferon-inducible protein 4 (ADAR1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADAR mediated A-to-I RNA editing of the Phosphatidylserine decarboxylase (PISD) transcript."	.	30781903; 33509238; 18362360	.
M6ACROT00079	REG00007	M6ATAR00536	RNA modification / A-to-I	EPIREG00002	EPITAR00040	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Interferon-inducible protein 4 (ADAR1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADAR mediated A-to-I RNA editing of the Thioredoxin reductase 2 (TXNRD2) transcript."	.	30781903; 33509238; 18362360	.
M6ACROT00080	REG00007	M6ATAR00536	RNA modification / A-to-I	EPIREG00002	EPITAR00041	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Interferon-inducible protein 4 (ADAR1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADAR mediated A-to-I RNA editing of the BLCAP apoptosis inducing factor (BLCAP) transcript."	.	30781903; 33509238; 18407364	.
M6ACROT00081	REG00007	M6ATAR01294	RNA modification / A-to-I	EPIREG00016	EPITAR00042	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Double-stranded RNA-specific editase 1 (ADARB1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADARB1 mediated A-to-I RNA editing of the Filamin-A (FLNA) transcript."	.	30781903; 18407360	M6ADRUG0227
M6ACROT00082	REG00008	M6ATAR01294	RNA modification / A-to-I	EPIREG00016	EPITAR00042	.	.	m6A	Direct	Inhibition	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	YTHDF2 recognizes the m6A methylation sites and prevents Double-stranded RNA-specific editase 1 (ADARB1) dependent A-to-I RNA editing of Filamin-A (FLNA).	.	34324489; 18407364	M6ADRUG0227
M6ACROT00083	REG00007	M6ATAR01294	RNA modification / A-to-I	EPIREG00016	EPITAR00043	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Double-stranded RNA-specific editase 1 (ADARB1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADARB1 mediated A-to-I RNA editing of the Glutamate ionotropic receptor AMPA type subunit 2 (GRIA2) transcript."	.	30781903; 18407364; 30448461	M6ADRUG0228
M6ACROT00084	REG00008	M6ATAR01294	RNA modification / A-to-I	EPIREG00016	EPITAR00043	.	.	m6A	Direct	Inhibition	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	YTHDF2 recognizes the m6A methylation sites and prevents Double-stranded RNA-specific editase 1 (ADARB1) dependent A-to-I RNA editing of Glutamate ionotropic receptor AMPA type subunit 2 (GRIA2).	.	34324489; 18407364; 30448461	M6ADRUG0228
M6ACROT00085	REG00007	M6ATAR01294	RNA modification / A-to-I	EPIREG00016	EPITAR00044	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Double-stranded RNA-specific editase 1 (ADARB1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADARB1 mediated A-to-I RNA editing of the Cytoplasmic FMR1 interacting protein 2 (CYFIP2) transcript."	.	30781903; 18407364; 30448461	.
M6ACROT00086	REG00008	M6ATAR01294	RNA modification / A-to-I	EPIREG00016	EPITAR00044	.	.	m6A	Direct	Inhibition	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	YTHDF2 recognizes the m6A methylation sites and prevents Double-stranded RNA-specific editase 1 (ADARB1) dependent A-to-I RNA editing of Cytoplasmic FMR1 interacting protein 2 (CYFIP2).	.	34324489; 18407364; 30448461	.
M6ACROT00087	REG00007	M6ATAR00536	RNA modification / A-to-I	EPIREG00002	EPITAR00002	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Interferon-inducible protein 4 (ADAR1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADAR mediated A-to-I RNA editing of the Tyrosine-protein kinase EIF2AK2 (eIF2AK2/p68) transcript."	.	30781903; 33509238; 19733181; 31636123	M6ADRUG0218
M6ACROT00088	REG00007	M6ATAR00536	RNA modification / A-to-I	EPIREG00002	EPITAR00045	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Interferon-inducible protein 4 (ADAR1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADAR mediated A-to-I RNA editing of the Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1/eIF2-Alpha) transcript."	.	30781903; 33509238; 19733181; 31636123	.
M6ACROT00089	REG00007	M6ATAR01294	RNA modification / A-to-I	EPIREG00016	EPITAR00046	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Double-stranded RNA-specific editase 1 (ADARB1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADARB1 mediated A-to-I RNA editing of the Cell division cycle 14B (CDC14B) transcript."	.	30781903; 22525274	.
M6ACROT00090	REG00008	M6ATAR01294	RNA modification / A-to-I	EPIREG00016	EPITAR00046	.	.	m6A	Direct	Inhibition	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	YTHDF2 recognizes the m6A methylation sites and prevents Double-stranded RNA-specific editase 1 (ADARB1) dependent A-to-I RNA editing of Cell division cycle 14B (CDC14B).	.	34324489; 22525274	.
M6ACROT00091	REG00007	M6ATAR00536	RNA modification / A-to-I	EPIREG00002	EPITAR00047	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Interferon-inducible protein 4 (ADAR1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADAR mediated A-to-I RNA editing of the Antizyme inhibitor 1 (AZIN1) transcript."	.	30781903; 33509238; 23291631; 28928239; 30583079	.
M6ACROT00092	REG00007	M6ATAR00536	RNA modification / A-to-I	EPIREG00002	EPITAR00048	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Interferon-inducible protein 4 (ADAR1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADAR mediated A-to-I RNA editing of the Zinc finger protein GLI1 (GLI1) transcript."	.	30781903; 33509238; 23324600; 29203771; 33750389	M6ADRUG0229
M6ACROT00093	REG00007	M6ATAR01294	RNA modification / A-to-I	EPIREG00016	EPITAR00048	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Double-stranded RNA-specific editase 1 (ADARB1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADARB1 mediated A-to-I RNA editing of the Zinc finger protein GLI1 (GLI1) transcript."	.	30781903; 23324600	M6ADRUG0229
M6ACROT00094	REG00008	M6ATAR01294	RNA modification / A-to-I	EPIREG00016	EPITAR00048	.	.	m6A	Direct	Inhibition	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	YTHDF2 recognizes the m6A methylation sites and prevents Double-stranded RNA-specific editase 1 (ADARB1) dependent A-to-I RNA editing of Zinc finger protein GLI1 (GLI1).	.	34324489; 23324600	M6ADRUG0229
M6ACROT00095	REG00007	M6ATAR01294	RNA modification / A-to-I	EPIREG00016	EPITAR00049	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Double-stranded RNA-specific editase 1 (ADARB1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADARB1 mediated A-to-I RNA editing of the MicroRNA 16-1 (MIR16-1) transcript."	.	30781903; 23974981	.
M6ACROT00096	REG00008	M6ATAR01294	RNA modification / A-to-I	EPIREG00016	EPITAR00049	.	.	m6A	Direct	Inhibition	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	YTHDF2 recognizes the m6A methylation sites and prevents Double-stranded RNA-specific editase 1 (ADARB1) dependent A-to-I RNA editing of the MicroRNA 16-1 (MIR16-1).	.	34324489; 23974981	.
M6ACROT00097	REG00007	M6ATAR00536	RNA modification / A-to-I	EPIREG00002	EPITAR00050	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Interferon-inducible protein 4 (ADAR1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADAR mediated A-to-I RNA editing of the Rho GTPase activating protein 26 (ARHGAP26) transcript."	.	30781903; 33509238; 24067935	.
M6ACROT00098	REG00007	M6ATAR01294	RNA modification / A-to-I	EPIREG00016	EPITAR00051	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Double-stranded RNA-specific editase 1 (ADARB1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADARB1 mediated A-to-I RNA editing of the MicroRNA 122 (MIR122) transcript."	.	30781903; 24386085	.
M6ACROT00099	REG00008	M6ATAR01294	RNA modification / A-to-I	EPIREG00016	EPITAR00051	.	.	m6A	Direct	Inhibition	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	YTHDF2 recognizes the m6A methylation sites and prevents Double-stranded RNA-specific editase 1 (ADARB1) dependent A-to-I RNA editing of MicroRNA 122 (MIR122).	.	34324489; 24386085	.
M6ACROT00100	REG00007	M6ATAR01294	RNA modification / A-to-I	EPIREG00016	EPITAR00052	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Double-stranded RNA-specific editase 1 (ADARB1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADARB1 mediated A-to-I RNA editing of the MicroRNA 214 (MIR214) transcript."	.	30781903; 24386085	.
M6ACROT00101	REG00008	M6ATAR01294	RNA modification / A-to-I	EPIREG00016	EPITAR00052	.	.	m6A	Direct	Inhibition	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	YTHDF2 recognizes the m6A methylation sites and prevents Double-stranded RNA-specific editase 1 (ADARB1) dependent A-to-I RNA editing of MicroRNA 214 (MIR214).	.	34324489; 24386085	.
M6ACROT00102	REG00007	M6ATAR01294	RNA modification / A-to-I	EPIREG00016	EPITAR00053	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Double-stranded RNA-specific editase 1 (ADARB1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADARB1 mediated A-to-I RNA editing of the Oligophrenin 1 (OPHN1) transcript."	.	30781903; 24637888	.
M6ACROT00103	REG00008	M6ATAR01294	RNA modification / A-to-I	EPIREG00016	EPITAR00053	.	.	m6A	Direct	Inhibition	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	YTHDF2 recognizes the m6A methylation sites and prevents Double-stranded RNA-specific editase 1 (ADARB1) dependent A-to-I RNA editing of Oligophrenin 1 (OPHN1).	.	34324489; 24637888	.
M6ACROT00104	REG00007	M6ATAR01294	RNA modification / A-to-I	EPIREG00016	EPITAR00054	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Double-stranded RNA-specific editase 1 (ADARB1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADARB1 mediated A-to-I RNA editing of the MicroRNA 21 (MIR21) transcript."	.	30781903; 25582055; 29637273	.
M6ACROT00105	REG00008	M6ATAR01294	RNA modification / A-to-I	EPIREG00016	EPITAR00054	.	.	m6A	Direct	Inhibition	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	YTHDF2 recognizes the m6A methylation sites and prevents Double-stranded RNA-specific editase 1 (ADARB1) dependent A-to-I RNA editing of MicroRNA 21 (MIR21).	.	34324489; 25582055; 29637273	.
M6ACROT00106	REG00007	M6ATAR01294	RNA modification / A-to-I	EPIREG00016	EPITAR00055	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Double-stranded RNA-specific editase 1 (ADARB1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADARB1 mediated A-to-I RNA editing of the MicroRNA 221 (MIR221) transcript."	.	30781903; 25582055	.
M6ACROT00107	REG00008	M6ATAR01294	RNA modification / A-to-I	EPIREG00016	EPITAR00055	.	.	m6A	Direct	Inhibition	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	YTHDF2 recognizes the m6A methylation sites and prevents Double-stranded RNA-specific editase 1 (ADARB1) dependent A-to-I RNA editing of MicroRNA 221 (MIR221).	.	34324489; 25582055	.
M6ACROT00108	REG00007	M6ATAR01294	RNA modification / A-to-I	EPIREG00016	EPITAR00056	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Double-stranded RNA-specific editase 1 (ADARB1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADARB1 mediated A-to-I RNA editing of the MicroRNA 222 (MIR222) transcript."	.	30781903; 25582055	.
M6ACROT00109	REG00008	M6ATAR01294	RNA modification / A-to-I	EPIREG00016	EPITAR00056	.	.	m6A	Direct	Inhibition	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	YTHDF2 recognizes the m6A methylation sites and prevents Double-stranded RNA-specific editase 1 (ADARB1) dependent A-to-I RNA editing of MicroRNA 222 (MIR222).	.	34324489; 25582055	.
M6ACROT00110	REG00007	M6ATAR00536	RNA modification / A-to-I	EPIREG00002	EPITAR00057	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Interferon-inducible protein 4 (ADAR1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADAR mediated A-to-I RNA editing of the Prune homolog 2 with BCH domain (PRUNE2) transcript."	.	30781903; 33509238; 26080435	.
M6ACROT00111	REG00007	M6ATAR00536	RNA modification / A-to-I	EPIREG00002	EPITAR00056	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Interferon-inducible protein 4 (ADAR1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADAR mediated A-to-I RNA editing of the MicroRNA 222 (MIR222) transcript."	.	30781903; 33509238; 26338962	.
M6ACROT00112	REG00007	M6ATAR00536	RNA modification / A-to-I	EPIREG00002	EPITAR00058	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Interferon-inducible protein 4 (ADAR1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADAR mediated A-to-I RNA editing of the Aryl hydrocarbon receptor (AHR) transcript."	.	30781903; 33509238; 26601943	.
M6ACROT00113	REG00007	M6ATAR00536	RNA modification / A-to-I	EPIREG00002	EPITAR00059	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Interferon-inducible protein 4 (ADAR1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADAR mediated A-to-I RNA editing of the MicroRNA 381 (MIR381) transcript."	.	30781903; 33509238; 26640150	.
M6ACROT00114	REG00007	M6ATAR00536	RNA modification / A-to-I	EPIREG00002	EPITAR00060	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Interferon-inducible protein 4 (ADAR1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADAR mediated A-to-I RNA editing of the Inhibitor of nuclear factor kappa-B kinase subunit beta (IKBKB) transcript."	.	30781903; 33509238; 27362366	M6ADRUG0230
M6ACROT00115	REG00007	M6ATAR00536	RNA modification / A-to-I	EPIREG00002	EPITAR00061	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Interferon-inducible protein 4 (ADAR1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADAR mediated A-to-I RNA editing of the Actin, aortic smooth muscle (ACTA2) transcript."	.	30781903; 33509238; 27362366	.
M6ACROT00116	REG00007	M6ATAR00536	RNA modification / A-to-I	EPIREG00002	EPITAR00062	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Interferon-inducible protein 4 (ADAR1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADAR mediated A-to-I RNA editing of the Collagen alpha-1 (COL1A1) transcript."	.	30781903; 33509238; 27362366	.
M6ACROT00117	REG00007	M6ATAR00536	RNA modification / A-to-I	EPIREG00002	EPITAR00063	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Interferon-inducible protein 4 (ADAR1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADAR mediated A-to-I RNA editing of the Podocalyxin like (PODXL) transcript."	.	30781903; 33509238; 27373511	.
M6ACROT00118	REG00007	M6ATAR01294	RNA modification / A-to-I	EPIREG00016	EPITAR00063	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Double-stranded RNA-specific editase 1 (ADARB1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADARB1 mediated A-to-I RNA editing of the Podocalyxin like (PODXL) transcript."	.	30781903; 27373511	.
M6ACROT00119	REG00008	M6ATAR01294	RNA modification / A-to-I	EPIREG00016	EPITAR00063	.	.	m6A	Direct	Inhibition	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	YTHDF2 recognizes the m6A methylation sites and prevents Double-stranded RNA-specific editase 1 (ADARB1) dependent A-to-I RNA editing of Podocalyxin like (PODXL).	.	34324489; 27373511	.
M6ACROT00120	REG00007	M6ATAR00536	RNA modification / A-to-I	EPIREG00002	EPITAR00064	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Interferon-inducible protein 4 (ADAR1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADAR mediated A-to-I RNA editing of the Cathepsin S (CTSS) transcript."	.	30781903; 33509238; 27595325	M6ADRUG0231
M6ACROT00121	REG00007	M6ATAR01294	RNA modification / A-to-I	EPIREG00016	EPITAR00065	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Double-stranded RNA-specific editase 1 (ADARB1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADARB1 mediated A-to-I RNA editing of the Insulin-like growth factor-binding protein 7 (IGFBP7) transcript."	.	30781903; 28035363	.
M6ACROT00122	REG00008	M6ATAR01294	RNA modification / A-to-I	EPIREG00016	EPITAR00065	.	.	m6A	Direct	Inhibition	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	YTHDF2 recognizes the m6A methylation sites and prevents Double-stranded RNA-specific editase 1 (ADARB1) dependent A-to-I RNA editing of Insulin-like growth factor-binding protein 7 (IGFBP7).	.	34324489; 28035363	.
M6ACROT00123	REG00007	M6ATAR00536	RNA modification / A-to-I	EPIREG00002	EPITAR00066	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Interferon-inducible protein 4 (ADAR1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADAR mediated A-to-I RNA editing of the Dihydrofolate reductase (DHFR) transcript."	.	30781903; 33509238; 28188287	M6ADRUG0232
M6ACROT00124	REG00007	M6ATAR00536	RNA modification / A-to-I	EPIREG00002	EPITAR00067	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Interferon-inducible protein 4 (ADAR1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADAR mediated A-to-I RNA editing of the Signal transducer and activator of transcription 3 (STAT3) transcript."	.	30781903; 33509238; 28278381	M6ADRUG0233
M6ACROT00125	REG00007	M6ATAR00536	RNA modification / A-to-I	EPIREG00002	EPITAR00068	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Interferon-inducible protein 4 (ADAR1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADAR mediated A-to-I RNA editing of the Intercellular adhesion molecule 1 (ICAM1) transcript."	.	30781903; 33509238; 28527816	M6ADRUG0234
M6ACROT00126	REG00007	M6ATAR00536	RNA modification / A-to-I	EPIREG00002	EPITAR00069	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Interferon-inducible protein 4 (ADAR1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADAR mediated A-to-I RNA editing of the Vascular cell adhesion protein 1 (VCAM1) transcript."	.	30781903; 33509238; 28527816	M6ADRUG0235
M6ACROT00127	REG00007	M6ATAR00536	RNA modification / A-to-I	EPIREG00002	EPITAR00070	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Interferon-inducible protein 4 (ADAR1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADAR mediated A-to-I RNA editing of the E3 ubiquitin-protein ligase Mdm2 (Mdm2) transcript."	.	30781903; 33509238; 28542129; 30612940	M6ADRUG0236
M6ACROT00128	REG00007	M6ATAR00536	RNA modification / A-to-I	EPIREG00002	EPITAR00071	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Interferon-inducible protein 4 (ADAR1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADAR mediated A-to-I RNA editing of the X-linked inhibitor of apoptosis (XIAP) transcript."	.	30781903; 33509238; 28542129	M6ADRUG0237
M6ACROT00129	REG00007	M6ATAR00536	RNA modification / A-to-I	EPIREG00002	EPITAR00072	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Interferon-inducible protein 4 (ADAR1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADAR mediated A-to-I RNA editing of the G1/S-specific cyclin-D1 (CCND1) transcript."	.	30781903; 33509238; 28928239; 33750389	M6ADRUG0238
M6ACROT00130	REG00007	M6ATAR00536	RNA modification / A-to-I	EPIREG00002	EPITAR00073	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Interferon-inducible protein 4 (ADAR1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADAR mediated A-to-I RNA editing of the F11 receptor (F11R) transcript."	.	30781903; 33509238; 28928239	.
M6ACROT00131	REG00007	M6ATAR00536	RNA modification / A-to-I	EPIREG00002	EPITAR00074	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Interferon-inducible protein 4 (ADAR1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADAR mediated A-to-I RNA editing of the Protein tyrosine kinase 2 (PTK2) transcript."	.	30781903; 33509238; 28928239	M6ADRUG0160
M6ACROT00132	REG00007	M6ATAR00536	RNA modification / A-to-I	EPIREG00002	EPITAR00075	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Interferon-inducible protein 4 (ADAR1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADAR mediated A-to-I RNA editing of the Thiol methyltransferase 1A (TMT1A) transcript."	.	30781903; 33509238; 28985428	.
M6ACROT00133	REG00007	M6ATAR01294	RNA modification / A-to-I	EPIREG00016	EPITAR00075	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Double-stranded RNA-specific editase 1 (ADARB1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADARB1 mediated A-to-I RNA editing of the Thiol methyltransferase 1A (TMT1A) transcript."	.	30781903; 28985428	.
M6ACROT00134	REG00008	M6ATAR01294	RNA modification / A-to-I	EPIREG00016	EPITAR00075	.	.	m6A	Direct	Inhibition	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	YTHDF2 recognizes the m6A methylation sites and prevents Double-stranded RNA-specific editase 1 (ADARB1) dependent A-to-I RNA editing of Thiol methyltransferase 1A (TMT1A).	.	34324489; 28985428	.
M6ACROT00135	REG00007	M6ATAR00536	RNA modification / A-to-I	EPIREG00002	EPITAR00076	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Interferon-inducible protein 4 (ADAR1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADAR mediated A-to-I RNA editing of the Interferon induced with helicase C domain 1 (IFIH1) transcript."	.	30781903; 33509238; 29042669	.
M6ACROT00136	REG00007	M6ATAR00536	RNA modification / A-to-I	EPIREG00002	EPITAR00054	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Interferon-inducible protein 4 (ADAR1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADAR mediated A-to-I RNA editing of the MicroRNA 21 (MIR21) transcript."	.	30781903; 33509238; 29637273; 31315644	.
M6ACROT00137	REG00007	M6ATAR00536	RNA modification / A-to-I	EPIREG00002	EPITAR00077	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Interferon-inducible protein 4 (ADAR1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADAR mediated A-to-I RNA editing of the Pellino E3 ubiquitin protein ligase 1 (PELI1) transcript."	.	30781903; 33509238; 29637273	.
M6ACROT00138	REG00007	M6ATAR00536	RNA modification / A-to-I	EPIREG00002	EPITAR00078	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Interferon-inducible protein 4 (ADAR1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADAR mediated A-to-I RNA editing of the Protein sprouty homolog 2 (SPRY2) transcript."	.	30781903; 33509238; 29637273	.
M6ACROT00139	REG00007	M6ATAR01294	RNA modification / A-to-I	EPIREG00016	EPITAR00077	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Double-stranded RNA-specific editase 1 (ADARB1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADARB1 mediated A-to-I RNA editing of the Pellino E3 ubiquitin protein ligase 1 (PELI1) transcript."	.	30781903; 29637273	.
M6ACROT00140	REG00008	M6ATAR01294	RNA modification / A-to-I	EPIREG00016	EPITAR00077	.	.	m6A	Direct	Inhibition	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	YTHDF2 recognizes the m6A methylation sites and prevents Double-stranded RNA-specific editase 1 (ADARB1) dependent A-to-I RNA editing of Pellino E3 ubiquitin protein ligase 1 (PELI1).	.	34324489; 29637273	.
M6ACROT00141	REG00007	M6ATAR01294	RNA modification / A-to-I	EPIREG00016	EPITAR00078	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Double-stranded RNA-specific editase 1 (ADARB1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADARB1 mediated A-to-I RNA editing of the Protein sprouty homolog 2 (SPRY2) transcript."	.	30781903; 29637273	.
M6ACROT00142	REG00008	M6ATAR01294	RNA modification / A-to-I	EPIREG00016	EPITAR00078	.	.	m6A	Direct	Inhibition	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	YTHDF2 recognizes the m6A methylation sites and prevents Double-stranded RNA-specific editase 1 (ADARB1) dependent A-to-I RNA editing of Protein sprouty homolog 2 (SPRY2).	.	34324489; 29637273	.
M6ACROT00143	REG00007	M6ATAR00536	RNA modification / A-to-I	EPIREG00002	EPITAR00079	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Interferon-inducible protein 4 (ADAR1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADAR mediated A-to-I RNA editing of the Heterogeneous nuclear ribonucleoprotein L like (HNRNPLL) transcript."	.	30781903; 33509238; 29769310	.
M6ACROT00144	REG00007	M6ATAR01294	RNA modification / A-to-I	EPIREG00016	EPITAR00079	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Double-stranded RNA-specific editase 1 (ADARB1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADARB1 mediated A-to-I RNA editing of the Heterogeneous nuclear ribonucleoprotein L like (HNRNPLL) transcript."	.	30781903; 29769310	.
M6ACROT00145	REG00008	M6ATAR01294	RNA modification / A-to-I	EPIREG00016	EPITAR00079	.	.	m6A	Direct	Inhibition	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	YTHDF2 recognizes the m6A methylation sites and prevents Double-stranded RNA-specific editase 1 (ADARB1) dependent A-to-I RNA editing of Heterogeneous nuclear ribonucleoprotein L like (HNRNPLL).	.	34324489; 29769310	.
M6ACROT00146	REG00007	M6ATAR00536	RNA modification / A-to-I	EPIREG00002	EPITAR00080	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Interferon-inducible protein 4 (ADAR1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADAR mediated A-to-I RNA editing of the Paired box protein Pax-6 (PAX6) transcript."	.	30781903; 33509238; 29855470	.
M6ACROT00147	REG00007	M6ATAR01294	RNA modification / A-to-I	EPIREG00016	EPITAR00081	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Double-stranded RNA-specific editase 1 (ADARB1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADARB1 mediated A-to-I RNA editing of the microRNA 142 (MicroRNA 142 (MIR142)) transcript."	.	30781903; 29956457	.
M6ACROT00148	REG00008	M6ATAR01294	RNA modification / A-to-I	EPIREG00016	EPITAR00081	.	.	m6A	Direct	Inhibition	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	YTHDF2 recognizes the m6A methylation sites and prevents Double-stranded RNA-specific editase 1 (ADARB1) dependent A-to-I RNA editing of MicroRNA 142 (MIR142).	.	34324489; 29956457	.
M6ACROT00149	REG00007	M6ATAR00536	RNA modification / A-to-I	EPIREG00002	EPITAR00082	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Interferon-inducible protein 4 (ADAR1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADAR mediated A-to-I RNA editing of the Cyclin dependent kinase 13 (CDK13) transcript."	.	30781903; 33509238; 29996118	M6ADRUG0240
M6ACROT00150	REG00007	M6ATAR01294	RNA modification / A-to-I	EPIREG00016	EPITAR00015	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Double-stranded RNA-specific editase 1 (ADARB1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADARB1 mediated A-to-I RNA editing of the Protein SON transcript."	.	30781903; 30448461	.
M6ACROT00151	REG00008	M6ATAR01294	RNA modification / A-to-I	EPIREG00016	EPITAR00015	.	.	m6A	Direct	Inhibition	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	YTHDF2 recognizes the m6A methylation sites and prevents Double-stranded RNA-specific editase 1 (ADARB1) dependent A-to-I RNA editing of Protein SON.	.	34324489; 30448461	.
M6ACROT00152	REG00007	M6ATAR01294	RNA modification / A-to-I	EPIREG00016	EPITAR00083	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Double-stranded RNA-specific editase 1 (ADARB1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADARB1 mediated A-to-I RNA editing of the Glutamate ionotropic receptor kainate type subunit 2 (GRIK2) transcript."	.	30781903; 30559217	M6ADRUG0241
M6ACROT00153	REG00008	M6ATAR01294	RNA modification / A-to-I	EPIREG00016	EPITAR00083	.	.	m6A	Direct	Inhibition	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	YTHDF2 recognizes the m6A methylation sites and prevents Double-stranded RNA-specific editase 1 (ADARB1) dependent A-to-I RNA editing of Glutamate ionotropic receptor kainate type subunit 2 (GRIK2).	.	34324489; 30559217	M6ADRUG0241
M6ACROT00154	REG00007	M6ATAR00536	RNA modification / A-to-I	EPIREG00002	EPITAR00084	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Interferon-inducible protein 4 (ADAR1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADAR mediated A-to-I RNA editing of the MicroRNA 26a-1 (MIR26A1) transcript."	.	30781903; 33509238; 30612940	.
M6ACROT00155	REG00007	M6ATAR00536	RNA modification / A-to-I	EPIREG00002	EPITAR00085	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Interferon-inducible protein 4 (ADAR1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADAR mediated A-to-I RNA editing of the Cellular tumor antigen p53 (TP53/p53) transcript."	.	30781903; 33509238; 30612940	M6ADRUG0222
M6ACROT00156	REG00007	M6ATAR00536	RNA modification / A-to-I	EPIREG00002	EPITAR00086	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Interferon-inducible protein 4 (ADAR1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADAR mediated A-to-I RNA editing of the Integrin subunit alpha 2 (ITGA2) transcript."	.	30781903; 33509238; 30798327	M6ADRUG0242
M6ACROT00157	REG00007	M6ATAR00536	RNA modification / A-to-I	EPIREG00002	EPITAR00087	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Interferon-inducible protein 4 (ADAR1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADAR mediated A-to-I RNA editing of the HIF1A antisense RNA 2 (HIF1A-AS2) transcript."	.	30781903; 33509238; 30948460	.
M6ACROT00158	REG00007	M6ATAR00536	RNA modification / A-to-I	EPIREG00002	EPITAR00088	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Interferon-inducible protein 4 (ADAR1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADAR mediated A-to-I RNA editing of the Cytochrome P450 2B6 (CYP2B6) transcript."	.	30781903; 33509238; 30988053; 31270214	.
M6ACROT00159	REG00007	M6ATAR00536	RNA modification / A-to-I	EPIREG00002	EPITAR00089	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Interferon-inducible protein 4 (ADAR1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADAR mediated A-to-I RNA editing of the Cytochrome P450 2C8 (CYP2C8) transcript."	.	30781903; 33509238; 30988053	.
M6ACROT00160	REG00007	M6ATAR00536	RNA modification / A-to-I	EPIREG00002	EPITAR00090	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Interferon-inducible protein 4 (ADAR1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADAR mediated A-to-I RNA editing of the Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) transcript."	.	30781903; 33509238; 30988053; 31270214	M6ADRUG0243
M6ACROT00161	REG00007	M6ATAR00536	RNA modification / A-to-I	EPIREG00002	EPITAR00091	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Interferon-inducible protein 4 (ADAR1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADAR mediated A-to-I RNA editing of the Hepatocyte nuclear factor 4 alpha (HNF4A) transcript."	.	30781903; 33509238; 30988053	M6ADRUG0244
M6ACROT00162	REG00007	M6ATAR01294	RNA modification / A-to-I	EPIREG00016	EPITAR00088	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Double-stranded RNA-specific editase 1 (ADARB1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADARB1 mediated A-to-I RNA editing of the Cytochrome P450 2B6 (CYP2B6) transcript."	.	30781903; 30988053	.
M6ACROT00163	REG00008	M6ATAR01294	RNA modification / A-to-I	EPIREG00016	EPITAR00088	.	.	m6A	Direct	Inhibition	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	YTHDF2 recognizes the m6A methylation sites and prevents Double-stranded RNA-specific editase 1 (ADARB1) dependent A-to-I RNA editing of Cytochrome P450 2B6 (CYP2B6).	.	34324489; 30988053	.
M6ACROT00164	REG00007	M6ATAR01294	RNA modification / A-to-I	EPIREG00016	EPITAR00089	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Double-stranded RNA-specific editase 1 (ADARB1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADARB1 mediated A-to-I RNA editing of the Cytochrome P450 2C8 (CYP2C8) transcript."	.	30781903; 30988053	.
M6ACROT00165	REG00008	M6ATAR01294	RNA modification / A-to-I	EPIREG00016	EPITAR00089	.	.	m6A	Direct	Inhibition	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	YTHDF2 recognizes the m6A methylation sites and prevents Double-stranded RNA-specific editase 1 (ADARB1) dependent A-to-I RNA editing of Cytochrome P450 2C8 (CYP2C8).	.	34324489; 30988053	.
M6ACROT00166	REG00007	M6ATAR01294	RNA modification / A-to-I	EPIREG00016	EPITAR00091	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Double-stranded RNA-specific editase 1 (ADARB1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADARB1 mediated A-to-I RNA editing of the Hepatocyte nuclear factor 4 alpha (HNF4A) transcript."	.	30781903; 30988053	M6ADRUG0244
M6ACROT00167	REG00008	M6ATAR01294	RNA modification / A-to-I	EPIREG00016	EPITAR00091	.	.	m6A	Direct	Inhibition	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	YTHDF2 recognizes the m6A methylation sites and prevents Double-stranded RNA-specific editase 1 (ADARB1) dependent A-to-I RNA editing of Hepatocyte nuclear factor 4 alpha (HNF4A).	.	34324489; 30988053	M6ADRUG0244
M6ACROT00168	REG00007	M6ATAR00536	RNA modification / A-to-I	EPIREG00002	EPITAR00092	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Interferon-inducible protein 4 (ADAR1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADAR mediated A-to-I RNA editing of the CXADR cell adhesion molecule (CXADR) transcript."	.	30781903; 33509238; 31270214	.
M6ACROT00169	REG00007	M6ATAR01294	RNA modification / A-to-I	EPIREG00016	EPITAR00092	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Double-stranded RNA-specific editase 1 (ADARB1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADARB1 mediated A-to-I RNA editing of the CXADR cell adhesion molecule (CXADR) transcript."	.	30781903; 31270214	.
M6ACROT00170	REG00008	M6ATAR01294	RNA modification / A-to-I	EPIREG00016	EPITAR00092	.	.	m6A	Direct	Inhibition	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	YTHDF2 recognizes the m6A methylation sites and prevents Double-stranded RNA-specific editase 1 (ADARB1) dependent A-to-I RNA editing of CXADR cell adhesion molecule (CXADR).	.	34324489; 31270214	.
M6ACROT00171	REG00007	M6ATAR00536	RNA modification / A-to-I	EPIREG00002	EPITAR00093	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Interferon-inducible protein 4 (ADAR1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADAR mediated A-to-I RNA editing of the Endoribonuclease Dicer (DICER1) transcript."	.	30781903; 33509238; 31315644; 31959472	.
M6ACROT00172	REG00007	M6ATAR00536	RNA modification / A-to-I	EPIREG00002	EPITAR00094	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Interferon-inducible protein 4 (ADAR1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADAR mediated A-to-I RNA editing of the MicroRNA 155 (MIR155) transcript."	.	30781903; 33509238; 31315644	.
M6ACROT00173	REG00007	M6ATAR00536	RNA modification / A-to-I	EPIREG00002	EPITAR00095	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Interferon-inducible protein 4 (ADAR1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADAR mediated A-to-I RNA editing of the MicroRNA 181a-1 (MIR181A1) transcript."	.	30781903; 33509238; 31315644	.
M6ACROT00174	REG00007	M6ATAR00536	RNA modification / A-to-I	EPIREG00002	EPITAR00096	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Interferon-inducible protein 4 (ADAR1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADAR mediated A-to-I RNA editing of the hsa-mir-18a transcript."	.	30781903; 33509238; 31315644	.
M6ACROT00175	REG00007	M6ATAR00536	RNA modification / A-to-I	EPIREG00002	EPITAR00097	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Interferon-inducible protein 4 (ADAR1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADAR mediated A-to-I RNA editing of the MicroRNA 19a (MIR19A) transcript."	.	30781903; 33509238; 31315644	.
M6ACROT00176	REG00007	M6ATAR00536	RNA modification / A-to-I	EPIREG00002	EPITAR00098	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Interferon-inducible protein 4 (ADAR1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADAR mediated A-to-I RNA editing of the MicroRNA 210 (MIR210) transcript."	.	30781903; 33509238; 31315644	.
M6ACROT00177	REG00007	M6ATAR00536	RNA modification / A-to-I	EPIREG00002	EPITAR00099	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Interferon-inducible protein 4 (ADAR1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADAR mediated A-to-I RNA editing of the POU domain, class 5, transcription factor 1 (POU5F1) transcript."	.	30781903; 33509238; 31315644	.
M6ACROT00178	REG00007	M6ATAR00536	RNA modification / A-to-I	EPIREG00002	EPITAR00100	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Interferon-inducible protein 4 (ADAR1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADAR mediated A-to-I RNA editing of the Transcription factor SOX-2 (SOX2) transcript."	.	30781903; 33509238; 31315644	.
M6ACROT00179	REG00007	M6ATAR00536	RNA modification / A-to-I	EPIREG00002	EPITAR00101	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Interferon-inducible protein 4 (ADAR1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADAR mediated A-to-I RNA editing of the G1/S-specific cyclin-D2 (CCND2) transcript."	.	30781903; 33509238; 31572009	.
M6ACROT00180	REG00007	M6ATAR00536	RNA modification / A-to-I	EPIREG00002	EPITAR00102	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Interferon-inducible protein 4 (ADAR1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADAR mediated A-to-I RNA editing of the Catenin beta-1 (CTNNB1/Beta-catenin) transcript."	.	30781903; 33509238; 31572009	M6ADRUG0245
M6ACROT00181	REG00007	M6ATAR00536	RNA modification / A-to-I	EPIREG00002	EPITAR00022	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Interferon-inducible protein 4 (ADAR1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADAR mediated A-to-I RNA editing of the Myc proto-oncogene protein (MYC) transcript."	.	30781903; 33509238; 31572009; 32064158	M6ADRUG0220
M6ACROT00182	REG00007	M6ATAR00536	RNA modification / A-to-I	EPIREG00002	EPITAR00103	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Interferon-inducible protein 4 (ADAR1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADAR mediated A-to-I RNA editing of the Transcription factor 4 (TCF4) transcript."	.	30781903; 33509238; 31572009	.
M6ACROT00183	REG00007	M6ATAR00536	RNA modification / A-to-I	EPIREG00002	EPITAR00104	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Interferon-inducible protein 4 (ADAR1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADAR mediated A-to-I RNA editing of the MicroRNA 149 (MIR149) transcript."	.	30781903; 33509238; 31959472	.
M6ACROT00184	REG00007	M6ATAR01294	RNA modification / A-to-I	EPIREG00016	EPITAR00105	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Double-stranded RNA-specific editase 1 (ADARB1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADARB1 mediated A-to-I RNA editing of the Farnesyltransferase, CAAX box, subunit alpha (FNTA) transcript."	.	30781903; 32052578	.
M6ACROT00185	REG00008	M6ATAR01294	RNA modification / A-to-I	EPIREG00016	EPITAR00105	.	.	m6A	Direct	Inhibition	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"YTHDF2 recognizes the m6A methylation sites and prevents Double-stranded RNA-specific editase 1 (ADARB1) dependent A-to-I RNA editing of Farnesyltransferase, CAAX box, subunit alpha (FNTA)."	.	34324489; 32052578	.
M6ACROT00186	REG00007	M6ATAR00536	RNA modification / A-to-I	EPIREG00002	EPITAR00106	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Interferon-inducible protein 4 (ADAR1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADAR mediated A-to-I RNA editing of the MicroRNA 200b (MIR200B) transcript."	.	30781903; 33509238; 32157211	.
M6ACROT00187	REG00007	M6ATAR00536	RNA modification / A-to-I	EPIREG00002	EPITAR00107	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Interferon-inducible protein 4 (ADAR1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADAR mediated A-to-I RNA editing of the Interferon induced protein with tetratricopeptide repeats 3 (IFIT3) transcript."	.	30781903; 33509238; 32867271	.
M6ACROT00188	REG00007	M6ATAR00536	RNA modification / A-to-I	EPIREG00002	EPITAR00108	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Interferon-inducible protein 4 (ADAR1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADAR mediated A-to-I RNA editing of the Interferon regulatory factor 9 (IRF9) transcript."	.	30781903; 33509238; 32867271	.
M6ACROT00189	REG00007	M6ATAR00536	RNA modification / A-to-I	EPIREG00002	EPITAR00109	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Interferon-inducible protein 4 (ADAR1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADAR mediated A-to-I RNA editing of the MicroRNA 302a (MIR302A) transcript."	.	30781903; 33509238; 32867271	.
M6ACROT00190	REG00007	M6ATAR00536	RNA modification / A-to-I	EPIREG00002	EPITAR00110	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Interferon-inducible protein 4 (ADAR1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADAR mediated A-to-I RNA editing of the MicroRNA 302b (MIR302B) transcript."	.	30781903; 33509238; 32867271	.
M6ACROT00191	REG00007	M6ATAR00536	RNA modification / A-to-I	EPIREG00002	EPITAR00111	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Interferon-inducible protein 4 (ADAR1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADAR mediated A-to-I RNA editing of the MicroRNA 302c (MIR302C) transcript."	.	30781903; 33509238; 32867271	.
M6ACROT00192	REG00007	M6ATAR00536	RNA modification / A-to-I	EPIREG00002	EPITAR00112	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Interferon-inducible protein 4 (ADAR1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADAR mediated A-to-I RNA editing of the Transcription factor ISGF-3 components p91/p84 (STAT1) transcript."	.	30781903; 33509238; 32867271	M6ADRUG0246
M6ACROT00193	REG00007	M6ATAR00536	RNA modification / A-to-I	EPIREG00002	EPITAR00113	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Interferon-inducible protein 4 (ADAR1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADAR mediated A-to-I RNA editing of the Mitogen-activated protein kinase 1 (MAPK/ERK2/MAPK1) transcript."	.	30781903; 33509238; 33172486	M6ADRUG0247
M6ACROT00194	REG00007	M6ATAR00536	RNA modification / A-to-I	EPIREG00002	EPITAR00114	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Interferon-inducible protein 4 (ADAR1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADAR mediated A-to-I RNA editing of the APCDD1L divergent transcript (APCDD1L-DT) transcript."	.	30781903; 33509238; 33383047	.
M6ACROT00195	REG00007	M6ATAR00536	RNA modification / A-to-I	EPIREG00002	EPITAR00115	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Interferon-inducible protein 4 (ADAR1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADAR mediated A-to-I RNA editing of the H1-10 antisense RNA 1 (H1-10-AS1) transcript."	.	30781903; 33509238; 33383047	.
M6ACROT00196	REG00007	M6ATAR00536	RNA modification / A-to-I	EPIREG00002	EPITAR00116	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Interferon-inducible protein 4 (ADAR1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADAR mediated A-to-I RNA editing of the Long intergenic non-protein coding RNA 944 (LINC00944) transcript."	.	30781903; 33509238; 33383047	.
M6ACROT00197	REG00007	M6ATAR00536	RNA modification / A-to-I	EPIREG00002	EPITAR00117	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Interferon-inducible protein 4 (ADAR1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADAR mediated A-to-I RNA editing of the Long intergenic non-protein coding RNA 1003 (LINC01003) transcript."	.	30781903; 33509238; 33383047	.
M6ACROT00198	REG00007	M6ATAR00536	RNA modification / A-to-I	EPIREG00002	EPITAR00118	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Interferon-inducible protein 4 (ADAR1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADAR mediated A-to-I RNA editing of the Neurotrophic factor BDNF precursor form (BDNF) transcript."	.	30781903; 33509238; 33412228; 34568523	.
M6ACROT00199	REG00007	M6ATAR00536	RNA modification / A-to-I	EPIREG00002	EPITAR00119	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Interferon-inducible protein 4 (ADAR1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADAR mediated A-to-I RNA editing of the MicroRNA 432 (MIR432) transcript."	.	30781903; 33509238; 33412228	.
M6ACROT00200	REG00007	M6ATAR00536	RNA modification / A-to-I	EPIREG00002	EPITAR00120	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Interferon-inducible protein 4 (ADAR1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADAR mediated A-to-I RNA editing of the Nuclear receptor subfamily 1 group I member 2 (NR1I2) transcript."	.	30781903; 33509238; 33515843	M6ADRUG0248
M6ACROT00201	REG00007	M6ATAR01294	RNA modification / A-to-I	EPIREG00016	EPITAR00120	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Double-stranded RNA-specific editase 1 (ADARB1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADARB1 mediated A-to-I RNA editing of the Nuclear receptor subfamily 1 group I member 2 (NR1I2) transcript."	.	30781903; 33515843	M6ADRUG0248
M6ACROT00202	REG00008	M6ATAR01294	RNA modification / A-to-I	EPIREG00016	EPITAR00120	.	.	m6A	Direct	Inhibition	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	YTHDF2 recognizes the m6A methylation sites and prevents Double-stranded RNA-specific editase 1 (ADARB1) dependent A-to-I RNA editing of Nuclear receptor subfamily 1 group I member 2 (NR1I2).	.	34324489; 33515843	M6ADRUG0248
M6ACROT00203	REG00007	M6ATAR00536	RNA modification / A-to-I	EPIREG00002	EPITAR00121	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Interferon-inducible protein 4 (ADAR1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADAR mediated A-to-I RNA editing of the G1/S-specific cyclin-E1 (CCNE1) transcript."	.	30781903; 33509238; 33750389	M6ADRUG0249
M6ACROT00204	REG00007	M6ATAR00536	RNA modification / A-to-I	EPIREG00002	EPITAR00032	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Interferon-inducible protein 4 (ADAR1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADAR mediated A-to-I RNA editing of the Cyclin-dependent kinase 2 (CDK2) transcript."	.	30781903; 33509238; 33750389	M6ADRUG0226
M6ACROT00205	REG00007	M6ATAR00536	RNA modification / A-to-I	EPIREG00002	EPITAR00010	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Interferon-inducible protein 4 (ADAR1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADAR mediated A-to-I RNA editing of the Cyclin-dependent kinase 4 (CDK4) transcript."	.	30781903; 33509238; 33750389	M6ADRUG0224
M6ACROT00206	REG00007	M6ATAR00536	RNA modification / A-to-I	EPIREG00002	EPITAR00122	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Interferon-inducible protein 4 (ADAR1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADAR mediated A-to-I RNA editing of the Cyclin-dependent kinase 6 (CDK6) transcript."	.	30781903; 33509238; 33750389	M6ADRUG0224
M6ACROT00207	REG00007	M6ATAR00536	RNA modification / A-to-I	EPIREG00002	EPITAR00123	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Interferon-inducible protein 4 (ADAR1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADAR mediated A-to-I RNA editing of the Nuclear paraspeckle assembly transcript 1 (NEAT1) transcript."	.	30781903; 33509238; 34302813	.
M6ACROT00208	REG00007	M6ATAR00536	RNA modification / A-to-I	EPIREG00002	EPITAR00124	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Interferon-inducible protein 4 (ADAR1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADAR mediated A-to-I RNA editing of the C-X3-C motif chemokine ligand 1 (CX3CL1) transcript."	.	30781903; 33509238; 34319598	.
M6ACROT00209	REG00007	M6ATAR00536	RNA modification / A-to-I	EPIREG00002	EPITAR00125	.	.	m6A	Direct	Enhancement	A-to-I	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator	"METTL3 methylates Interferon-inducible protein 4 (ADAR1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADAR mediated A-to-I RNA editing of the hsa_circ_0000418 (Circ_CCT2) transcript."	.	30781903; 33509238; 34568523	.
M6ACROT00228	REG00012	M6ATAR00341	RNA modification / m5C	EPIREG00004	EPITAR00022	.	Up regulation	m6A	Direct	Enhancement	m5C	m6A modification directly impacts RNA modification through recruiting m6A regulator and targeting the shared RNA	IGF2BP1 recognizes the m6A methylation sites and promotes YBX1-dependent m5C RNA editing of Myc proto-oncogene protein (MYC) transcript.	.	19029303; 24926617; 29029484; 33763698; 34753494	M6ADRUG0220
M6ACROT00407	REG00025	M6ATAR00148	RNA modification / A-to-I	EPIREG00016	EPITAR00054	.	Down regulation	m6A	Indirect	Inhibition	A-to-I	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"YTHDF3 interacts with Growth arrest specific 5 (GAS5), increasing its m6A level and inhibiting its physical interaction with MicroRNA 21 (MIR21), which was regulated by ADARB1-mediated A-to-I modification. "	.	31619268; 25582055; 29637273; 31069831; 31572003; 31534503; 31319247	.
M6ACROT00408	REG00025	M6ATAR00148	RNA modification / A-to-I	EPIREG00002	EPITAR00054	.	Down regulation	m6A	Indirect	Inhibition	A-to-I	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"YTHDF3 interacts with Growth arrest specific 5 (GAS5), increasing its m6A level and inhibiting its physical interaction with MicroRNA 21 (MIR21), which was regulated by ADAR1-mediated A-to-I modification. "	.	31619268; 29637273; 31315644; 31069831; 31572003; 31534503; 31319247	.
M6ACROT00409	REG00012	M6ATAR00375	RNA modification / A-to-I	EPIREG00016	EPITAR00054	.	Up regulation	A-to-I	Indirect	Inhibition	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ADARB1 interacts with MicroRNA 21 (MIR21), increasing it's A-to-I level and inhibiting its physical interaction with Mutated in multiple advanced cancers 1 (PTEN), which was regulated by IGF2BP1-mediated m6A modification."	.	22279049; 25670861; 25582055; 29637273; 33332708; 33495842; 32412786; 31235554	.
M6ACROT00410	REG00012	M6ATAR00375	RNA modification / A-to-I	EPIREG00002	EPITAR00054	.	Up regulation	A-to-I	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ADAR1 interacts with MicroRNA 21 (MIR21), increasing it's A-to-I level and promoting its physical interaction with Mutated in multiple advanced cancers 1 (PTEN), which was regulated by IGF2BP1-mediated m6A modification."	.	22279049; 25670861; 29637273; 31315644; 33332708; 33495842; 32412786; 31235554	.
M6ACROT00411	REG00007	M6ATAR00375	RNA modification / A-to-I	EPIREG00016	EPITAR00054	.	Up regulation	A-to-I	Indirect	Inhibition	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ADARB1 interacts with MicroRNA 21 (MIR21), increasing it's A-to-I level and inhibiting its physical interaction with Mutated in multiple advanced cancers 1 (PTEN), which was regulated by METTL3-mediated m6A modification."	.	28920958; 32365051; 33749070; 25582055; 29637273; 33332708; 33495842; 32412786; 31235554	.
M6ACROT00412	REG00007	M6ATAR00375	RNA modification / A-to-I	EPIREG00002	EPITAR00054	.	Up regulation	A-to-I	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ADAR1 interacts with MicroRNA 21 (MIR21), increasing it's A-to-I level and promoting its physical interaction with Mutated in multiple advanced cancers 1 (PTEN), which was regulated by METTL3-mediated m6A modification."	.	28920958; 32365051; 33749070; 29637273; 31315644; 33332708; 33495842; 32412786; 31235554	.
M6ACROT00413	REG00006	M6ATAR00375	RNA modification / A-to-I	EPIREG00016	EPITAR00054	.	Up regulation	A-to-I	Indirect	Inhibition	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ADARB1 interacts with MicroRNA 21 (MIR21), increasing it's A-to-I level and inhibiting its physical interaction with Mutated in multiple advanced cancers 1 (PTEN), which was regulated by METTL14-mediated m6A modification."	.	33414476; 34476213; 25582055; 29637273; 33332708; 33495842; 32412786; 31235554	.
M6ACROT00414	REG00006	M6ATAR00375	RNA modification / A-to-I	EPIREG00002	EPITAR00054	.	Up regulation	A-to-I	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ADAR1 interacts with MicroRNA 21 (MIR21), increasing it's A-to-I level and promoting its physical interaction with Mutated in multiple advanced cancers 1 (PTEN), which was regulated by METTL14-mediated m6A modification."	.	33414476; 34476213; 29637273; 31315644; 33332708; 33495842; 32412786; 31235554	.
M6ACROT00415	REG00005	M6ATAR00375	RNA modification / A-to-I	EPIREG00016	EPITAR00054	.	Up regulation	A-to-I	Indirect	Inhibition	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ADARB1 interacts with MicroRNA 21 (MIR21), increasing it's A-to-I level and inhibiting its physical interaction with Mutated in multiple advanced cancers 1 (PTEN), which was regulated by ALKBH5-mediated m6A modification."	.	34438274; 25582055; 29637273; 33332708; 33495842; 32412786; 31235554	.
M6ACROT00416	REG00005	M6ATAR00375	RNA modification / A-to-I	EPIREG00002	EPITAR00054	.	Up regulation	A-to-I	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ADAR1 interacts with MicroRNA 21 (MIR21), increasing it's A-to-I level and promoting its physical interaction with Mutated in multiple advanced cancers 1 (PTEN), which was regulated by ALKBH5-mediated m6A modification."	.	34438274; 29637273; 31315644; 33332708; 33495842; 32412786; 31235554	.
M6ACROT00417	REG00005	M6ATAR00258	RNA modification / A-to-I	EPIREG00016	EPITAR00054	.	Up regulation	A-to-I	Indirect	Inhibition	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ADARB1 interacts with MicroRNA 21 (MIR21), increasing it's A-to-I level and inhibiting its physical interaction with Forkhead box protein M1 (FOXM1), which was regulated by ALKBH5-mediated m6A modification."	.	28344040; 31677788; 31974865; 33428593; 25582055; 29637273; 32782495	.
M6ACROT00418	REG00005	M6ATAR00258	RNA modification / A-to-I	EPIREG00002	EPITAR00054	.	Up regulation	A-to-I	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ADAR1 interacts with MicroRNA 21 (MIR21), increasing it's A-to-I level and promoting its physical interaction with Forkhead box protein M1 (FOXM1), which was regulated by ALKBH5-mediated m6A modification."	.	28344040; 31677788; 31974865; 33428593; 29637273; 31315644; 32782495	.
M6ACROT00419	REG00008	M6ATAR01535	RNA modification / A-to-I	EPIREG00016	EPITAR00054	.	Down regulation	A-to-I	Indirect	Inhibition	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ADARB1 interacts with MicroRNA 21 (MIR21), increasing it's A-to-I level and inhibiting its physical interaction with Runt-related transcription factor 1 (RUNX1), which was regulated by YTHDF2-mediated m6A modification."	.	30065315; 25582055; 29637273; 33061847	.
M6ACROT00420	REG00008	M6ATAR01535	RNA modification / A-to-I	EPIREG00002	EPITAR00054	.	Down regulation	A-to-I	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ADAR1 interacts with MicroRNA 21 (MIR21), increasing it's A-to-I level and promoting its physical interaction with Runt-related transcription factor 1 (RUNX1), which was regulated by YTHDF2-mediated m6A modification."	.	30065315; 29637273; 31315644; 33061847	.
M6ACROT00421	REG00007	M6ATAR00152	RNA modification / A-to-I	EPIREG00016	EPITAR00054	.	Up regulation	m6A	Indirect	Enhancement	A-to-I	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"METTL3 interacts with X inactive specific transcript (XIST), increasing its m6A level and promoting its physical interaction with MicroRNA 21 (MIR21), which was regulated by ADARB1-mediated A-to-I modification. "	.	30781903; 33748113; 25582055; 29637273; 31981974	.
M6ACROT00422	REG00007	M6ATAR00152	RNA modification / A-to-I	EPIREG00002	EPITAR00054	.	Up regulation	m6A	Indirect	Enhancement	A-to-I	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"METTL3 interacts with X inactive specific transcript (XIST), increasing its m6A level and promoting its physical interaction with MicroRNA 21 (MIR21), which was regulated by ADAR1-mediated A-to-I modification. "	.	30781903; 33748113; 29637273; 31315644; 31981974	.
M6ACROT00423	REG00008	M6ATAR00152	RNA modification / A-to-I	EPIREG00016	EPITAR00054	.	Down regulation	m6A	Indirect	Inhibition	A-to-I	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"YTHDF2 interacts with X inactive specific transcript (XIST), increasing its m6A level and inhibiting its physical interaction with MicroRNA 21 (MIR21), which was regulated by ADARB1-mediated A-to-I modification. "	.	32111213; 25582055; 29637273; 31981974	.
M6ACROT00424	REG00008	M6ATAR00152	RNA modification / A-to-I	EPIREG00002	EPITAR00054	.	Down regulation	m6A	Indirect	Inhibition	A-to-I	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"YTHDF2 interacts with X inactive specific transcript (XIST), increasing its m6A level and inhibiting its physical interaction with MicroRNA 21 (MIR21), which was regulated by ADAR1-mediated A-to-I modification. "	.	32111213; 29637273; 31315644; 31981974	.
M6ACROT00425	REG00009	M6ATAR00152	RNA modification / A-to-I	EPIREG00016	EPITAR00054	.	Up regulation	m6A	Indirect	Enhancement	A-to-I	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"WTAP interacts with X inactive specific transcript (XIST), increasing its m6A level and promoting its physical interaction with MicroRNA 21 (MIR21), which was regulated by ADARB1-mediated A-to-I modification. "	.	32111213; 25582055; 29637273; 31981974	.
M6ACROT00426	REG00009	M6ATAR00152	RNA modification / A-to-I	EPIREG00002	EPITAR00054	.	Up regulation	m6A	Indirect	Enhancement	A-to-I	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"WTAP interacts with X inactive specific transcript (XIST), increasing its m6A level and promoting its physical interaction with MicroRNA 21 (MIR21), which was regulated by ADAR1-mediated A-to-I modification. "	.	32111213; 29637273; 31315644; 31981974	.
M6ACROT00427	REG00006	M6ATAR00152	RNA modification / A-to-I	EPIREG00016	EPITAR00054	.	Down regulation	m6A	Indirect	Inhibition	A-to-I	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"METTL14 interacts with X inactive specific transcript (XIST), increasing its m6A level and inhibiting its physical interaction with MicroRNA 21 (MIR21), which was regulated by ADARB1-mediated A-to-I modification. "	.	32111213; 25582055; 29637273; 31981974	.
M6ACROT00428	REG00006	M6ATAR00152	RNA modification / A-to-I	EPIREG00002	EPITAR00054	.	Down regulation	m6A	Indirect	Inhibition	A-to-I	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"METTL14 interacts with X inactive specific transcript (XIST), increasing its m6A level and inhibiting its physical interaction with MicroRNA 21 (MIR21), which was regulated by ADAR1-mediated A-to-I modification. "	.	32111213; 29637273; 31315644; 31981974	.
M6ACROT00429	REG00007	M6ATAR00150	RNA modification / A-to-I	EPIREG00016	EPITAR00054	.	Down regulation	m6A	Indirect	Inhibition	A-to-I	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"METTL3 interacts with Maternally expressed 3 (MEG3), increasing its m6A level and inhibiting its physical interaction with MicroRNA 21 (MIR21), which was regulated by ADARB1-mediated A-to-I modification. "	.	34163177; 25582055; 29637273; 33332708; 33495842	.
M6ACROT00430	REG00007	M6ATAR00150	RNA modification / A-to-I	EPIREG00002	EPITAR00054	.	Down regulation	m6A	Indirect	Inhibition	A-to-I	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"METTL3 interacts with Maternally expressed 3 (MEG3), increasing its m6A level and inhibiting its physical interaction with MicroRNA 21 (MIR21), which was regulated by ADAR1-mediated A-to-I modification. "	.	34163177; 29637273; 31315644; 33332708; 33495842	.
M6ACROT00431	REG00014	M6ATAR00356	RNA modification / m7G	EPIREG00003	EPITAR00127	.	Down regulation	m7G	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"METTL1 interacts with MicroRNA 125a (MIR125A), increasing it's m7G level and promoting its physical interaction with Cellular tumor antigen p53 (TP53/p53), which was regulated by IGF2BP3-mediated m6A modification."	.	29212181; 31031083; 31819644	.
M6ACROT00432	REG00007	M6ATAR00356	RNA modification / m7G	EPIREG00003	EPITAR00127	.	Up regulation	m7G	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"METTL1 interacts with MicroRNA 125a (MIR125A), increasing it's m7G level and promoting its physical interaction with Cellular tumor antigen p53 (TP53/p53), which was regulated by METTL3-mediated m6A modification."	.	30578766; 31031083; 31819644	.
M6ACROT00433	REG00008	M6ATAR00356	RNA modification / m7G	EPIREG00003	EPITAR00127	.	Down regulation	m7G	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"METTL1 interacts with MicroRNA 125a (MIR125A), increasing it's m7G level and promoting its physical interaction with Cellular tumor antigen p53 (TP53/p53), which was regulated by YTHDF2-mediated m6A modification."	.	33726814; 31031083; 31819644	.
M6ACROT00434	REG00005	M6ATAR00140	RNA modification / m7G	EPIREG00003	EPITAR00127	.	Up regulation	m6A	Indirect	Enhancement	m7G	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"ALKBH5 interacts with Nuclear paraspeckle assembly transcript 1 (NEAT1), increasing its m6A level and promoting its physical interaction with MicroRNA 125a (MIR125A), which was regulated by METTL1-mediated m7G modification. "	.	31290116; 32913527; 31031083; 32388658; 30942442	.
M6ACROT00435	REG00006	M6ATAR00140	RNA modification / m7G	EPIREG00003	EPITAR00127	.	Down regulation	m6A	Indirect	Inhibition	m7G	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"METTL14 interacts with Nuclear paraspeckle assembly transcript 1 (NEAT1), increasing its m6A level and inhibiting its physical interaction with MicroRNA 125a (MIR125A), which was regulated by METTL1-mediated m7G modification. "	.	34813676; 31031083; 32388658; 30942442	.
M6ACROT00436	REG00014	M6ATAR00356	RNA modification / A-to-I	EPIREG00016	EPITAR00052	.	Down regulation	A-to-I	Indirect	Inhibition	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ADARB1 interacts with MicroRNA 214 (MIR214), increasing it's A-to-I level and inhibiting its physical interaction with Cellular tumor antigen p53 (TP53/p53), which was regulated by IGF2BP3-mediated m6A modification."	.	29212181; 24386085; 32827546	.
M6ACROT00437	REG00007	M6ATAR00356	RNA modification / A-to-I	EPIREG00016	EPITAR00052	.	Up regulation	A-to-I	Indirect	Inhibition	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ADARB1 interacts with MicroRNA 214 (MIR214), increasing it's A-to-I level and inhibiting its physical interaction with Cellular tumor antigen p53 (TP53/p53), which was regulated by METTL3-mediated m6A modification."	.	30578766; 24386085; 32827546	.
M6ACROT00438	REG00008	M6ATAR00356	RNA modification / A-to-I	EPIREG00016	EPITAR00052	.	Down regulation	A-to-I	Indirect	Inhibition	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ADARB1 interacts with MicroRNA 214 (MIR214), increasing it's A-to-I level and inhibiting its physical interaction with Cellular tumor antigen p53 (TP53/p53), which was regulated by YTHDF2-mediated m6A modification."	.	33726814; 24386085; 32827546	.
M6ACROT00439	REG00005	M6ATAR00140	RNA modification / A-to-I	EPIREG00016	EPITAR00052	.	Up regulation	m6A	Indirect	Enhancement	A-to-I	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"ALKBH5 interacts with Nuclear paraspeckle assembly transcript 1 (NEAT1), increasing its m6A level and promoting its physical interaction with MicroRNA 214 (MIR214), which was regulated by ADARB1-mediated A-to-I modification. "	.	31290116; 32913527; 24386085; 31731055	.
M6ACROT00440	REG00006	M6ATAR00140	RNA modification / A-to-I	EPIREG00016	EPITAR00052	.	Down regulation	m6A	Indirect	Inhibition	A-to-I	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"METTL14 interacts with Nuclear paraspeckle assembly transcript 1 (NEAT1), increasing its m6A level and inhibiting its physical interaction with MicroRNA 214 (MIR214), which was regulated by ADARB1-mediated A-to-I modification. "	.	34813676; 24386085; 31731055	.
M6ACROT00441	REG00007	M6ATAR00237	RNA modification / A-to-I	EPIREG00016	EPITAR00052	.	Up regulation	A-to-I	Indirect	Inhibition	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ADARB1 interacts with MicroRNA 214 (MIR214), increasing it's A-to-I level and inhibiting its physical interaction with Epidermal growth factor receptor (EGFR), which was regulated by METTL3-mediated m6A modification."	.	27117702; 27856248; 34530048; 24386085; 33635564	.
M6ACROT00442	REG00008	M6ATAR00237	RNA modification / A-to-I	EPIREG00016	EPITAR00052	.	Down regulation	A-to-I	Indirect	Inhibition	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ADARB1 interacts with MicroRNA 214 (MIR214), increasing it's A-to-I level and inhibiting its physical interaction with Epidermal growth factor receptor (EGFR), which was regulated by YTHDF2-mediated m6A modification."	.	30423408; 24386085; 33635564	.
M6ACROT00443	REG00025	M6ATAR00237	RNA modification / A-to-I	EPIREG00016	EPITAR00052	.	Up regulation	A-to-I	Indirect	Inhibition	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ADARB1 interacts with MicroRNA 214 (MIR214), increasing it's A-to-I level and inhibiting its physical interaction with Epidermal growth factor receptor (EGFR), which was regulated by YTHDF3-mediated m6A modification."	.	33125861; 24386085; 33635564	.
M6ACROT00444	REG00006	M6ATAR00237	RNA modification / A-to-I	EPIREG00016	EPITAR00052	.	Down regulation	A-to-I	Indirect	Inhibition	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ADARB1 interacts with MicroRNA 214 (MIR214), increasing it's A-to-I level and inhibiting its physical interaction with Epidermal growth factor receptor (EGFR), which was regulated by METTL14-mediated m6A modification."	.	33380825; 24386085; 33635564	.
M6ACROT00445	REG00024	M6ATAR00237	RNA modification / A-to-I	EPIREG00016	EPITAR00052	.	Up regulation	A-to-I	Indirect	Inhibition	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ADARB1 interacts with MicroRNA 214 (MIR214), increasing it's A-to-I level and inhibiting its physical interaction with Epidermal growth factor receptor (EGFR), which was regulated by YTHDF1-mediated m6A modification."	.	33638162; 24386085; 33635564	.
M6ACROT00446	REG00012	M6ATAR00375	RNA modification / A-to-I	EPIREG00016	EPITAR00052	.	Up regulation	A-to-I	Indirect	Inhibition	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ADARB1 interacts with MicroRNA 214 (MIR214), increasing it's A-to-I level and inhibiting its physical interaction with Mutated in multiple advanced cancers 1 (PTEN), which was regulated by IGF2BP1-mediated m6A modification."	.	22279049; 25670861; 24386085; 31704096; 31198405	.
M6ACROT00447	REG00007	M6ATAR00375	RNA modification / A-to-I	EPIREG00016	EPITAR00052	.	Up regulation	A-to-I	Indirect	Inhibition	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ADARB1 interacts with MicroRNA 214 (MIR214), increasing it's A-to-I level and inhibiting its physical interaction with Mutated in multiple advanced cancers 1 (PTEN), which was regulated by METTL3-mediated m6A modification."	.	28920958; 32365051; 33749070; 24386085; 31704096; 31198405	.
M6ACROT00448	REG00006	M6ATAR00375	RNA modification / A-to-I	EPIREG00016	EPITAR00052	.	Up regulation	A-to-I	Indirect	Inhibition	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ADARB1 interacts with MicroRNA 214 (MIR214), increasing it's A-to-I level and inhibiting its physical interaction with Mutated in multiple advanced cancers 1 (PTEN), which was regulated by METTL14-mediated m6A modification."	.	33414476; 34476213; 24386085; 31704096; 31198405	.
M6ACROT00449	REG00005	M6ATAR00375	RNA modification / A-to-I	EPIREG00016	EPITAR00052	.	Up regulation	A-to-I	Indirect	Inhibition	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ADARB1 interacts with MicroRNA 214 (MIR214), increasing it's A-to-I level and inhibiting its physical interaction with Mutated in multiple advanced cancers 1 (PTEN), which was regulated by ALKBH5-mediated m6A modification."	.	34438274; 24386085; 31704096; 31198405	.
M6ACROT00450	REG00005	M6ATAR00153	RNA modification / A-to-I	EPIREG00016	EPITAR00052	.	Up regulation	m6A	Indirect	Enhancement	A-to-I	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"ALKBH5 interacts with Pvt1 oncogene (PVT1), increasing its m6A level and promoting its physical interaction with MicroRNA 214 (MIR214), which was regulated by ADARB1-mediated A-to-I modification. "	.	32021563; 24386085; 32827544; 33527844	.
M6ACROT00451	REG00008	M6ATAR00153	RNA modification / A-to-I	EPIREG00016	EPITAR00052	.	Up regulation	m6A	Indirect	Enhancement	A-to-I	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"YTHDF2 interacts with Pvt1 oncogene (PVT1), increasing its m6A level and promoting its physical interaction with MicroRNA 214 (MIR214), which was regulated by ADARB1-mediated A-to-I modification. "	.	32021563; 24386085; 32827544; 33527844	.
M6ACROT00452	REG00024	M6ATAR00427	RNA modification / A-to-I	EPIREG00016	EPITAR00052	.	Up regulation	A-to-I	Indirect	Inhibition	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ADARB1 interacts with MicroRNA 214 (MIR214), increasing it's A-to-I level and inhibiting its physical interaction with Transferrin receptor protein 1 (TFRC), which was regulated by YTHDF1-mediated m6A modification."	.	33204330; 24386085; 32827547	.
M6ACROT00453	REG00014	M6ATAR00212	RNA modification / A-to-I	EPIREG00002	EPITAR00104	.	Up regulation	A-to-I	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ADAR1 interacts with MicroRNA 149 (MIR149), increasing it's A-to-I level and promoting its physical interaction with Cyclin-dependent kinase 6 (CDK6), which was regulated by IGF2BP3-mediated m6A modification."	.	26974154; 28399871; 31959472; 33880596	.
M6ACROT00454	REG00014	M6ATAR00212	RNA modification / m7G	EPIREG00003	EPITAR00104	.	Up regulation	m7G	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"METTL1 interacts with MicroRNA 149 (MIR149), increasing it's m7G level and promoting its physical interaction with Cyclin-dependent kinase 6 (CDK6), which was regulated by IGF2BP3-mediated m6A modification."	.	26974154; 28399871; 31866582; 33880596	.
M6ACROT00455	REG00002	M6ATAR00212	RNA modification / A-to-I	EPIREG00002	EPITAR00104	.	Up regulation	A-to-I	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ADAR1 interacts with MicroRNA 149 (MIR149), increasing it's A-to-I level and promoting its physical interaction with Cyclin-dependent kinase 6 (CDK6), which was regulated by ELAVL1-mediated m6A modification."	.	33219221; 31959472; 33880596	.
M6ACROT00456	REG00002	M6ATAR00212	RNA modification / m7G	EPIREG00003	EPITAR00104	.	Up regulation	m7G	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"METTL1 interacts with MicroRNA 149 (MIR149), increasing it's m7G level and promoting its physical interaction with Cyclin-dependent kinase 6 (CDK6), which was regulated by ELAVL1-mediated m6A modification."	.	33219221; 31866582; 33880596	.
M6ACROT00457	REG00009	M6ATAR00212	RNA modification / A-to-I	EPIREG00002	EPITAR00104	.	Up regulation	A-to-I	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ADAR1 interacts with MicroRNA 149 (MIR149), increasing it's A-to-I level and promoting its physical interaction with Cyclin-dependent kinase 6 (CDK6), which was regulated by WTAP-mediated m6A modification."	.	34595849; 31959472; 33880596	.
M6ACROT00458	REG00009	M6ATAR00212	RNA modification / m7G	EPIREG00003	EPITAR00104	.	Up regulation	m7G	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"METTL1 interacts with MicroRNA 149 (MIR149), increasing it's m7G level and promoting its physical interaction with Cyclin-dependent kinase 6 (CDK6), which was regulated by WTAP-mediated m6A modification."	.	34595849; 31866582; 33880596	.
M6ACROT00459	REG00004	M6ATAR00212	RNA modification / A-to-I	EPIREG00002	EPITAR00104	.	Down regulation	A-to-I	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ADAR1 interacts with MicroRNA 149 (MIR149), increasing it's A-to-I level and promoting its physical interaction with Cyclin-dependent kinase 6 (CDK6), which was regulated by HNRNPA2B1-mediated m6A modification."	.	34805798; 31959472; 33880596	.
M6ACROT00460	REG00004	M6ATAR00212	RNA modification / m7G	EPIREG00003	EPITAR00104	.	Down regulation	m7G	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"METTL1 interacts with MicroRNA 149 (MIR149), increasing it's m7G level and promoting its physical interaction with Cyclin-dependent kinase 6 (CDK6), which was regulated by HNRNPA2B1-mediated m6A modification."	.	34805798; 31866582; 33880596	.
M6ACROT00461	REG00007	M6ATAR01536	RNA modification / A-to-I	EPIREG00002	EPITAR00104	.	Up regulation	A-to-I	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ADAR1 interacts with MicroRNA 149 (MIR149), increasing it's A-to-I level and promoting its physical interaction with Macrophage colony-stimulating factor 1 (CSF1), which was regulated by METTL3-mediated m6A modification."	.	32869897; 31959472; 31911555	.
M6ACROT00462	REG00007	M6ATAR01536	RNA modification / m7G	EPIREG00003	EPITAR00104	.	Up regulation	m7G	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"METTL1 interacts with MicroRNA 149 (MIR149), increasing it's m7G level and promoting its physical interaction with Macrophage colony-stimulating factor 1 (CSF1), which was regulated by METTL3-mediated m6A modification."	.	32869897; 31866582; 31911555	.
M6ACROT00463	REG00005	M6ATAR00258	RNA modification / A-to-I	EPIREG00002	EPITAR00104	.	Up regulation	A-to-I	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ADAR1 interacts with MicroRNA 149 (MIR149), increasing it's A-to-I level and promoting its physical interaction with Forkhead box protein M1 (FOXM1), which was regulated by ALKBH5-mediated m6A modification."	.	28344040; 31677788; 31974865; 33428593; 31959472; 31597523	.
M6ACROT00464	REG00005	M6ATAR00258	RNA modification / m7G	EPIREG00003	EPITAR00104	.	Up regulation	m7G	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"METTL1 interacts with MicroRNA 149 (MIR149), increasing it's m7G level and promoting its physical interaction with Forkhead box protein M1 (FOXM1), which was regulated by ALKBH5-mediated m6A modification."	.	28344040; 31677788; 31974865; 33428593; 31866582; 31597523	.
M6ACROT00465	REG00002	M6ATAR00276	RNA modification / A-to-I	EPIREG00002	EPITAR00104	.	Up regulation	A-to-I	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ADAR1 interacts with MicroRNA 149 (MIR149), increasing it's A-to-I level and promoting its physical interaction with High mobility group protein HMGI-C (HMGA2), which was regulated by ELAVL1-mediated m6A modification."	.	30306128; 31959472; 33257506	.
M6ACROT00466	REG00002	M6ATAR00276	RNA modification / m7G	EPIREG00003	EPITAR00104	.	Up regulation	m7G	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"METTL1 interacts with MicroRNA 149 (MIR149), increasing it's m7G level and promoting its physical interaction with High mobility group protein HMGI-C (HMGA2), which was regulated by ELAVL1-mediated m6A modification."	.	30306128; 31866582; 33257506	.
M6ACROT00467	REG00006	M6ATAR00276	RNA modification / A-to-I	EPIREG00002	EPITAR00104	.	Up regulation	A-to-I	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ADAR1 interacts with MicroRNA 149 (MIR149), increasing it's A-to-I level and promoting its physical interaction with High mobility group protein HMGI-C (HMGA2), which was regulated by METTL14-mediated m6A modification."	.	30306128; 31959472; 33257506	.
M6ACROT00468	REG00006	M6ATAR00276	RNA modification / m7G	EPIREG00003	EPITAR00104	.	Up regulation	m7G	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"METTL1 interacts with MicroRNA 149 (MIR149), increasing it's m7G level and promoting its physical interaction with High mobility group protein HMGI-C (HMGA2), which was regulated by METTL14-mediated m6A modification."	.	30306128; 31866582; 33257506	.
M6ACROT00469	REG00007	M6ATAR01244	RNA modification / A-to-I	EPIREG00002	EPITAR00104	.	Up regulation	A-to-I	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ADAR1 interacts with MicroRNA 149 (MIR149), increasing it's A-to-I level and promoting its physical interaction with Stromal cell-derived factor 1 (CXCL12), which was regulated by METTL3-mediated m6A modification."	.	32148516; 31959472; 31206187	.
M6ACROT00470	REG00007	M6ATAR01244	RNA modification / m7G	EPIREG00003	EPITAR00104	.	Up regulation	m7G	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"METTL1 interacts with MicroRNA 149 (MIR149), increasing it's m7G level and promoting its physical interaction with Stromal cell-derived factor 1 (CXCL12), which was regulated by METTL3-mediated m6A modification."	.	32148516; 31866582; 31206187	.
M6ACROT00471	REG00006	M6ATAR00154	RNA modification / A-to-I	EPIREG00002	EPITAR00104	.	Up regulation	m6A	Indirect	Enhancement	A-to-I	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"METTL14 interacts with KCNQ1 opposite strand/antisense transcript 1 (KCNQ1OT1), increasing its m6A level and promoting its physical interaction with MicroRNA 149 (MIR149), which was regulated by ADAR1-mediated A-to-I modification. "	.	34648132; 31959472; 32753631	.
M6ACROT00472	REG00006	M6ATAR00154	RNA modification / m7G	EPIREG00003	EPITAR00104	.	Up regulation	m6A	Indirect	Enhancement	m7G	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"METTL14 interacts with KCNQ1 opposite strand/antisense transcript 1 (KCNQ1OT1), increasing its m6A level and promoting its physical interaction with MicroRNA 149 (MIR149), which was regulated by METTL1-mediated m7G modification. "	.	34648132; 31866582; 32753631	.
M6ACROT00473	REG00005	M6ATAR00140	RNA modification / A-to-I	EPIREG00002	EPITAR00095	.	Up regulation	m6A	Indirect	Enhancement	A-to-I	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"ALKBH5 interacts with Nuclear paraspeckle assembly transcript 1 (NEAT1), increasing its m6A level and promoting its physical interaction with MicroRNA 181a-1 (MIR181A1), which was regulated by ADAR1-mediated A-to-I modification. "	.	31290116; 32913527; 31315644; 31658244	.
M6ACROT00474	REG00006	M6ATAR00140	RNA modification / A-to-I	EPIREG00002	EPITAR00095	.	Down regulation	m6A	Indirect	Inhibition	A-to-I	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"METTL14 interacts with Nuclear paraspeckle assembly transcript 1 (NEAT1), increasing its m6A level and inhibiting its physical interaction with MicroRNA 181a-1 (MIR181A1), which was regulated by ADAR1-mediated A-to-I modification. "	.	34813676; 31315644; 31658244	.
M6ACROT00475	REG00005	M6ATAR00140	RNA modification / A-to-I	EPIREG00002	EPITAR00094	.	Up regulation	m6A	Indirect	Enhancement	A-to-I	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"ALKBH5 interacts with Nuclear paraspeckle assembly transcript 1 (NEAT1), increasing its m6A level and promoting its physical interaction with MicroRNA 155 (MIR155), which was regulated by ADAR1-mediated A-to-I modification. "	.	31290116; 32913527; 31315644; 30710754	.
M6ACROT00476	REG00006	M6ATAR00140	RNA modification / A-to-I	EPIREG00002	EPITAR00094	.	Down regulation	m6A	Indirect	Inhibition	A-to-I	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"METTL14 interacts with Nuclear paraspeckle assembly transcript 1 (NEAT1), increasing its m6A level and inhibiting its physical interaction with MicroRNA 155 (MIR155), which was regulated by ADAR1-mediated A-to-I modification. "	.	34813676; 31315644; 30710754	.
M6ACROT00477	REG00025	M6ATAR00148	RNA modification / A-to-I	EPIREG00002	EPITAR00094	.	Down regulation	m6A	Indirect	Inhibition	A-to-I	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"YTHDF3 interacts with Growth arrest specific 5 (GAS5), increasing its m6A level and inhibiting its physical interaction with MicroRNA 155 (MIR155), which was regulated by ADAR1-mediated A-to-I modification. "	.	31619268; 31315644; 34758804	.
M6ACROT00478	REG00002	M6ATAR00393	RNA modification / A-to-I	EPIREG00002	EPITAR00094	.	Up regulation	A-to-I	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ADAR1 interacts with MicroRNA 155 (MIR155), increasing it's A-to-I level and promoting its physical interaction with NAD-dependent protein deacetylase sirtuin-1 (SIRT1), which was regulated by ELAVL1-mediated m6A modification."	.	17317627; 31315644; 34294459; 31752013; 32243922	.
M6ACROT00479	REG00001	M6ATAR00393	RNA modification / A-to-I	EPIREG00002	EPITAR00094	.	Down regulation	A-to-I	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ADAR1 interacts with MicroRNA 155 (MIR155), increasing it's A-to-I level and promoting its physical interaction with NAD-dependent protein deacetylase sirtuin-1 (SIRT1), which was regulated by FTO-mediated m6A modification."	.	32154934; 31315644; 34294459; 31752013; 32243922	.
M6ACROT00480	REG00002	M6ATAR01171	RNA modification / A-to-I	EPIREG00002	EPITAR00094	.	Down regulation	A-to-I	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ADAR1 interacts with MicroRNA 155 (MIR155), increasing it's A-to-I level and promoting its physical interaction with Caspase-2 (CASP2), which was regulated by ELAVL1-mediated m6A modification."	.	28219770; 31315644; 33506901	.
M6ACROT00481	REG00007	M6ATAR00150	RNA modification / A-to-I	EPIREG00002	EPITAR00094	.	Down regulation	m6A	Indirect	Inhibition	A-to-I	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"METTL3 interacts with Maternally expressed 3 (MEG3), increasing its m6A level and inhibiting its physical interaction with MicroRNA 155 (MIR155), which was regulated by ADAR1-mediated A-to-I modification. "	.	34163177; 31315644; 32359033	.
M6ACROT00482	REG00006	M6ATAR00605	RNA modification / m6Am	EPIREG00018	EPITAR00132	.	Up regulation	m6Am	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"FTO interacts with hsa-mir-22, decreasing it's m6Am level and promoting its physical interaction with NACHT, LRR and PYD domains-containing protein 3 (NLRP3), which was regulated by METTL14-mediated m6A modification."	.	34412584; 25723394; 34296520	.
M6ACROT00483	REG00004	M6ATAR00399	RNA modification / m6Am	EPIREG00018	EPITAR00132	.	Down regulation	m6Am	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"FTO interacts with hsa-mir-22, decreasing it's m6Am level and promoting its physical interaction with Zinc finger protein SNAI1 (SNAI1), which was regulated by HNRNPA2B1-mediated m6A modification."	.	23495120; 25723394; 31081061	.
M6ACROT00484	REG00026	M6ATAR00399	RNA modification / m6Am	EPIREG00018	EPITAR00132	.	Down regulation	m6Am	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"FTO interacts with hsa-mir-22, decreasing it's m6Am level and promoting its physical interaction with Zinc finger protein SNAI1 (SNAI1), which was regulated by ZC3H13-mediated m6A modification."	.	30311220; 25723394; 31081061	.
M6ACROT00485	REG00008	M6ATAR00399	RNA modification / m6Am	EPIREG00018	EPITAR00132	.	Down regulation	m6Am	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"FTO interacts with hsa-mir-22, decreasing it's m6Am level and promoting its physical interaction with Zinc finger protein SNAI1 (SNAI1), which was regulated by YTHDF2-mediated m6A modification."	.	31061416; 25723394; 31081061	.
M6ACROT00486	REG00007	M6ATAR00399	RNA modification / m6Am	EPIREG00018	EPITAR00132	.	Up regulation	m6Am	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"FTO interacts with hsa-mir-22, decreasing it's m6Am level and promoting its physical interaction with Zinc finger protein SNAI1 (SNAI1), which was regulated by METTL3-mediated m6A modification."	.	32483411; 32512975; 33563300; 34457066; 25723394; 31081061	.
M6ACROT00487	REG00044	M6ATAR00399	RNA modification / m6Am	EPIREG00018	EPITAR00132	.	Up regulation	m6Am	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"FTO interacts with hsa-mir-22, decreasing it's m6Am level and promoting its physical interaction with Zinc finger protein SNAI1 (SNAI1), which was regulated by LRPPRC-mediated m6A modification."	.	34589577; 25723394; 31081061	.
M6ACROT00488	REG00007	M6ATAR00156	RNA modification / m6Am	EPIREG00018	EPITAR00132	.	Up regulation	m6A	Indirect	Enhancement	m6Am	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"METTL3 interacts with H19 imprinted maternally expressed transcript (H19), decreasing its m6A level and promoting its physical interaction with hsa-mir-22, which was regulated by FTO-mediated m6Am modification. "	.	30781903; 25723394; 31081061	.
M6ACROT00489	REG00013	M6ATAR00269	RNA modification / m6Am	EPIREG00018	EPITAR00132	.	Up regulation	m6Am	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"FTO interacts with hsa-mir-22, decreasing it's m6Am level and promoting its physical interaction with Glucose transporter type 1 (GLUT1), which was regulated by IGF2BP2-mediated m6A modification."	.	32245489; 25723394; 33517149	.
M6ACROT00490	REG00014	M6ATAR00269	RNA modification / m6Am	EPIREG00018	EPITAR00132	.	Up regulation	m6Am	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"FTO interacts with hsa-mir-22, decreasing it's m6Am level and promoting its physical interaction with Glucose transporter type 1 (GLUT1), which was regulated by IGF2BP3-mediated m6A modification."	.	32245489; 25723394; 33517149	.
M6ACROT00491	REG00007	M6ATAR00269	RNA modification / m6Am	EPIREG00018	EPITAR00132	.	Up regulation	m6Am	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"FTO interacts with hsa-mir-22, decreasing it's m6Am level and promoting its physical interaction with Glucose transporter type 1 (GLUT1), which was regulated by METTL3-mediated m6A modification."	.	32245489; 25723394; 33517149	.
M6ACROT00492	REG00044	M6ATAR00269	RNA modification / m6Am	EPIREG00018	EPITAR00132	.	Up regulation	m6Am	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"FTO interacts with hsa-mir-22, decreasing it's m6Am level and promoting its physical interaction with Glucose transporter type 1 (GLUT1), which was regulated by LRPPRC-mediated m6A modification."	.	34589577; 25723394; 33517149	.
M6ACROT00493	REG00004	M6ATAR00214	RNA modification / A-to-I	EPIREG00016	EPITAR00056	.	Down regulation	A-to-I	Indirect	Inhibition	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ADARB1 interacts with MicroRNA 222 (MIR222), increasing it's A-to-I level and inhibiting its physical interaction with Cyclin-dependent kinase inhibitor 1B (CDKN1B/p27), which was regulated by HNRNPA2B1-mediated m6A modification."	.	23495120; 25582055; 30718101	.
M6ACROT00494	REG00004	M6ATAR00214	RNA modification / A-to-I	EPIREG00002	EPITAR00056	.	Down regulation	A-to-I	Indirect	Inhibition	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ADAR1 interacts with MicroRNA 222 (MIR222), increasing it's A-to-I level and inhibiting its physical interaction with Cyclin-dependent kinase inhibitor 1B (CDKN1B/p27), which was regulated by HNRNPA2B1-mediated m6A modification."	.	23495120; 26338962; 30718101	.
M6ACROT00495	REG00014	M6ATAR00214	RNA modification / A-to-I	EPIREG00016	EPITAR00056	.	Down regulation	A-to-I	Indirect	Inhibition	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ADARB1 interacts with MicroRNA 222 (MIR222), increasing it's A-to-I level and inhibiting its physical interaction with Cyclin-dependent kinase inhibitor 1B (CDKN1B/p27), which was regulated by IGF2BP3-mediated m6A modification."	.	28399871; 25582055; 30718101	.
M6ACROT00496	REG00014	M6ATAR00214	RNA modification / A-to-I	EPIREG00002	EPITAR00056	.	Down regulation	A-to-I	Indirect	Inhibition	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ADAR1 interacts with MicroRNA 222 (MIR222), increasing it's A-to-I level and inhibiting its physical interaction with Cyclin-dependent kinase inhibitor 1B (CDKN1B/p27), which was regulated by IGF2BP3-mediated m6A modification."	.	28399871; 26338962; 30718101	.
M6ACROT00497	REG00006	M6ATAR00214	RNA modification / A-to-I	EPIREG00016	EPITAR00056	.	Up regulation	A-to-I	Indirect	Inhibition	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ADARB1 interacts with MicroRNA 222 (MIR222), increasing it's A-to-I level and inhibiting its physical interaction with Cyclin-dependent kinase inhibitor 1B (CDKN1B/p27), which was regulated by METTL14-mediated m6A modification."	.	30154548; 25582055; 30718101	.
M6ACROT00498	REG00006	M6ATAR00214	RNA modification / A-to-I	EPIREG00002	EPITAR00056	.	Up regulation	A-to-I	Indirect	Inhibition	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ADAR1 interacts with MicroRNA 222 (MIR222), increasing it's A-to-I level and inhibiting its physical interaction with Cyclin-dependent kinase inhibitor 1B (CDKN1B/p27), which was regulated by METTL14-mediated m6A modification."	.	30154548; 26338962; 30718101	.
M6ACROT00499	REG00007	M6ATAR00214	RNA modification / A-to-I	EPIREG00016	EPITAR00056	.	Up regulation	A-to-I	Indirect	Inhibition	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ADARB1 interacts with MicroRNA 222 (MIR222), increasing it's A-to-I level and inhibiting its physical interaction with Cyclin-dependent kinase inhibitor 1B (CDKN1B/p27), which was regulated by METTL3-mediated m6A modification."	.	30154548; 25582055; 30718101	.
M6ACROT00500	REG00007	M6ATAR00214	RNA modification / A-to-I	EPIREG00002	EPITAR00056	.	Up regulation	A-to-I	Indirect	Inhibition	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ADAR1 interacts with MicroRNA 222 (MIR222), increasing it's A-to-I level and inhibiting its physical interaction with Cyclin-dependent kinase inhibitor 1B (CDKN1B/p27), which was regulated by METTL3-mediated m6A modification."	.	30154548; 26338962; 30718101	.
M6ACROT00501	REG00009	M6ATAR00214	RNA modification / A-to-I	EPIREG00016	EPITAR00056	.	Down regulation	A-to-I	Indirect	Inhibition	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ADARB1 interacts with MicroRNA 222 (MIR222), increasing it's A-to-I level and inhibiting its physical interaction with Cyclin-dependent kinase inhibitor 1B (CDKN1B/p27), which was regulated by WTAP-mediated m6A modification."	.	31438961; 25582055; 30718101	.
M6ACROT00502	REG00009	M6ATAR00214	RNA modification / A-to-I	EPIREG00002	EPITAR00056	.	Down regulation	A-to-I	Indirect	Inhibition	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ADAR1 interacts with MicroRNA 222 (MIR222), increasing it's A-to-I level and inhibiting its physical interaction with Cyclin-dependent kinase inhibitor 1B (CDKN1B/p27), which was regulated by WTAP-mediated m6A modification."	.	31438961; 26338962; 30718101	.
M6ACROT00503	REG00002	M6ATAR00214	RNA modification / A-to-I	EPIREG00016	EPITAR00056	.	Up regulation	A-to-I	Indirect	Inhibition	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ADARB1 interacts with MicroRNA 222 (MIR222), increasing it's A-to-I level and inhibiting its physical interaction with Cyclin-dependent kinase inhibitor 1B (CDKN1B/p27), which was regulated by ELAVL1-mediated m6A modification."	.	31438961; 25582055; 30718101	.
M6ACROT00504	REG00002	M6ATAR00214	RNA modification / A-to-I	EPIREG00002	EPITAR00056	.	Up regulation	A-to-I	Indirect	Inhibition	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ADAR1 interacts with MicroRNA 222 (MIR222), increasing it's A-to-I level and inhibiting its physical interaction with Cyclin-dependent kinase inhibitor 1B (CDKN1B/p27), which was regulated by ELAVL1-mediated m6A modification."	.	31438961; 26338962; 30718101	.
M6ACROT00505	REG00002	M6ATAR00755	RNA modification / A-to-I	EPIREG00016	EPITAR00056	.	Up regulation	A-to-I	Indirect	Inhibition	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ADARB1 interacts with MicroRNA 222 (MIR222), increasing it's A-to-I level and inhibiting its physical interaction with Cyclic-AMP-dependent transcription factor ATF-3 (ATF3), which was regulated by ELAVL1-mediated m6A modification."	.	16109718; 25582055; 33794833	.
M6ACROT00506	REG00002	M6ATAR00755	RNA modification / A-to-I	EPIREG00002	EPITAR00056	.	Up regulation	A-to-I	Indirect	Inhibition	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ADAR1 interacts with MicroRNA 222 (MIR222), increasing it's A-to-I level and inhibiting its physical interaction with Cyclic-AMP-dependent transcription factor ATF-3 (ATF3), which was regulated by ELAVL1-mediated m6A modification."	.	16109718; 26338962; 33794833	.
M6ACROT00507	REG00008	M6ATAR00755	RNA modification / A-to-I	EPIREG00016	EPITAR00056	.	Down regulation	A-to-I	Indirect	Inhibition	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ADARB1 interacts with MicroRNA 222 (MIR222), increasing it's A-to-I level and inhibiting its physical interaction with Cyclic-AMP-dependent transcription factor ATF-3 (ATF3), which was regulated by YTHDF2-mediated m6A modification."	.	34213887; 25582055; 33794833	.
M6ACROT00508	REG00008	M6ATAR00755	RNA modification / A-to-I	EPIREG00002	EPITAR00056	.	Down regulation	A-to-I	Indirect	Inhibition	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ADAR1 interacts with MicroRNA 222 (MIR222), increasing it's A-to-I level and inhibiting its physical interaction with Cyclic-AMP-dependent transcription factor ATF-3 (ATF3), which was regulated by YTHDF2-mediated m6A modification."	.	34213887; 26338962; 33794833	.
M6ACROT00509	REG00025	M6ATAR00148	RNA modification / A-to-I	EPIREG00002	EPITAR00096	.	Down regulation	m6A	Indirect	Inhibition	A-to-I	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"YTHDF3 interacts with Growth arrest specific 5 (GAS5), increasing its m6A level and inhibiting its physical interaction with hsa-mir-18a, which was regulated by ADAR1-mediated A-to-I modification. "	.	31619268; 31315644; 32538667; 34698360	.
M6ACROT00510	REG00012	M6ATAR00375	RNA modification / A-to-I	EPIREG00002	EPITAR00096	.	Up regulation	A-to-I	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ADAR1 interacts with hsa-mir-18a, increasing it's A-to-I level and promoting its physical interaction with Mutated in multiple advanced cancers 1 (PTEN), which was regulated by IGF2BP1-mediated m6A modification."	.	22279049; 25670861; 31315644; 34194502	.
M6ACROT00511	REG00007	M6ATAR00375	RNA modification / A-to-I	EPIREG00002	EPITAR00096	.	Up regulation	A-to-I	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ADAR1 interacts with hsa-mir-18a, increasing it's A-to-I level and promoting its physical interaction with Mutated in multiple advanced cancers 1 (PTEN), which was regulated by METTL3-mediated m6A modification."	.	28920958; 32365051; 33749070; 31315644; 34194502	.
M6ACROT00512	REG00006	M6ATAR00375	RNA modification / A-to-I	EPIREG00002	EPITAR00096	.	Up regulation	A-to-I	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ADAR1 interacts with hsa-mir-18a, increasing it's A-to-I level and promoting its physical interaction with Mutated in multiple advanced cancers 1 (PTEN), which was regulated by METTL14-mediated m6A modification."	.	33414476; 34476213; 31315644; 34194502	.
M6ACROT00513	REG00005	M6ATAR00375	RNA modification / A-to-I	EPIREG00002	EPITAR00096	.	Up regulation	A-to-I	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ADAR1 interacts with hsa-mir-18a, increasing it's A-to-I level and promoting its physical interaction with Mutated in multiple advanced cancers 1 (PTEN), which was regulated by ALKBH5-mediated m6A modification."	.	34438274; 31315644; 34194502	.
M6ACROT00514	REG00008	M6ATAR01535	RNA modification / A-to-I	EPIREG00002	EPITAR00096	.	Down regulation	A-to-I	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ADAR1 interacts with hsa-mir-18a, increasing it's A-to-I level and promoting its physical interaction with Runt-related transcription factor 1 (RUNX1), which was regulated by YTHDF2-mediated m6A modification."	.	30065315; 31315644; 34077824	.
M6ACROT00515	REG00007	M6ATAR00150	RNA modification / A-to-I	EPIREG00002	EPITAR00096	.	Down regulation	m6A	Indirect	Inhibition	A-to-I	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"METTL3 interacts with Maternally expressed 3 (MEG3), increasing its m6A level and inhibiting its physical interaction with hsa-mir-18a, which was regulated by ADAR1-mediated A-to-I modification. "	.	34163177; 31315644; 32084370	.
M6ACROT00516	REG00025	M6ATAR00148	RNA modification / A-to-I	EPIREG00016	EPITAR00055	.	Down regulation	m6A	Indirect	Inhibition	A-to-I	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"YTHDF3 interacts with Growth arrest specific 5 (GAS5), increasing its m6A level and inhibiting its physical interaction with MicroRNA 221 (MIR221), which was regulated by ADARB1-mediated A-to-I modification. "	.	31619268; 25582055; 31631065; 31878844	.
M6ACROT00517	REG00002	M6ATAR00393	RNA modification / A-to-I	EPIREG00016	EPITAR00055	.	Up regulation	A-to-I	Indirect	Inhibition	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ADARB1 interacts with MicroRNA 221 (MIR221), increasing it's A-to-I level and inhibiting its physical interaction with NAD-dependent protein deacetylase sirtuin-1 (SIRT1), which was regulated by ELAVL1-mediated m6A modification."	.	17317627; 25582055; 32698791; 31631065; 34541816; 30926320	.
M6ACROT00518	REG00001	M6ATAR00393	RNA modification / A-to-I	EPIREG00016	EPITAR00055	.	Down regulation	A-to-I	Indirect	Inhibition	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ADARB1 interacts with MicroRNA 221 (MIR221), increasing it's A-to-I level and inhibiting its physical interaction with NAD-dependent protein deacetylase sirtuin-1 (SIRT1), which was regulated by FTO-mediated m6A modification."	.	32154934; 25582055; 32698791; 31631065; 34541816; 30926320	.
M6ACROT00519	REG00001	M6ATAR00937	RNA modification / A-to-I	EPIREG00016	EPITAR00055	.	Down regulation	A-to-I	Indirect	Inhibition	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ADARB1 interacts with MicroRNA 221 (MIR221), increasing it's A-to-I level and inhibiting its physical interaction with Protein c-Fos (FOS), which was regulated by FTO-mediated m6A modification."	.	34315853; 25582055; 31081202	.
M6ACROT00520	REG00008	M6ATAR00260	RNA modification / A-to-I	EPIREG00016	EPITAR00055	.	Down regulation	A-to-I	Indirect	Inhibition	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ADARB1 interacts with MicroRNA 221 (MIR221), increasing it's A-to-I level and inhibiting its physical interaction with Forkhead box protein O3 (FOXO3), which was regulated by YTHDF2-mediated m6A modification."	.	30065315; 25582055; 32629000	.
M6ACROT00521	REG00007	M6ATAR00260	RNA modification / A-to-I	EPIREG00016	EPITAR00055	.	Up regulation	A-to-I	Indirect	Inhibition	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ADARB1 interacts with MicroRNA 221 (MIR221), increasing it's A-to-I level and inhibiting its physical interaction with Forkhead box protein O3 (FOXO3), which was regulated by METTL3-mediated m6A modification."	.	32368828; 25582055; 32629000	.
M6ACROT00522	REG00005	M6ATAR00260	RNA modification / A-to-I	EPIREG00016	EPITAR00055	.	Up regulation	A-to-I	Indirect	Inhibition	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ADARB1 interacts with MicroRNA 221 (MIR221), increasing it's A-to-I level and inhibiting its physical interaction with Forkhead box protein O3 (FOXO3), which was regulated by ALKBH5-mediated m6A modification."	.	34786052; 25582055; 32629000	.
M6ACROT00523	REG00017	M6ATAR00274	RNA modification / A-to-I	EPIREG00016	EPITAR00081	.	Up regulation	A-to-I	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ADARB1 interacts with MicroRNA 142 (MIR142), increasing it's A-to-I level and promoting its physical interaction with Hypoxia-inducible factor 1-alpha (HIF-1-Alpha/HIF1A), which was regulated by METTL16-mediated m6A modification."	.	31940410; 29956457; 32222493	.
M6ACROT00524	REG00007	M6ATAR00274	RNA modification / A-to-I	EPIREG00016	EPITAR00081	.	Up regulation	A-to-I	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ADARB1 interacts with MicroRNA 142 (MIR142), increasing it's A-to-I level and promoting its physical interaction with Hypoxia-inducible factor 1-alpha (HIF-1-Alpha/HIF1A), which was regulated by METTL3-mediated m6A modification."	.	33305825; 29956457; 32222493	.
M6ACROT00525	REG00013	M6ATAR00274	RNA modification / A-to-I	EPIREG00016	EPITAR00081	.	Up regulation	A-to-I	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ADARB1 interacts with MicroRNA 142 (MIR142), increasing it's A-to-I level and promoting its physical interaction with Hypoxia-inducible factor 1-alpha (HIF-1-Alpha/HIF1A), which was regulated by IGF2BP2-mediated m6A modification."	.	34345216; 29956457; 32222493	.
M6ACROT00526	REG00014	M6ATAR00274	RNA modification / A-to-I	EPIREG00016	EPITAR00081	.	Up regulation	A-to-I	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ADARB1 interacts with MicroRNA 142 (MIR142), increasing it's A-to-I level and promoting its physical interaction with Hypoxia-inducible factor 1-alpha (HIF-1-Alpha/HIF1A), which was regulated by IGF2BP3-mediated m6A modification."	.	34621671; 29956457; 32222493	.
M6ACROT00527	REG00017	M6ATAR00274	RNA modification / m6Am	EPIREG00018	EPITAR00137	.	Up regulation	m6Am	Indirect	Inhibition	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"FTO interacts with MicroRNA 576 (MIR576), decreasing it's m6Am level and inhibiting its physical interaction with Hypoxia-inducible factor 1-alpha (HIF-1-Alpha/HIF1A), which was regulated by METTL16-mediated m6A modification."	.	31940410; 34725345; 31017266	.
M6ACROT00528	REG00007	M6ATAR00274	RNA modification / m6Am	EPIREG00018	EPITAR00137	.	Up regulation	m6Am	Indirect	Inhibition	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"FTO interacts with MicroRNA 576 (MIR576), decreasing it's m6Am level and inhibiting its physical interaction with Hypoxia-inducible factor 1-alpha (HIF-1-Alpha/HIF1A), which was regulated by METTL3-mediated m6A modification."	.	33305825; 34725345; 31017266	.
M6ACROT00529	REG00013	M6ATAR00274	RNA modification / m6Am	EPIREG00018	EPITAR00137	.	Up regulation	m6Am	Indirect	Inhibition	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"FTO interacts with MicroRNA 576 (MIR576), decreasing it's m6Am level and inhibiting its physical interaction with Hypoxia-inducible factor 1-alpha (HIF-1-Alpha/HIF1A), which was regulated by IGF2BP2-mediated m6A modification."	.	34345216; 34725345; 31017266	.
M6ACROT00530	REG00014	M6ATAR00274	RNA modification / m6Am	EPIREG00018	EPITAR00137	.	Up regulation	m6Am	Indirect	Inhibition	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"FTO interacts with MicroRNA 576 (MIR576), decreasing it's m6Am level and inhibiting its physical interaction with Hypoxia-inducible factor 1-alpha (HIF-1-Alpha/HIF1A), which was regulated by IGF2BP3-mediated m6A modification."	.	34621671; 34725345; 31017266	.
M6ACROT00531	REG00007	M6ATAR00156	RNA modification / A-to-I	EPIREG00002	EPITAR00097	.	Up regulation	m6A	Indirect	Enhancement	A-to-I	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"METTL3 interacts with H19 imprinted maternally expressed transcript (H19), increasing its m6A level and promoting its physical interaction with MicroRNA 19a (MIR19A), which was regulated by ADAR1-mediated A-to-I modification. "	.	30781903; 31315644; 31170091	.
M6ACROT00532	REG00015	M6ATAR00285	RNA modification / A-to-I	EPIREG00002	EPITAR00097	.	Down regulation	A-to-I	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ADAR1 interacts with MicroRNA 19a (MIR19A), increasing it's A-to-I level and promoting its physical interaction with DNA-binding protein inhibitor ID-2 (ID2), which was regulated by VIRMA-mediated m6A modification."	.	31118692; 31315644; 31170091	.
M6ACROT00533	REG00007	M6ATAR00141	RNA modification / A-to-I	EPIREG00002	EPITAR00084	.	Up regulation	m6A	Indirect	Enhancement	A-to-I	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"METTL3 interacts with Metastasis associated lung adenocarcinoma transcript 1 (MALAT1), increasing its m6A level and promoting its physical interaction with MicroRNA 26a-1 (MIR26A1), which was regulated by ADAR1-mediated A-to-I modification. "	.	30781903; 32203053; 33933553; 34419065; 30612940; 34278507	.
M6ACROT00534	REG00017	M6ATAR00141	RNA modification / A-to-I	EPIREG00002	EPITAR00084	.	Down regulation	m6A	Indirect	Inhibition	A-to-I	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"METTL16 interacts with Metastasis associated lung adenocarcinoma transcript 1 (MALAT1), increasing its m6A level and inhibiting its physical interaction with MicroRNA 26a-1 (MIR26A1), which was regulated by ADAR1-mediated A-to-I modification. "	.	31940410; 30612940; 34278507	.
M6ACROT00535	REG00005	M6ATAR00141	RNA modification / A-to-I	EPIREG00002	EPITAR00084	.	Up regulation	m6A	Indirect	Enhancement	A-to-I	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"ALKBH5 interacts with Metastasis associated lung adenocarcinoma transcript 1 (MALAT1), increasing its m6A level and promoting its physical interaction with MicroRNA 26a-1 (MIR26A1), which was regulated by ADAR1-mediated A-to-I modification. "	.	32656611; 30612940; 34278507	.
M6ACROT00536	REG00001	M6ATAR00141	RNA modification / A-to-I	EPIREG00002	EPITAR00084	.	Down regulation	m6A	Indirect	Inhibition	A-to-I	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"FTO interacts with Metastasis associated lung adenocarcinoma transcript 1 (MALAT1), increasing its m6A level and inhibiting its physical interaction with MicroRNA 26a-1 (MIR26A1), which was regulated by ADAR1-mediated A-to-I modification. "	.	33634966; 34499008; 30612940; 34278507	.
M6ACROT00537	REG00012	M6ATAR01124	RNA modification / A-to-I	EPIREG00002	EPITAR00119	.	Down regulation	A-to-I	Indirect	Inhibition	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ADAR1 interacts with MicroRNA 432 (MIR432), increasing it's A-to-I level and inhibiting its physical interaction with Insulin-like growth factor 2 (IGF2), which was regulated by IGF2BP1-mediated m6A modification."	.	22151897; 22279049; 30503558; 33412228; 31894251	.
M6ACROT00538	REG00014	M6ATAR01124	RNA modification / A-to-I	EPIREG00002	EPITAR00119	.	Up regulation	A-to-I	Indirect	Inhibition	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ADAR1 interacts with MicroRNA 432 (MIR432), increasing it's A-to-I level and inhibiting its physical interaction with Insulin-like growth factor 2 (IGF2), which was regulated by IGF2BP3-mediated m6A modification."	.	24457969; 28193878; 33412228; 31894251	.
M6ACROT00539	REG00013	M6ATAR01124	RNA modification / A-to-I	EPIREG00002	EPITAR00119	.	Up regulation	A-to-I	Indirect	Inhibition	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ADAR1 interacts with MicroRNA 432 (MIR432), increasing it's A-to-I level and inhibiting its physical interaction with Insulin-like growth factor 2 (IGF2), which was regulated by IGF2BP2-mediated m6A modification."	.	27153315; 33412228; 31894251	.
M6ACROT00540	REG00007	M6ATAR00261	RNA modification / A-to-I	EPIREG00002	EPITAR00106	.	Up regulation	A-to-I	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ADAR1 interacts with MicroRNA 200b (MIR200B), increasing it's A-to-I level and promoting its physical interaction with Fascin (FSCN1), which was regulated by METTL3-mediated m6A modification."	.	29476152; 32157211; 32220622	.
M6ACROT00541	REG00007	M6ATAR00261	RNA modification / m5C	EPIREG00004	EPITAR00106	.	Up regulation	m5C	Indirect	Inhibition	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"YBX1 interacts with MicroRNA 200b (MIR200B), reading its m5C sites and inhibiting its physical interaction with Fascin (FSCN1), which was regulated by METTL3-mediated m6A modification."	.	29476152; 34110104; 32220622	.
M6ACROT00542	REG00006	M6ATAR00261	RNA modification / A-to-I	EPIREG00002	EPITAR00106	.	Up regulation	A-to-I	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ADAR1 interacts with MicroRNA 200b (MIR200B), increasing it's A-to-I level and promoting its physical interaction with Fascin (FSCN1), which was regulated by METTL14-mediated m6A modification."	.	29476152; 32157211; 32220622	.
M6ACROT00543	REG00006	M6ATAR00261	RNA modification / m5C	EPIREG00004	EPITAR00106	.	Up regulation	m5C	Indirect	Inhibition	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"YBX1 interacts with MicroRNA 200b (MIR200B), reading its m5C sites and inhibiting its physical interaction with Fascin (FSCN1), which was regulated by METTL14-mediated m6A modification."	.	29476152; 34110104; 32220622	.
M6ACROT00544	REG00012	M6ATAR00261	RNA modification / A-to-I	EPIREG00002	EPITAR00106	.	Up regulation	A-to-I	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ADAR1 interacts with MicroRNA 200b (MIR200B), increasing it's A-to-I level and promoting its physical interaction with Fascin (FSCN1), which was regulated by IGF2BP1-mediated m6A modification."	.	29476152; 33853613; 32157211; 32220622	.
M6ACROT00545	REG00012	M6ATAR00261	RNA modification / m5C	EPIREG00004	EPITAR00106	.	Up regulation	m5C	Indirect	Inhibition	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"YBX1 interacts with MicroRNA 200b (MIR200B), reading its m5C sites and inhibiting its physical interaction with Fascin (FSCN1), which was regulated by IGF2BP1-mediated m6A modification."	.	29476152; 33853613; 34110104; 32220622	.
M6ACROT00546	REG00013	M6ATAR00261	RNA modification / A-to-I	EPIREG00002	EPITAR00106	.	Up regulation	A-to-I	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ADAR1 interacts with MicroRNA 200b (MIR200B), increasing it's A-to-I level and promoting its physical interaction with Fascin (FSCN1), which was regulated by IGF2BP2-mediated m6A modification."	.	29476152; 32157211; 32220622	.
M6ACROT00547	REG00013	M6ATAR00261	RNA modification / m5C	EPIREG00004	EPITAR00106	.	Up regulation	m5C	Indirect	Inhibition	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"YBX1 interacts with MicroRNA 200b (MIR200B), reading its m5C sites and inhibiting its physical interaction with Fascin (FSCN1), which was regulated by IGF2BP2-mediated m6A modification."	.	29476152; 34110104; 32220622	.
M6ACROT00548	REG00014	M6ATAR00261	RNA modification / A-to-I	EPIREG00002	EPITAR00106	.	Up regulation	A-to-I	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ADAR1 interacts with MicroRNA 200b (MIR200B), increasing it's A-to-I level and promoting its physical interaction with Fascin (FSCN1), which was regulated by IGF2BP3-mediated m6A modification."	.	29476152; 32157211; 32220622	.
M6ACROT00549	REG00014	M6ATAR00261	RNA modification / m5C	EPIREG00004	EPITAR00106	.	Up regulation	m5C	Indirect	Inhibition	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"YBX1 interacts with MicroRNA 200b (MIR200B), reading its m5C sites and inhibiting its physical interaction with Fascin (FSCN1), which was regulated by IGF2BP3-mediated m6A modification."	.	29476152; 34110104; 32220622	.
M6ACROT00550	REG00008	M6ATAR01537	RNA modification / A-to-I	EPIREG00002	EPITAR00098	.	Down regulation	A-to-I	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ADAR1 interacts with MicroRNA 210 (MIR210), increasing it's A-to-I level and promoting its physical interaction with Mothers against decapentaplegic homolog 4 (SMAD4), which was regulated by YTHDF2-mediated m6A modification."	.	30065315; 31315644; 32155285	.
M6ACROT00551	REG00002	M6ATAR01231	RNA modification / m5C	EPIREG00004	EPITAR00143	.	Up regulation	m6A	Indirect	Enhancement	m5C	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"ELAVL1 interacts with ZEB1 antisense RNA 1 (ZEB1-AS1), reading its m6A level and promoting its physical interaction with MicroRNA 205 (MIR205), which was regulated by YBX1-mediated m5C modification. "	.	31922280; 34110104; 32190742	.
M6ACROT00552	REG00013	M6ATAR01538	RNA modification / A-to-I	EPIREG00016	EPITAR00051	.	Up regulation	A-to-I	Indirect	Inhibition	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ADARB1 interacts with MicroRNA 122 (MIR122), increasing it's A-to-I level and inhibiting its physical interaction with Transcription factor SOX-6 (SOX6), which was regulated by IGF2BP2-mediated m6A modification."	.	34347395; 24386085; 31609809	.
M6ACROT00553	REG00007	M6ATAR01538	RNA modification / A-to-I	EPIREG00016	EPITAR00051	.	Up regulation	A-to-I	Indirect	Inhibition	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ADARB1 interacts with MicroRNA 122 (MIR122), increasing it's A-to-I level and inhibiting its physical interaction with Transcription factor SOX-6 (SOX6), which was regulated by METTL3-mediated m6A modification."	.	34347395; 24386085; 31609809	.
M6ACROT00554	REG00006	M6ATAR01538	RNA modification / A-to-I	EPIREG00016	EPITAR00051	.	Up regulation	A-to-I	Indirect	Inhibition	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ADARB1 interacts with MicroRNA 122 (MIR122), increasing it's A-to-I level and inhibiting its physical interaction with Transcription factor SOX-6 (SOX6), which was regulated by METTL14-mediated m6A modification."	.	34347395; 24386085; 31609809	.
M6ACROT00555	REG00008	M6ATAR00260	RNA modification / m5C	EPIREG00004	EPITAR00145	.	Down regulation	m5C	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"YBX1 interacts with Growth arrest specific 5 (GAS5), reading its m5C sites and promoting its physical interaction with Forkhead box protein O3 (FOXO3), which was regulated by YTHDF2-mediated m6A modification."	.	30065315; 25959498; 31534503; 34529353	.
M6ACROT00556	REG00007	M6ATAR00260	RNA modification / m5C	EPIREG00004	EPITAR00145	.	Up regulation	m5C	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"YBX1 interacts with Growth arrest specific 5 (GAS5), reading its m5C sites and promoting its physical interaction with Forkhead box protein O3 (FOXO3), which was regulated by METTL3-mediated m6A modification."	.	32368828; 25959498; 31534503; 34529353	.
M6ACROT00557	REG00005	M6ATAR00260	RNA modification / m5C	EPIREG00004	EPITAR00145	.	Up regulation	m5C	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"YBX1 interacts with Growth arrest specific 5 (GAS5), reading its m5C sites and promoting its physical interaction with Forkhead box protein O3 (FOXO3), which was regulated by ALKBH5-mediated m6A modification."	.	34786052; 25959498; 31534503; 34529353	.
M6ACROT00558	REG00044	M6ATAR00224	RNA modification / A-to-I	EPIREG00002	EPITAR00100	.	Up regulation	m6A	Indirect	Enhancement	A-to-I	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"LRPPRC interacts with Differentiation antagonizing non-protein coding RNA (DANCR), increasing its m6A level and promoting its physical interaction with Transcription factor SOX-2 (SOX2), which was regulated by ADAR1-mediated A-to-I modification. "	.	31315644; 30660488; 32971057	.
M6ACROT00559	REG00013	M6ATAR00224	RNA modification / A-to-I	EPIREG00002	EPITAR00100	.	Up regulation	m6A	Indirect	Enhancement	A-to-I	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"IGF2BP2 interacts with Differentiation antagonizing non-protein coding RNA (DANCR), increasing its m6A level and promoting its physical interaction with Transcription factor SOX-2 (SOX2), which was regulated by ADAR1-mediated A-to-I modification. "	.	31315644; 31804607; 32971057	.
M6ACROT00560	REG00044	M6ATAR00224	RNA modification / m6Am	EPIREG00018	EPITAR00100	.	Up regulation	m6A	Indirect	Enhancement	m6Am	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"LRPPRC interacts with Differentiation antagonizing non-protein coding RNA (DANCR), decreasing its m6A level and promoting its physical interaction with Transcription factor SOX-2 (SOX2), which was regulated by FTO-mediated m6Am modification. "	.	33783988; 30660488; 32971057	.
M6ACROT00561	REG00013	M6ATAR00224	RNA modification / m6Am	EPIREG00018	EPITAR00100	.	Up regulation	m6A	Indirect	Enhancement	m6Am	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"IGF2BP2 interacts with Differentiation antagonizing non-protein coding RNA (DANCR), decreasing its m6A level and promoting its physical interaction with Transcription factor SOX-2 (SOX2), which was regulated by FTO-mediated m6Am modification. "	.	33783988; 31804607; 32971057	.
M6ACROT00562	REG00044	M6ATAR00224	RNA modification / m7G	EPIREG00003	EPITAR00100	.	Up regulation	m6A	Indirect	Enhancement	m7G	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"LRPPRC interacts with Differentiation antagonizing non-protein coding RNA (DANCR), increasing its m6A level and promoting its physical interaction with Transcription factor SOX-2 (SOX2), which was regulated by METTL1-mediated m7G modification. "	.	32698871; 30660488; 32971057	.
M6ACROT00563	REG00013	M6ATAR00224	RNA modification / m7G	EPIREG00003	EPITAR00100	.	Up regulation	m6A	Indirect	Enhancement	m7G	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"IGF2BP2 interacts with Differentiation antagonizing non-protein coding RNA (DANCR), increasing its m6A level and promoting its physical interaction with Transcription factor SOX-2 (SOX2), which was regulated by METTL1-mediated m7G modification. "	.	32698871; 31804607; 32971057	.
M6ACROT00564	REG00025	M6ATAR00148	RNA modification / m5C	EPIREG00001	EPITAR00146	.	Down regulation	m6A	Indirect	Inhibition	m5C	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"YTHDF3 interacts with Growth arrest specific 5 (GAS5), increasing its m6A level and inhibiting its physical interaction with Cyclin-dependent kinase inhibitor 1C (CDKN1C), which was regulated by NSUN2-mediated m5C modification. "	.	32332707; 31619268; 32308561	.
M6ACROT00566	REG00007	M6ATAR00623	RNA modification / A-to-I	EPIREG00002	EPITAR00067	.	Down regulation	m6A	Indirect	Inhibition	A-to-I	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"METTL3 interacts with pri-miR-143, increasing its m6A level and inhibiting its physical interaction with Signal transducer and activator of transcription 3 (STAT3), which was regulated by ADAR1-mediated A-to-I modification. "	.	28278381; 31823788; 34428587; 33190168	.
M6ACROT00567	REG00015	M6ATAR00623	RNA modification / A-to-I	EPIREG00002	EPITAR00067	.	Up regulation	m6A	Indirect	Enhancement	A-to-I	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"VIRMA interacts with pri-miR-143, increasing its m6A level and promoting its physical interaction with Signal transducer and activator of transcription 3 (STAT3), which was regulated by ADAR1-mediated A-to-I modification. "	.	28278381; 34490238; 33190168	.
M6ACROT00568	REG00005	M6ATAR00623	RNA modification / A-to-I	EPIREG00002	EPITAR00067	.	Down regulation	m6A	Indirect	Inhibition	A-to-I	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"ALKBH5 interacts with pri-miR-143, increasing its m6A level and inhibiting its physical interaction with Signal transducer and activator of transcription 3 (STAT3), which was regulated by ADAR1-mediated A-to-I modification. "	.	28278381; 34490238; 33190168	.
M6ACROT00569	REG00007	M6ATAR00623	RNA modification / m6Am	EPIREG00018	EPITAR00067	.	Down regulation	m6A	Indirect	Inhibition	m6Am	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"METTL3 interacts with pri-miR-143, decreasing its m6A level and inhibiting its physical interaction with Signal transducer and activator of transcription 3 (STAT3), which was regulated by FTO-mediated m6Am modification. "	.	24410832; 34076564; 34537236; 31823788; 34428587; 33190168	.
M6ACROT00570	REG00015	M6ATAR00623	RNA modification / m6Am	EPIREG00018	EPITAR00067	.	Up regulation	m6A	Indirect	Enhancement	m6Am	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"VIRMA interacts with pri-miR-143, decreasing its m6A level and promoting its physical interaction with Signal transducer and activator of transcription 3 (STAT3), which was regulated by FTO-mediated m6Am modification. "	.	24410832; 34076564; 34537236; 34490238; 33190168	.
M6ACROT00571	REG00005	M6ATAR00623	RNA modification / m6Am	EPIREG00018	EPITAR00067	.	Down regulation	m6A	Indirect	Inhibition	m6Am	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"ALKBH5 interacts with pri-miR-143, decreasing its m6A level and inhibiting its physical interaction with Signal transducer and activator of transcription 3 (STAT3), which was regulated by FTO-mediated m6Am modification. "	.	24410832; 34076564; 34537236; 34490238; 33190168	.
M6ACROT00572	REG00007	M6ATAR00623	RNA modification / m5C	EPIREG00004	EPITAR00148	.	Down regulation	m6A	Indirect	Inhibition	m5C	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"METTL3 interacts with pri-miR-143, reading its m6A level and inhibiting its physical interaction with Hypoxia-inducible factor 1-alpha (HIF-1-Alpha/HIF1A), which was regulated by YBX1-mediated m5C modification. "	.	29029484; 31823788; 34428587; 33565800	.
M6ACROT00573	REG00015	M6ATAR00623	RNA modification / m5C	EPIREG00004	EPITAR00148	.	Up regulation	m6A	Indirect	Enhancement	m5C	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"VIRMA interacts with pri-miR-143, reading its m6A level and promoting its physical interaction with Hypoxia-inducible factor 1-alpha (HIF-1-Alpha/HIF1A), which was regulated by YBX1-mediated m5C modification. "	.	29029484; 34490238; 33565800	.
M6ACROT00574	REG00005	M6ATAR00623	RNA modification / m5C	EPIREG00004	EPITAR00148	.	Down regulation	m6A	Indirect	Inhibition	m5C	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"ALKBH5 interacts with pri-miR-143, reading its m6A level and inhibiting its physical interaction with Hypoxia-inducible factor 1-alpha (HIF-1-Alpha/HIF1A), which was regulated by YBX1-mediated m5C modification. "	.	29029484; 34490238; 33565800	.
M6ACROT00575	REG00007	M6ATAR00623	RNA modification / Pseudouridine	EPIREG00019	EPITAR00148	.	Down regulation	m6A	Indirect	Inhibition	Pseudouridine	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"METTL3 interacts with pri-miR-143, increasing its m6A level and inhibiting its physical interaction with Hypoxia-inducible factor 1-alpha (HIF-1-Alpha/HIF1A), which was regulated by DKC1-mediated Pseudouridine modification. "	.	31857720; 31823788; 34428587; 33565800	.
M6ACROT00576	REG00015	M6ATAR00623	RNA modification / Pseudouridine	EPIREG00019	EPITAR00148	.	Up regulation	m6A	Indirect	Enhancement	Pseudouridine	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"VIRMA interacts with pri-miR-143, increasing its m6A level and promoting its physical interaction with Hypoxia-inducible factor 1-alpha (HIF-1-Alpha/HIF1A), which was regulated by DKC1-mediated Pseudouridine modification. "	.	31857720; 34490238; 33565800	.
M6ACROT00577	REG00005	M6ATAR00623	RNA modification / Pseudouridine	EPIREG00019	EPITAR00148	.	Down regulation	m6A	Indirect	Inhibition	Pseudouridine	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"ALKBH5 interacts with pri-miR-143, increasing its m6A level and inhibiting its physical interaction with Hypoxia-inducible factor 1-alpha (HIF-1-Alpha/HIF1A), which was regulated by DKC1-mediated Pseudouridine modification. "	.	31857720; 34490238; 33565800	.
M6ACROT00578	REG00007	M6ATAR00623	RNA modification / m5C	EPIREG00001	EPITAR00147	.	Down regulation	m5C	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"NSUN2 interacts with H19 imprinted maternally expressed transcript (H19), increasing its m5C level and promoting its physical interaction with pri-miR-143, which was regulated by METTL3-mediated m6A modification."	.	32978516; 31823788; 34428587; 33758383	.
M6ACROT00579	REG00015	M6ATAR00623	RNA modification / m5C	EPIREG00001	EPITAR00147	.	Up regulation	m5C	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"NSUN2 interacts with H19 imprinted maternally expressed transcript (H19), increasing its m5C level and promoting its physical interaction with pri-miR-143, which was regulated by VIRMA-mediated m6A modification."	.	32978516; 34490238; 33758383	.
M6ACROT00580	REG00005	M6ATAR00623	RNA modification / m5C	EPIREG00001	EPITAR00147	.	Down regulation	m5C	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"NSUN2 interacts with H19 imprinted maternally expressed transcript (H19), increasing its m5C level and promoting its physical interaction with pri-miR-143, which was regulated by ALKBH5-mediated m6A modification."	.	32978516; 34490238; 33758383	.
M6ACROT00581	REG00004	M6ATAR00124	RNA modification / A-to-I	EPIREG00002	EPITAR00067	.	Up regulation	m6A	Indirect	Enhancement	A-to-I	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"HNRNPA2B1 interacts with microRNA 93 (MIR93), increasing its m6A level and promoting its physical interaction with Signal transducer and activator of transcription 3 (STAT3), which was regulated by ADAR1-mediated A-to-I modification. "	.	28278381; 34277606; 33900518	.
M6ACROT00582	REG00004	M6ATAR00124	RNA modification / m6Am	EPIREG00018	EPITAR00067	.	Up regulation	m6A	Indirect	Enhancement	m6Am	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"HNRNPA2B1 interacts with microRNA 93 (MIR93), decreasing its m6A level and promoting its physical interaction with Signal transducer and activator of transcription 3 (STAT3), which was regulated by FTO-mediated m6Am modification. "	.	24410832; 34076564; 34537236; 34277606; 33900518	.
M6ACROT00583	REG00004	M6ATAR00124	RNA modification / m5C	EPIREG00004	EPITAR00149	.	Up regulation	m6A	Indirect	Enhancement	m5C	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"HNRNPA2B1 interacts with microRNA 93 (MIR93), reading its m6A level and promoting its physical interaction with Ras GTPase-activating protein-binding protein 1 (G3BP1), which was regulated by YBX1-mediated m5C modification. "	.	31481087; 34277606; 33627622	.
M6ACROT00584	REG00007	M6ATAR00599	RNA modification / A-to-I	EPIREG00002	EPITAR00072	.	Up regulation	m6A	Indirect	Enhancement	A-to-I	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"METTL3 interacts with hsa-miR-193b, increasing its m6A level and promoting its physical interaction with G1/S-specific cyclin-D1 (CCND1), which was regulated by ADAR1-mediated A-to-I modification. "	.	28928239; 33750389; 34178650; 32580002	.
M6ACROT00585	REG00007	M6ATAR00599	RNA modification / m5C	EPIREG00004	EPITAR00072	.	Up regulation	m6A	Indirect	Enhancement	m5C	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"METTL3 interacts with hsa-miR-193b, reading its m6A level and promoting its physical interaction with G1/S-specific cyclin-D1 (CCND1), which was regulated by YBX1-mediated m5C modification. "	.	30426615; 32300640; 34082012; 34178650; 32580002	.
M6ACROT00586	REG00007	M6ATAR00599	RNA modification / m5C	EPIREG00020	EPITAR00072	.	Up regulation	m6A	Indirect	Enhancement	m5C	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"METTL3 interacts with hsa-miR-193b, decreasing its m6A level and promoting its physical interaction with G1/S-specific cyclin-D1 (CCND1), which was regulated by TET1-mediated m5C modification. "	.	32740973; 34178650; 32580002	.
M6ACROT00587	REG00007	M6ATAR00599	RNA modification / m6Am	EPIREG00018	EPITAR00072	.	Up regulation	m6A	Indirect	Enhancement	m6Am	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"METTL3 interacts with hsa-miR-193b, decreasing its m6A level and promoting its physical interaction with G1/S-specific cyclin-D1 (CCND1), which was regulated by FTO-mediated m6Am modification. "	.	32268083; 34178650; 32580002	.
M6ACROT00588	REG00007	M6ATAR00599	RNA modification / m7G	EPIREG00003	EPITAR00072	.	Up regulation	m6A	Indirect	Enhancement	m7G	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"METTL3 interacts with hsa-miR-193b, increasing its m6A level and promoting its physical interaction with G1/S-specific cyclin-D1 (CCND1), which was regulated by METTL1-mediated m7G modification. "	.	31866582; 34178650; 32580002	.
M6ACROT00589	REG00003	M6ATAR00132	RNA modification / A-to-I	EPIREG00002	EPITAR00078	.	Up regulation	m6A	Indirect	Enhancement	A-to-I	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"HNRNPC interacts with microRNA 21 (MIR21), increasing its m6A level and promoting its physical interaction with Protein sprouty homolog 2 (SPRY2), which was regulated by ADAR1-mediated A-to-I modification. "	.	29637273; 22907752; 34786052	.
M6ACROT00590	REG00007	M6ATAR00132	RNA modification / A-to-I	EPIREG00002	EPITAR00078	.	Up regulation	m6A	Indirect	Enhancement	A-to-I	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"METTL3 interacts with microRNA 21 (MIR21), increasing its m6A level and promoting its physical interaction with Protein sprouty homolog 2 (SPRY2), which was regulated by ADAR1-mediated A-to-I modification. "	.	29637273; 34164910; 34786052	.
M6ACROT00591	REG00003	M6ATAR00132	RNA modification / A-to-I	EPIREG00016	EPITAR00078	.	Up regulation	m6A	Indirect	Enhancement	A-to-I	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"HNRNPC interacts with microRNA 21 (MIR21), increasing its m6A level and promoting its physical interaction with Protein sprouty homolog 2 (SPRY2), which was regulated by ADARB1-mediated A-to-I modification. "	.	29637273; 22907752; 34786052	.
M6ACROT00592	REG00007	M6ATAR00132	RNA modification / A-to-I	EPIREG00016	EPITAR00078	.	Up regulation	m6A	Indirect	Enhancement	A-to-I	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"METTL3 interacts with microRNA 21 (MIR21), increasing its m6A level and promoting its physical interaction with Protein sprouty homolog 2 (SPRY2), which was regulated by ADARB1-mediated A-to-I modification. "	.	29637273; 34164910; 34786052	.
M6ACROT00593	REG00003	M6ATAR00132	RNA modification / m5C	EPIREG00004	EPITAR00145	.	Up regulation	m5C	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"YBX1 interacts with Growth arrest specific 5 (GAS5), reading its m5C sites and promoting its physical interaction with microRNA 21 (MIR21), which was regulated by HNRNPC-mediated m6A modification."	.	25959498; 31534503; 22907752; 31069831; 31572003; 31534503; 31319247	.
M6ACROT00594	REG00007	M6ATAR00132	RNA modification / m5C	EPIREG00004	EPITAR00145	.	Up regulation	m5C	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"YBX1 interacts with Growth arrest specific 5 (GAS5), reading its m5C sites and promoting its physical interaction with microRNA 21 (MIR21), which was regulated by METTL3-mediated m6A modification."	.	25959498; 31534503; 34164910; 31069831; 31572003; 31534503; 31319247	.
M6ACROT00595	REG00003	M6ATAR00132	RNA modification / m5C	EPIREG00021	EPITAR00150	.	Up regulation	m6A	Indirect	Enhancement	m5C	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"HNRNPC interacts with microRNA 21 (MIR21), increasing its m6A level and promoting its physical interaction with Phosphofructokinase, muscle (PFKM), which was regulated by NSUN7-mediated m5C modification. "	.	26774474; 22907752; 31914380	.
M6ACROT00596	REG00007	M6ATAR00132	RNA modification / m5C	EPIREG00021	EPITAR00150	.	Up regulation	m6A	Indirect	Enhancement	m5C	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"METTL3 interacts with microRNA 21 (MIR21), increasing its m6A level and promoting its physical interaction with Phosphofructokinase, muscle (PFKM), which was regulated by NSUN7-mediated m5C modification. "	.	26774474; 34164910; 31914380	.
M6ACROT00597	REG00003	M6ATAR00132	RNA modification / m5C	EPIREG00020	EPITAR00151	.	Up regulation	m6A	Indirect	Enhancement	m5C	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"HNRNPC interacts with microRNA 21 (MIR21), decreasing its m6A level and promoting its physical interaction with Mutated in multiple advanced cancers 1 (PTEN), which was regulated by TET1-mediated m5C modification. "	.	31656200; 22907752; 33332708; 33495842; 32412786; 31235554	.
M6ACROT00598	REG00007	M6ATAR00132	RNA modification / m5C	EPIREG00020	EPITAR00151	.	Up regulation	m6A	Indirect	Enhancement	m5C	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"METTL3 interacts with microRNA 21 (MIR21), decreasing its m6A level and promoting its physical interaction with Mutated in multiple advanced cancers 1 (PTEN), which was regulated by TET1-mediated m5C modification. "	.	31656200; 34164910; 33332708; 33495842; 32412786; 31235554	.
M6ACROT00599	REG00003	M6ATAR00132	RNA modification / m5C	EPIREG00022	EPITAR00151	.	Up regulation	m6A	Indirect	Enhancement	m5C	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"HNRNPC interacts with microRNA 21 (MIR21), decreasing its m6A level and promoting its physical interaction with Mutated in multiple advanced cancers 1 (PTEN), which was regulated by TET2-mediated m5C modification. "	.	31656200; 22907752; 33332708; 33495842; 32412786; 31235554	.
M6ACROT00600	REG00007	M6ATAR00132	RNA modification / m5C	EPIREG00022	EPITAR00151	.	Up regulation	m6A	Indirect	Enhancement	m5C	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"METTL3 interacts with microRNA 21 (MIR21), decreasing its m6A level and promoting its physical interaction with Mutated in multiple advanced cancers 1 (PTEN), which was regulated by TET2-mediated m5C modification. "	.	31656200; 34164910; 33332708; 33495842; 32412786; 31235554	.
M6ACROT00601	REG00003	M6ATAR00132	RNA modification / m5C	EPIREG00023	EPITAR00151	.	Up regulation	m6A	Indirect	Enhancement	m5C	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"HNRNPC interacts with microRNA 21 (MIR21), decreasing its m6A level and promoting its physical interaction with Mutated in multiple advanced cancers 1 (PTEN), which was regulated by TET3-mediated m5C modification. "	.	31656200; 22907752; 33332708; 33495842; 32412786; 31235554	.
M6ACROT00602	REG00007	M6ATAR00132	RNA modification / m5C	EPIREG00023	EPITAR00151	.	Up regulation	m6A	Indirect	Enhancement	m5C	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"METTL3 interacts with microRNA 21 (MIR21), decreasing its m6A level and promoting its physical interaction with Mutated in multiple advanced cancers 1 (PTEN), which was regulated by TET3-mediated m5C modification. "	.	31656200; 34164910; 33332708; 33495842; 32412786; 31235554	.
M6ACROT00603	REG00007	M6ATAR01230	RNA modification / A-to-I	EPIREG00002	EPITAR00102	.	Down regulation	m6A	Indirect	Inhibition	A-to-I	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"METTL3 interacts with hsa-mir-320a, increasing its m6A level and inhibiting its physical interaction with Catenin beta-1 (CTNNB1/Beta-catenin), which was regulated by ADAR1-mediated A-to-I modification. "	.	31572009; 31896070; 32778797	.
M6ACROT00604	REG00007	M6ATAR01230	RNA modification / m5C	EPIREG00004	EPITAR00102	.	Down regulation	m6A	Indirect	Inhibition	m5C	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"METTL3 interacts with hsa-mir-320a, reading its m6A level and inhibiting its physical interaction with Catenin beta-1 (CTNNB1/Beta-catenin), which was regulated by YBX1-mediated m5C modification. "	.	30905819; 31896070; 32778797	.
M6ACROT00605	REG00007	M6ATAR01230	RNA modification / m6Am	EPIREG00018	EPITAR00102	.	Down regulation	m6A	Indirect	Inhibition	m6Am	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"METTL3 interacts with hsa-mir-320a, decreasing its m6A level and inhibiting its physical interaction with Catenin beta-1 (CTNNB1/Beta-catenin), which was regulated by FTO-mediated m6Am modification. "	.	29315835; 34218271; 31896070; 32778797	.
M6ACROT00606	REG00007	M6ATAR01230	RNA modification / m5C	EPIREG00004	EPITAR00152	.	Down regulation	m6A	Indirect	Inhibition	m5C	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"METTL3 interacts with hsa-mir-320a, reading its m6A level and inhibiting its physical interaction with Homeobox protein NANOG (NANOG), which was regulated by YBX1-mediated m5C modification. "	.	28400280; 31896070; 31301305	.
M6ACROT00607	REG00007	M6ATAR01230	RNA modification / m6Am	EPIREG00018	EPITAR00152	.	Down regulation	m6A	Indirect	Inhibition	m6Am	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"METTL3 interacts with hsa-mir-320a, decreasing its m6A level and inhibiting its physical interaction with Homeobox protein NANOG (NANOG), which was regulated by FTO-mediated m6Am modification. "	.	33783988; 31896070; 31301305	.
M6ACROT00608	REG00007	M6ATAR01230	RNA modification / m7G	EPIREG00003	EPITAR00152	.	Down regulation	m6A	Indirect	Inhibition	m7G	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"METTL3 interacts with hsa-mir-320a, increasing its m6A level and inhibiting its physical interaction with Homeobox protein NANOG (NANOG), which was regulated by METTL1-mediated m7G modification. "	.	32698871; 31896070; 31301305	.
M6ACROT00609	REG00007	M6ATAR01230	RNA modification / m6Am	EPIREG00018	EPITAR00153	.	Down regulation	m6A	Indirect	Inhibition	m6Am	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"METTL3 interacts with hsa-mir-320a, decreasing its m6A level and inhibiting its physical interaction with Transcription factor E2F1 (E2F1), which was regulated by FTO-mediated m6Am modification. "	.	31827395; 31896070; 34659533	.
M6ACROT00610	REG00007	M6ATAR01230	RNA modification / m6Am	EPIREG00018	EPITAR00154	.	Down regulation	m6Am	Indirect	Inhibition	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"FTO interacts with Metastasis associated lung adenocarcinoma transcript 1 (MALAT1), decreasing it's m6Am level and inhibiting its physical interaction with hsa-mir-320a, which was regulated by METTL3-mediated m6A modification."	.	33634966; 34499008; 31896070; 31408432	.
M6ACROT00611	REG00006	M6ATAR00651	RNA modification / A-to-I	EPIREG00002	EPITAR00121	.	Up regulation	m6A	Indirect	Enhancement	A-to-I	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"METTL14 interacts with hsa-miR-34a, increasing its m6A level and promoting its physical interaction with G1/S-specific cyclin-E1 (CCNE1), which was regulated by ADAR1-mediated A-to-I modification. "	.	33750389; 33763423; 33033491	.
M6ACROT00612	REG00006	M6ATAR00651	RNA modification / m5C	EPIREG00004	EPITAR00121	.	Up regulation	m6A	Indirect	Enhancement	m5C	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"METTL14 interacts with hsa-miR-34a, reading its m6A level and promoting its physical interaction with G1/S-specific cyclin-E1 (CCNE1), which was regulated by YBX1-mediated m5C modification. "	.	30426615; 32300640; 33763423; 33033491	.
M6ACROT00613	REG00006	M6ATAR00651	RNA modification / m5C	EPIREG00020	EPITAR00121	.	Up regulation	m6A	Indirect	Enhancement	m5C	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"METTL14 interacts with hsa-miR-34a, decreasing its m6A level and promoting its physical interaction with G1/S-specific cyclin-E1 (CCNE1), which was regulated by TET1-mediated m5C modification. "	.	32740973; 33763423; 33033491	.
M6ACROT00614	REG00006	M6ATAR00651	RNA modification / A-to-I	EPIREG00002	EPITAR00123	.	Up regulation	A-to-I	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ADAR1 interacts with Nuclear paraspeckle assembly transcript 1 (NEAT1), increasing it's A-to-I level and promoting its physical interaction with hsa-miR-34a, which was regulated by METTL14-mediated m6A modification."	.	34302813; 33763423; 34468014	.
M6ACROT00615	REG00006	M6ATAR00651	RNA modification / m5C	EPIREG00004	EPITAR00155	.	Up regulation	m6A	Indirect	Enhancement	m5C	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"METTL14 interacts with hsa-miR-34a, reading its m6A level and promoting its physical interaction with Zinc finger protein SNAI1 (SNAI1), which was regulated by YBX1-mediated m5C modification. "	.	19411069; 24378923; 33763423; 34502497	.
M6ACROT00616	REG00006	M6ATAR00651	RNA modification / m5C	EPIREG00023	EPITAR00156	.	Up regulation	m6A	Indirect	Enhancement	m5C	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"METTL14 interacts with hsa-miR-34a, decreasing its m6A level and promoting its physical interaction with Apoptosis regulator Bcl-2 (BCL2), which was regulated by TET3-mediated m5C modification. "	.	25550811; 33763423; 31397599	.
M6ACROT00617	REG00006	M6ATAR00651	RNA modification / m5C	EPIREG00004	EPITAR00156	.	Up regulation	m6A	Indirect	Enhancement	m5C	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"METTL14 interacts with hsa-miR-34a, reading its m6A level and promoting its physical interaction with Apoptosis regulator Bcl-2 (BCL2), which was regulated by YBX1-mediated m5C modification. "	.	33763698; 33763423; 31397599	.
M6ACROT00618	REG00006	M6ATAR00651	RNA modification / m6Am	EPIREG00018	EPITAR00156	.	Up regulation	m6A	Indirect	Enhancement	m6Am	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"METTL14 interacts with hsa-miR-34a, decreasing its m6A level and promoting its physical interaction with Apoptosis regulator Bcl-2 (BCL2), which was regulated by FTO-mediated m6Am modification. "	.	30297871; 32825930; 33533172; 33763423; 31397599	.
M6ACROT00619	REG00006	M6ATAR00651	RNA modification / Pseudouridine	EPIREG00024	EPITAR00156	.	Up regulation	m6A	Indirect	Enhancement	Pseudouridine	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"METTL14 interacts with hsa-miR-34a, increasing its m6A level and promoting its physical interaction with Apoptosis regulator Bcl-2 (BCL2), which was regulated by PUS1-mediated Pseudouridine modification. "	.	31653659; 33763423; 31397599	.
M6ACROT00620	REG00006	M6ATAR00651	RNA modification / m5C	EPIREG00017	EPITAR00157	.	Up regulation	m6A	Indirect	Enhancement	m5C	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"METTL14 interacts with hsa-miR-34a, reading its m6A level and promoting its physical interaction with N-myc proto-oncogene protein (MYCN), which was regulated by ALYREF-mediated m5C modification. "	.	33767157; 33763423; 33330358	.
M6ACROT00621	REG00006	M6ATAR00651	RNA modification / m6Am	EPIREG00018	EPITAR00158	.	Up regulation	m6A	Indirect	Enhancement	m6Am	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"METTL14 interacts with hsa-miR-34a, decreasing its m6A level and promoting its physical interaction with Cytochrome c, somatic (CYCS), which was regulated by FTO-mediated m6Am modification. "	.	30648791; 33763423; 32094435	.
M6ACROT00622	REG00006	M6ATAR00651	RNA modification / m6Am	EPIREG00018	EPITAR00159	.	Up regulation	m6A	Indirect	Enhancement	m6Am	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"METTL14 interacts with hsa-miR-34a, decreasing its m6A level and promoting its physical interaction with NAD-dependent protein deacetylase sirtuin-1 (SIRT1), which was regulated by FTO-mediated m6Am modification. "	.	32154934; 33763423; 32903604	.
M6ACROT00623	REG00006	M6ATAR00651	RNA modification / m6Am	EPIREG00018	EPITAR00160	.	Up regulation	m6A	Indirect	Enhancement	m6Am	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"METTL14 interacts with hsa-miR-34a, decreasing its m6A level and promoting its physical interaction with Autophagy protein 5 (ATG5), which was regulated by FTO-mediated m6Am modification. "	.	32825930; 33763423; 30716314	.
M6ACROT00624	REG00006	M6ATAR00137	RNA modification / A-to-I	EPIREG00002	EPITAR00123	.	Up regulation	A-to-I	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ADAR1 interacts with Nuclear paraspeckle assembly transcript 1 (NEAT1), increasing it's A-to-I level and promoting its physical interaction with microRNA 126 (MIR126), which was regulated by METTL14-mediated m6A modification."	.	34302813; 27774652; 33677813	.
M6ACROT00625	REG00006	M6ATAR00137	RNA modification / m1A	EPIREG00009	EPITAR00161	.	Up regulation	m6A	Indirect	Enhancement	m1A	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"METTL14 interacts with microRNA 126 (MIR126), decreasing its m6A level and promoting its physical interaction with Vascular endothelial growth factor A (VEGFA), which was regulated by ALKBH3-mediated m1A modification. "	.	22826605; 22850567; 27774652; 34256796	.
M6ACROT00626	REG00006	M6ATAR00137	RNA modification / m7G	EPIREG00003	EPITAR00161	.	Up regulation	m6A	Indirect	Enhancement	m7G	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"METTL14 interacts with microRNA 126 (MIR126), increasing its m6A level and promoting its physical interaction with Vascular endothelial growth factor A (VEGFA), which was regulated by METTL1-mediated m7G modification. "	.	34136476; 27774652; 34256796	.
M6ACROT00627	REG00006	M6ATAR00137	RNA modification / m6Am	EPIREG00018	EPITAR00162	.	Up regulation	m6A	Indirect	Enhancement	m6Am	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"METTL14 interacts with microRNA 126 (MIR126), decreasing its m6A level and promoting its physical interaction with C-X-C chemokine receptor type 4 (CXCR4), which was regulated by FTO-mediated m6Am modification. "	.	31239444; 27774652; 31517442	.
M6ACROT00628	REG00006	M6ATAR01544	RNA modification / A-to-I	EPIREG00002	EPITAR00123	.	Up regulation	A-to-I	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"ADAR1 interacts with Nuclear paraspeckle assembly transcript 1 (NEAT1), increasing it's A-to-I level and promoting its physical interaction with hsa-mir-146a, which was regulated by METTL14-mediated m6A modification."	.	34302813; 32323801; 34584188	.
M6ACROT00629	REG00006	M6ATAR01544	RNA modification / m5C	EPIREG00004	EPITAR00145	.	Up regulation	m5C	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"YBX1 interacts with Growth arrest specific 5 (GAS5), reading its m5C sites and promoting its physical interaction with hsa-mir-146a, which was regulated by METTL14-mediated m6A modification."	.	25959498; 31534503; 32323801; 34329870	.
M6ACROT00630	REG00006	M6ATAR01544	RNA modification / m5C	EPIREG00017	EPITAR00163	.	Up regulation	m6A	Indirect	Enhancement	m5C	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"METTL14 interacts with hsa-mir-146a, reading its m6A level and promoting its physical interaction with Breast cancer type 1 susceptibility protein (BRCA1), which was regulated by ALYREF-mediated m5C modification. "	.	32989256; 32323801; 33030583	.
M6ACROT00631	REG00006	M6ATAR01544	RNA modification / m6Am	EPIREG00018	EPITAR00162	.	Up regulation	m6A	Indirect	Enhancement	m6Am	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"METTL14 interacts with hsa-mir-146a, decreasing its m6A level and promoting its physical interaction with C-X-C chemokine receptor type 4 (CXCR4), which was regulated by FTO-mediated m6Am modification. "	.	31239444; 32323801; 33382018	.
M6ACROT00632	REG00006	M6ATAR01544	RNA modification / m6Am	EPIREG00018	EPITAR00154	.	Up regulation	m6Am	Indirect	Inhibition	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"FTO interacts with Metastasis associated lung adenocarcinoma transcript 1 (MALAT1), decreasing it's m6Am level and inhibiting its physical interaction with hsa-mir-146a, which was regulated by METTL14-mediated m6A modification."	.	33634966; 34499008; 32323801; 32435156; 31291804; 33030583; 33382018	.
M6ACROT00633	REG00001	M6ATAR01150	RNA modification / A-to-I	EPIREG00025	EPITAR00164	.	Up regulation	m6A	Indirect	Enhancement	A-to-I	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"FTO interacts with hsa-mir-22, increasing its m6A level and promoting its physical interaction with NACHT, LRR and PYD domains-containing protein 3 (NLRP3), which was regulated by ADARB2-mediated A-to-I modification. "	.	34419568; 25723394; 34296520	.
M6ACROT00634	REG00001	M6ATAR01150	RNA modification / m5C	EPIREG00004	EPITAR00155	.	Up regulation	m6A	Indirect	Enhancement	m5C	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"FTO interacts with hsa-mir-22, reading its m6A level and promoting its physical interaction with Zinc finger protein SNAI1 (SNAI1), which was regulated by YBX1-mediated m5C modification. "	.	19411069; 24378923; 25723394; 31081061	.
M6ACROT00635	REG00001	M6ATAR01150	RNA modification / m5C	EPIREG00001	EPITAR00147	.	Up regulation	m5C	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"NSUN2 interacts with H19 imprinted maternally expressed transcript (H19), increasing its m5C level and promoting its physical interaction with hsa-mir-22, which was regulated by FTO-mediated m6A modification."	.	32978516; 25723394; 31081061	.
M6ACROT00636	REG00007	M6ATAR00129	RNA modification / m1A	EPIREG00009	EPITAR00165	.	Up regulation	m6A	Indirect	Enhancement	m1A	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"METTL3 interacts with microRNA 222 (MIR222), decreasing its m6A level and promoting its physical interaction with Cyclin-dependent kinase inhibitor 1B (CDKN1B/p27), which was regulated by ALKBH3-mediated m1A modification. "	.	21285982; 25799998; 31228940; 30718101	.
M6ACROT00637	REG00007	M6ATAR00129	RNA modification / m5C	EPIREG00001	EPITAR00165	.	Up regulation	m6A	Indirect	Enhancement	m5C	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"METTL3 interacts with microRNA 222 (MIR222), increasing its m6A level and promoting its physical interaction with Cyclin-dependent kinase inhibitor 1B (CDKN1B/p27), which was regulated by NSUN2-mediated m5C modification. "	.	26687548; 25799998; 31228940; 30718101	.
M6ACROT00638	REG00007	M6ATAR00129	RNA modification / m7G	EPIREG00003	EPITAR00165	.	Up regulation	m6A	Indirect	Enhancement	m7G	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"METTL3 interacts with microRNA 222 (MIR222), increasing its m6A level and promoting its physical interaction with Cyclin-dependent kinase inhibitor 1B (CDKN1B/p27), which was regulated by METTL1-mediated m7G modification. "	.	31866582; 25799998; 31228940; 30718101	.
M6ACROT00639	REG00007	M6ATAR00127	RNA modification / m5C	EPIREG00004	EPITAR00155	.	Up regulation	m6A	Indirect	Enhancement	m5C	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"METTL3 interacts with microRNA 25 (MIR25), reading its m6A level and promoting its physical interaction with Zinc finger protein SNAI1 (SNAI1), which was regulated by YBX1-mediated m5C modification. "	.	19411069; 24378923; 25799998; 32365051; 34396430	.
M6ACROT00640	REG00007	M6ATAR01292	RNA modification / m5C	EPIREG00004	EPITAR00145	.	Up regulation	m5C	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"YBX1 interacts with Growth arrest specific 5 (GAS5), reading its m5C sites and promoting its physical interaction with hsa-mir-18a, which was regulated by METTL3-mediated m6A modification."	.	25959498; 31534503; 33037176; 32538667; 34698360	.
M6ACROT00641	REG00004	M6ATAR01292	RNA modification / m5C	EPIREG00004	EPITAR00145	.	Up regulation	m5C	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"YBX1 interacts with Growth arrest specific 5 (GAS5), reading its m5C sites and promoting its physical interaction with hsa-mir-18a, which was regulated by HNRNPA2B1-mediated m6A modification."	.	25959498; 31534503; 34277606; 32538667; 34698360	.
M6ACROT00642	REG00007	M6ATAR01292	RNA modification / m5C	EPIREG00020	EPITAR00151	.	Up regulation	m6A	Indirect	Enhancement	m5C	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"METTL3 interacts with hsa-mir-18a, decreasing its m6A level and promoting its physical interaction with Mutated in multiple advanced cancers 1 (PTEN), which was regulated by TET1-mediated m5C modification. "	.	31656200; 33037176; 34194502	.
M6ACROT00643	REG00004	M6ATAR01292	RNA modification / m5C	EPIREG00020	EPITAR00151	.	Up regulation	m6A	Indirect	Enhancement	m5C	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"HNRNPA2B1 interacts with hsa-mir-18a, decreasing its m6A level and promoting its physical interaction with Mutated in multiple advanced cancers 1 (PTEN), which was regulated by TET1-mediated m5C modification. "	.	31656200; 34277606; 34194502	.
M6ACROT00644	REG00007	M6ATAR01292	RNA modification / m5C	EPIREG00022	EPITAR00151	.	Up regulation	m6A	Indirect	Enhancement	m5C	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"METTL3 interacts with hsa-mir-18a, decreasing its m6A level and promoting its physical interaction with Mutated in multiple advanced cancers 1 (PTEN), which was regulated by TET2-mediated m5C modification. "	.	31656200; 33037176; 34194502	.
M6ACROT00645	REG00004	M6ATAR01292	RNA modification / m5C	EPIREG00022	EPITAR00151	.	Up regulation	m6A	Indirect	Enhancement	m5C	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"HNRNPA2B1 interacts with hsa-mir-18a, decreasing its m6A level and promoting its physical interaction with Mutated in multiple advanced cancers 1 (PTEN), which was regulated by TET2-mediated m5C modification. "	.	31656200; 34277606; 34194502	.
M6ACROT00646	REG00007	M6ATAR01292	RNA modification / m5C	EPIREG00023	EPITAR00151	.	Up regulation	m6A	Indirect	Enhancement	m5C	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"METTL3 interacts with hsa-mir-18a, decreasing its m6A level and promoting its physical interaction with Mutated in multiple advanced cancers 1 (PTEN), which was regulated by TET3-mediated m5C modification. "	.	31656200; 33037176; 34194502	.
M6ACROT00647	REG00004	M6ATAR01292	RNA modification / m5C	EPIREG00023	EPITAR00151	.	Up regulation	m6A	Indirect	Enhancement	m5C	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"HNRNPA2B1 interacts with hsa-mir-18a, decreasing its m6A level and promoting its physical interaction with Mutated in multiple advanced cancers 1 (PTEN), which was regulated by TET3-mediated m5C modification. "	.	31656200; 34277606; 34194502	.
M6ACROT00648	REG00007	M6ATAR00130	RNA modification / m5C	EPIREG00004	EPITAR00145	.	Up regulation	m5C	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"YBX1 interacts with Growth arrest specific 5 (GAS5), reading its m5C sites and promoting its physical interaction with microRNA 221 (MIR221), which was regulated by METTL3-mediated m6A modification."	.	25959498; 31534503; 31228940; 33420414; 31631065; 31878844	.
M6ACROT00649	REG00007	M6ATAR00130	RNA modification / m6Am	EPIREG00018	EPITAR00159	.	Up regulation	m6A	Indirect	Enhancement	m6Am	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"METTL3 interacts with microRNA 221 (MIR221), decreasing its m6A level and promoting its physical interaction with NAD-dependent protein deacetylase sirtuin-1 (SIRT1), which was regulated by FTO-mediated m6Am modification. "	.	32154934; 31228940; 33420414; 32698791; 31631065; 34541816; 30926320	.
M6ACROT00650	REG00007	M6ATAR00130	RNA modification / m6Am	EPIREG00018	EPITAR00166	.	Up regulation	m6A	Indirect	Enhancement	m6Am	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"METTL3 interacts with microRNA 221 (MIR221), decreasing its m6A level and promoting its physical interaction with Protein c-Fos (FOS), which was regulated by FTO-mediated m6Am modification. "	.	34315853; 31228940; 33420414; 31081202	.
M6ACROT00651	REG00004	M6ATAR01248	RNA modification / m5C	EPIREG00004	EPITAR00145	.	Up regulation	m5C	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"YBX1 interacts with Growth arrest specific 5 (GAS5), reading its m5C sites and promoting its physical interaction with hsa-mir-106b, which was regulated by HNRNPA2B1-mediated m6A modification."	.	25959498; 31534503; 32246902; 34277606; 32991951	.
M6ACROT00652	REG00004	M6ATAR01248	RNA modification / m5C	EPIREG00020	EPITAR00151	.	Up regulation	m6A	Indirect	Enhancement	m5C	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"HNRNPA2B1 interacts with hsa-mir-106b, decreasing its m6A level and promoting its physical interaction with Mutated in multiple advanced cancers 1 (PTEN), which was regulated by TET1-mediated m5C modification. "	.	31656200; 32246902; 34277606; 32991951	.
M6ACROT00653	REG00004	M6ATAR01248	RNA modification / m5C	EPIREG00022	EPITAR00151	.	Up regulation	m6A	Indirect	Enhancement	m5C	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"HNRNPA2B1 interacts with hsa-mir-106b, decreasing its m6A level and promoting its physical interaction with Mutated in multiple advanced cancers 1 (PTEN), which was regulated by TET2-mediated m5C modification. "	.	31656200; 32246902; 34277606; 32991951	.
M6ACROT00654	REG00004	M6ATAR01248	RNA modification / m5C	EPIREG00023	EPITAR00151	.	Up regulation	m6A	Indirect	Enhancement	m5C	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"HNRNPA2B1 interacts with hsa-mir-106b, decreasing its m6A level and promoting its physical interaction with Mutated in multiple advanced cancers 1 (PTEN), which was regulated by TET3-mediated m5C modification. "	.	31656200; 32246902; 34277606; 32991951	.
M6ACROT00655	REG00001	M6ATAR00115	RNA modification / m5C	EPIREG00004	EPITAR00148	.	Up regulation	m6A	Indirect	Enhancement	m5C	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"FTO interacts with microRNA 576 (MIR576), reading its m6A level and promoting its physical interaction with Hypoxia-inducible factor 1-alpha (HIF-1-Alpha/HIF1A), which was regulated by YBX1-mediated m5C modification. "	.	29029484; 34725345; 31017266	.
M6ACROT00656	REG00001	M6ATAR00115	RNA modification / Pseudouridine	EPIREG00019	EPITAR00148	.	Up regulation	m6A	Indirect	Enhancement	Pseudouridine	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"FTO interacts with microRNA 576 (MIR576), increasing its m6A level and promoting its physical interaction with Hypoxia-inducible factor 1-alpha (HIF-1-Alpha/HIF1A), which was regulated by DKC1-mediated Pseudouridine modification. "	.	31857720; 34725345; 31017266	.
M6ACROT00657	REG00006	M6ATAR00118	RNA modification / m5C	EPIREG00004	EPITAR00148	.	Up regulation	m6A	Indirect	Enhancement	m5C	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"METTL14 interacts with microRNA 375 (MIR375), reading its m6A level and promoting its physical interaction with Hypoxia-inducible factor 1-alpha (HIF-1-Alpha/HIF1A), which was regulated by YBX1-mediated m5C modification. "	.	29029484; 31839484; 32215815	.
M6ACROT00658	REG00006	M6ATAR00118	RNA modification / Pseudouridine	EPIREG00019	EPITAR00148	.	Up regulation	m6A	Indirect	Enhancement	Pseudouridine	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"METTL14 interacts with microRNA 375 (MIR375), increasing its m6A level and promoting its physical interaction with Hypoxia-inducible factor 1-alpha (HIF-1-Alpha/HIF1A), which was regulated by DKC1-mediated Pseudouridine modification. "	.	31857720; 31839484; 32215815	.
M6ACROT00659	REG00006	M6ATAR00118	RNA modification / m5C	EPIREG00004	EPITAR00167	.	Up regulation	m6A	Indirect	Enhancement	m5C	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"METTL14 interacts with microRNA 375 (MIR375), reading its m6A level and promoting its physical interaction with Transcriptional coactivator YAP1 (YAP1), which was regulated by YBX1-mediated m5C modification. "	.	33951538; 31839484; 32626943	.
M6ACROT00660	REG00006	M6ATAR00118	RNA modification / m6Am	EPIREG00018	EPITAR00159	.	Up regulation	m6A	Indirect	Enhancement	m6Am	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"METTL14 interacts with microRNA 375 (MIR375), decreasing its m6A level and promoting its physical interaction with NAD-dependent protein deacetylase sirtuin-1 (SIRT1), which was regulated by FTO-mediated m6Am modification. "	.	32154934; 31839484; 33819576	.
M6ACROT00661	REG00006	M6ATAR00118	RNA modification / m6Am	EPIREG00018	EPITAR00154	.	Up regulation	m6Am	Indirect	Inhibition	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"FTO interacts with Metastasis associated lung adenocarcinoma transcript 1 (MALAT1), decreasing it's m6Am level and inhibiting its physical interaction with microRNA 375 (MIR375), which was regulated by METTL14-mediated m6A modification."	.	33634966; 34499008; 31839484; 32626943	.
M6ACROT00662	REG00006	M6ATAR00118	RNA modification / m7G	EPIREG00003	EPITAR00168	.	Up regulation	m6A	Indirect	Enhancement	m7G	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"METTL14 interacts with microRNA 375 (MIR375), increasing its m6A level and promoting its physical interaction with High mobility group protein HMGI-C (HMGA2), which was regulated by METTL1-mediated m7G modification. "	.	31031083; 31839484; 33433801	.
M6ACROT00663	REG00007	M6ATAR00109	RNA modification / m5C	EPIREG00004	EPITAR00169	.	Up regulation	m6A	Indirect	Enhancement	m5C	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"METTL3 interacts with microRNA 1246 (MIR1246), reading its m6A level and promoting its physical interaction with Glycogen synthase kinase-3 beta (GSK3Beta/GSK3B), which was regulated by YBX1-mediated m5C modification. "	.	32300640; 31492150; 33898106; 30913872	.
M6ACROT00664	REG00007	M6ATAR00109	RNA modification / m7G	EPIREG00026	EPITAR00170	.	Up regulation	m6A	Indirect	Enhancement	m7G	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"METTL3 interacts with microRNA 1246 (MIR1246), increasing its m6A level and promoting its physical interaction with Interleukin 6 (IL6), which was regulated by WDR4-mediated m7G modification. "	.	31289202; 31492150; 33898106; 31433911	.
M6ACROT00665	REG00007	M6ATAR01293	RNA modification / m5C	EPIREG00004	EPITAR00171	.	Up regulation	m6A	Indirect	Enhancement	m5C	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"METTL3 interacts with hsa-mir-20a, reading its m6A level and promoting its physical interaction with Ribonucleotide reductase regulatory subunit M2 (RRM2), which was regulated by YBX1-mediated m5C modification. "	.	32587247; 33037176; 34666602; 33125611	.
M6ACROT00666	REG00004	M6ATAR01293	RNA modification / m5C	EPIREG00004	EPITAR00171	.	Up regulation	m6A	Indirect	Enhancement	m5C	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"HNRNPA2B1 interacts with hsa-mir-20a, reading its m6A level and promoting its physical interaction with Ribonucleotide reductase regulatory subunit M2 (RRM2), which was regulated by YBX1-mediated m5C modification. "	.	32587247; 34277606; 33125611	.
M6ACROT00667	REG00007	M6ATAR01293	RNA modification / m5C	EPIREG00004	EPITAR00172	.	Up regulation	m6A	Indirect	Enhancement	m5C	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"METTL3 interacts with hsa-mir-20a, reading its m6A level and promoting its physical interaction with 72 kDa type IV collagenase (MMP2), which was regulated by YBX1-mediated m5C modification. "	.	34082012; 33037176; 34666602; 33788053	.
M6ACROT00668	REG00004	M6ATAR01293	RNA modification / m5C	EPIREG00004	EPITAR00172	.	Up regulation	m6A	Indirect	Enhancement	m5C	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"HNRNPA2B1 interacts with hsa-mir-20a, reading its m6A level and promoting its physical interaction with 72 kDa type IV collagenase (MMP2), which was regulated by YBX1-mediated m5C modification. "	.	34082012; 34277606; 33788053	.
M6ACROT00669	REG00007	M6ATAR01293	RNA modification / Pseudouridine	EPIREG00019	EPITAR00172	.	Up regulation	m6A	Indirect	Enhancement	Pseudouridine	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"METTL3 interacts with hsa-mir-20a, increasing its m6A level and promoting its physical interaction with 72 kDa type IV collagenase (MMP2), which was regulated by DKC1-mediated Pseudouridine modification. "	.	29901172; 30847721; 33037176; 34666602; 33788053	.
M6ACROT00670	REG00004	M6ATAR01293	RNA modification / Pseudouridine	EPIREG00019	EPITAR00172	.	Up regulation	m6A	Indirect	Enhancement	Pseudouridine	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"HNRNPA2B1 interacts with hsa-mir-20a, increasing its m6A level and promoting its physical interaction with 72 kDa type IV collagenase (MMP2), which was regulated by DKC1-mediated Pseudouridine modification. "	.	29901172; 30847721; 34277606; 33788053	.
M6ACROT00671	REG00007	M6ATAR01293	RNA modification / m6Am	EPIREG00018	EPITAR00154	.	Up regulation	m6Am	Indirect	Inhibition	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"FTO interacts with Metastasis associated lung adenocarcinoma transcript 1 (MALAT1), decreasing it's m6Am level and inhibiting its physical interaction with hsa-mir-20a, which was regulated by METTL3-mediated m6A modification."	.	33634966; 34499008; 33037176; 34666602; 31552681	.
M6ACROT00672	REG00004	M6ATAR01293	RNA modification / m6Am	EPIREG00018	EPITAR00154	.	Up regulation	m6Am	Indirect	Inhibition	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"FTO interacts with Metastasis associated lung adenocarcinoma transcript 1 (MALAT1), decreasing it's m6Am level and inhibiting its physical interaction with hsa-mir-20a, which was regulated by HNRNPA2B1-mediated m6A modification."	.	33634966; 34499008; 34277606; 31552681	.
M6ACROT00673	REG00006	M6ATAR01555	RNA modification / m5C	EPIREG00001	EPITAR00147	.	Up regulation	m5C	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"NSUN2 interacts with H19 imprinted maternally expressed transcript (H19), increasing its m5C level and promoting its physical interaction with hsa-mir-19a, which was regulated by METTL14-mediated m6A modification."	.	32978516; 32633395; 31170091	.
M6ACROT00674	REG00007	M6ATAR01555	RNA modification / m5C	EPIREG00001	EPITAR00147	.	Up regulation	m5C	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"NSUN2 interacts with H19 imprinted maternally expressed transcript (H19), increasing its m5C level and promoting its physical interaction with hsa-mir-19a, which was regulated by METTL3-mediated m6A modification."	.	32978516; 33037176; 31170091	.
M6ACROT00675	REG00007	M6ATAR01556	RNA modification / m5C	EPIREG00001	EPITAR00147	.	Up regulation	m5C	Indirect	Enhancement	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"NSUN2 interacts with H19 imprinted maternally expressed transcript (H19), increasing its m5C level and promoting its physical interaction with hsa-mir-19b-1, which was regulated by METTL3-mediated m6A modification."	.	32978516; 33037176; 33022863; 32738709; 34045678; 33053114	.
M6ACROT00676	REG00007	M6ATAR01556	RNA modification / m6Am	EPIREG00018	EPITAR00159	.	Up regulation	m6A	Indirect	Enhancement	m6Am	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"METTL3 interacts with hsa-mir-19b-1, decreasing its m6A level and promoting its physical interaction with NAD-dependent protein deacetylase sirtuin-1 (SIRT1), which was regulated by FTO-mediated m6Am modification. "	.	32154934; 33037176; 33022863	.
M6ACROT00677	REG00004	M6ATAR01252	RNA modification / m6Am	EPIREG00018	EPITAR00154	.	Up regulation	m6Am	Indirect	Inhibition	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"FTO interacts with Metastasis associated lung adenocarcinoma transcript 1 (MALAT1), decreasing it's m6Am level and inhibiting its physical interaction with hsa-mir-425, which was regulated by HNRNPA2B1-mediated m6A modification."	.	33634966; 34499008; 32246902; 31871512	.
M6ACROT00678	REG00005	M6ATAR00030	RNA modification / m6Am	EPIREG00018	EPITAR00154	.	Down regulation	m6Am	Indirect	Inhibition	m6A	RNA modification indirectly impacts m6A modification through downstream signaling pathways	"FTO interacts with Metastasis associated lung adenocarcinoma transcript 1 (MALAT1), decreasing it's m6Am level and inhibiting its physical interaction with hsa-mir-181b-1, which was regulated by ALKBH5-mediated m6A modification."	.	33634966; 34499008; 33431791; 31949884	.
M6ACROT00679	REG00007	M6ATAR01072	RNA modification / m6Am	EPIREG00018	EPITAR00173	.	Up regulation	m6A	Indirect	Enhancement	m6Am	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"METTL3 interacts with microRNA-92a, decreasing its m6A level and promoting its physical interaction with Krueppel-like factor 4 (KLF4), which was regulated by FTO-mediated m6Am modification. "	.	33783988; 33037176; 32432743; 34750028	.
M6ACROT00680	REG00007	M6ATAR01072	RNA modification / m6Am	EPIREG00018	EPITAR00174	.	Up regulation	m6A	Indirect	Enhancement	m6Am	m6A modification indirectly impacts RNA modification through downstream signaling pathways	"METTL3 interacts with microRNA-92a, decreasing its m6A level and promoting its physical interaction with Integrin alpha-6 (ITGA6), which was regulated by FTO-mediated m6Am modification. "	.	34499008; 33037176; 35168644	.